Results 161 to 170 of about 38,121 (213)

Functional Characterization of a Signal Peptide Peptidase in <i>Phaffia rhodozyma</i> Reveals a Potential Role in Protein Stress Response but Not in Activation of the SREBP Ortholog Sre1. [PDF]

Int J Mol Sci
Baeza M, Gómez M, Apariz G, Barahona S, Alcaíno J.   +4 more
europepmc   +1 more source

Correction to: Comorbidities in early-onset sporadic versus presenilin-1 mutation-associated Alzheimer disease dementia: Evidence for dependency on Alzheimer disease neuropathological changes. [PDF]

J Neuropathol Exp Neurol
europepmc   +1 more source

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Mutation of conserved aspartates affect maturation of presenilin 1 and presenilin 2 complexes.

Acta neurologica Scandinavica. Supplementum, 2001
Presenilin (PS1 and PS2) holoproteins are transiently incorporated into low molecular weight (MW) complexes. During subsequent incorporation into a higher MW complex, they undergo endoproteolysis to generate stable N- and C-terminal fragments (NTF/CTF).
Tandon, A, Holmes, E, Rogaeva, E, Arawaka, S, Supala, A, St GeorgeHyslop, P, Haass, C, Fraser, P, Milman, P, Zhang, DM, Kawarai, T, Chen, F, Yu, G, Steiner, H, Nishimura, M, Song, YQ   +15 more
openaire   +4 more sources

Abstract 14800: Presenilin 1 and Presenilin 2 Contribute to Mitophagy Including Alternative Pathway

Circulation, 2020
Introduction: Presenilin 1 (PS1) and presenilin 2 (PS2) are proteins that compose γ-secretase, which is a protease present in late endosome lysosomes. Recently, amyloid beta accumulation was found in the cardiomyocytes of Alzheimer's disease patients and cause cardiac dysfunction. Mutations in PSEN1 and
Tsunenori Saito, Roberta A Gottlieb
openaire   +1 more source

Biochemical properties of endogenous presenilin 1 and presenilin 2 in cultured human B-lymphocytes

Clinical Chemical Laboratory Medicine, 2007
AbstractClin Chem Lab Med 2007;45:1273–6.
Lukasz, Bojarski, Andrzej, Lewandowicz, Magdalena, Blazejczyk, Adam, Sobczak, Jacek, Kuznicki, Urszula, Wojda   +5 more
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Presenilin 2 — APP Interactions

1998
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder of the central nervous system which is invariably associated with and defined by the presence of intracellular neurofibrillary tangles (NFT) and extracellular deposits of amyloid (Aβ senile plaques) in the brain and cerebral blood vessels.
W. Wasco, R. E. Tanzi, R. D. Moir, A. C. Crowley, D. E. Merriam, D. M. Romano, P. D. Jondro, B. A. Kellerman   +7 more
openaire   +1 more source