Loss of normal Alzheimer's disease-associated Presenilin 2 function alters antiseizure medicine potency and tolerability in the 6-Hz focal seizure model. [PDF]
Front Neurol, 2023 Lehmann LM, Barker-Haliski M.
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Neural Regeneration ResearchA reduction in adult neurogenesis is associated with behavioral abnormalities in patients with Alzheimer’s disease. Consequently, enhancing adult neurogenesis represents a promising therapeutic approach for mitigating disease symptoms and progression ...
Biao Xiao +8 more
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Transmembrane BAX inhibitor motif containing 6 suppresses presenilin-2 to preserve mitochondrial integrity after myocardial ischemia-reperfusion injury. [PDF]
Int J Biol Sci, 2023 Ma L +8 more
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Interaction of Alzheimer's Presenilin-1 and Presenilin-2 with Bcl-XL [PDF]
Journal of Biological Chemistry, 1999 Brent J. Passer +4 more
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Structural Predictive Model of Presenilin-2 Protein and Analysis of Structural Effects of Familial Alzheimer's Disease Mutations. [PDF]
Biochem Res Int, 2021 Soto-Ospina A +3 more
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Investigating the Interactions Between Protocadherin-19 and Ryk and its Effect on Neurogenesis [PDF]
, 2016 Protocadherins are a large, diverse family of neural cell adhesion proteins, but their functions are not understood. Mutations or in several protocadherins have been associated with neurological disorders.
Liebau, Brandon
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In-Frame and Frameshift Mutations in Zebrafish Presenilin 2 Affect Different Cellular Functions in Young Adult Brains. [PDF]
J Alzheimers Dis Rep, 2021 Barthelson K +4 more
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Early Diagnosis of Alzheimer's disease by NIRF Spectroscopy and Nuclear Medicine-v.4.0 [PDF]
, 2011 There is an urgent need for the early detection of diseases such as Alzheimer’s (AD) and Cancers in order to enable their successful treatment. Cancer is the second major cause of death after Heart Disease, and AD is the third major cause of death
I Baianu
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Age-related increase of oxidative stress-induced apoptosis in mice prevention by Ginkgo biloba extract (EGb761) [PDF]
, 2006 Enhanced apoptosis and elevated levels of reactive oxygen species (ROS) play a major role in aging. In addition, several neurodegenerative diseases are associated with increased oxidative stress and apoptosis in neuronal tissue.
Eckert, Anne +4 more
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Studies on the association between Alzheimer's disease and vascular risk factors: reports from China
Chinese Journal of Contemporary Neurology and Neurosurgery, 2015 Alzheimer's disease (AD) is the most common cause of dementia, accounting for 60% to 80% of all types of dementia. Both genetic and non-genetic factors may take part in the etiopathogenesis of AD.
Ya LI +5 more
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