Results 131 to 140 of about 38,121 (213)
Mutant Presenilin 2 Transgenic Mice
Journal of Biological Chemistry, 2000 Naoya Sawamura +13 more
openaire +1 more source
A Physiological Role for Amyloid Beta Protein: Enhancement of Learning and Memory [PDF]
, 2008 Amyloid beta protein (A[beta]) is well recognized as having a significant role in the pathogenesis of Alzheimer's disease (AD). The reason for the presence of A[beta] and its physiological role in non-disease states is not clear.
John Morley +5 more
core +1 more source
Differential expression and modulation of presenilin-1 and presenilin-2 in neural cell lines
ABSTRACTPresenilin proteins, the catalytic components of the γ-secretase enzyme, play a key role in the pathogenesis of Alzheimer’s disease primarily by generating amyloid-β peptides. Although often grouped together, Presenilin-1 (PS1) and Presenilin-2 (PS2) are distinct proteins that contribute differently to γ-secretase activity.
Melissa K. Eccles +5 more
openaire +1 more source
New mechanism of metformin action mediated by lysosomal presenilin enhancer 2
Journal of Diabetes Investigation, 2023 Kenji Sugawara, Wataru Ogawa
doaj +1 more source
Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer's disease. [PDF]
, 2019 Apolipoprotein (apo) E4 is the major genetic risk factor for Alzheimer's disease (AD), increasing risk and decreasing age of disease onset. Many studies have demonstrated the detrimental effects of apoE4 in varying cellular contexts.
Huang, Yadong +2 more
core +1 more source
Intracellular Calcium Dysregulation by the Alzheimer's Disease-Linked Protein Presenilin 2. [PDF]
Int J Mol Sci, 2020 Galla L +4 more
europepmc +1 more source
Pleiotropic effects of variants in dementia genes in Parkinson disease [PDF]
, 2018 Benitez, Bruno A +11 more
core +2 more sources
Early-onset familial Alzheimer's disease in a family with mutation of presenilin 2 gene. [PDF]
Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2021 Li C, Xiao X, Wang J, Shen L, Jiao B.
europepmc +1 more source
Down syndrome and a presenilin 2 variant: dual genetic risk of Alzheimer's disease. [PDF]
Acta NeuropatholOgg J +9 more
europepmc +1 more source