Neurodegeneration: Potential Causes, Prevention, and Future Treatment Options [PDF]
, 2011 Here I advance a hypothesis that neurodegeneration is a natural process associated with aging due to the loss of genetic redundancy following a mathematical model R(t) = R0(1-αe(βC+γI+δEt)t), where the calorie intake (C) and ...
Zhongtao Zhang
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Assembly, trafficking and function of gamma-secretase [PDF]
, 2006 gamma-Secretase catalyzes the final cleavage of the beta-amyloid precursor protein to generate amyloid-beta peptide, the principal component of amyloid plaques in the brains of patients suffering from Alzheimer's disease.
Baumeister R +9 more
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Epigenetic modifications of DNA and RNA in Alzheimer’s disease
Frontiers in Molecular NeuroscienceAlzheimer’s disease (AD) is a complex neurodegenerative disorder and the most common form of dementia. There are two main types of AD: familial and sporadic. Familial AD is linked to mutations in amyloid precursor protein (APP), presenilin-1 (PSEN1), and
Paula Martinez-Feduchi +2 more
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Human fibroblast and stem cell resource from the Dominantly Inherited Alzheimer Network
Alzheimer’s Research & Therapy, 2018 Background Mutations in amyloid precursor protein (APP), presenilin 1 (PSEN1) and presenilin 2 (PSEN2) cause autosomal dominant forms of Alzheimer disease (ADAD). More than 280 pathogenic mutations have been reported in APP, PSEN1, and PSEN2.
Celeste M. Karch +19 more
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The clinical utility of gene testing for Alzheimer’s disease
Neurology International, 2011 Alzheimer’s disease (AD) is the largest cause of dementia, affecting 35.6 million people in 2010. Amyloid precursor protein, presenilin 1 and presenilin 2 mutations are known to cause familial early-onset AD, whereas apolipoprotein E (APOE) ε4 is a ...
Emily R. Atkins, Peter K. Panegyres
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microRNA-183–5p induces cell density-dependent apoptosis through the regulation of Presenilin 2
European Journal of Cell BiologyCells undergo apoptosis under dense culture condition to maintain homeostasis. Impaired apoptosis may contribute to the excessive accumulation of pathogenetic cells in such diseases as cancer and organ fibrosis.
Yuki Yabuuchi +11 more
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Frontiers in Neurology, 2015 Our understanding of the pathogenesis of Alzheimer disease (AD) has been greatly influenced by investigation of rare families with autosomal dominant mutations that cause early onset AD. Mutations in the genes coding for Amyloid Precursor Protein (APP),
Suzanne Elizabeth Schindler +1 more
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Destruxin E Decreases Beta-Amyloid Generation by Reducing Colocalization of Beta-Amyloid-Cleaving Enzyme 1 and Beta-Amyloid Protein Precursor [PDF]
, 2009 Alzheimer-disease-associated beta-amyloid (A beta) is produced by sequential endoproteolysis of beta-amyloid protein precursor (beta APP): the extracellular portion is shed by cleavage in the juxtamembrane region by beta-amyloid-cleaving enzyme (BACE ...
Dohi, Keiji +27 more
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Discovery and validation of autosomal dominant Alzheimer’s disease mutations
Alzheimer’s Research & Therapy, 2018 Background Alzheimer’s disease (AD) is a neurodegenerative disease that is clinically characterized by progressive cognitive decline. Mutations in amyloid-β precursor protein (APP), presenilin 1 (PSEN1), and presenilin 2 (PSEN2) are the pathogenic cause ...
Simon Hsu +18 more
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Presenilin 2 N141I Mutation Induces Hyperimmunity by Immune Cell-specific Suppression of REV-ERBα without Altering Central Circadian Rhythm. [PDF]
Exp Neurobiol, 2023 Nam H, Kim B, Lee Y, Choe HK, Yu SW.
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