Results 171 to 180 of about 38,121 (213)
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Increased Expression of Presenilin 2 Inhibits Protein Synthesis
Molecular and Cellular Neuroscience, 2002Mutations in the presenilin genes PS1 and PS2 are a major cause of early onset familial Alzheimer's disease (AD). Previous studies have suggested that presenilins have several functions, including gamma-secretase activity. It was also shown that presenilin expression is increased in the brains of some AD patients and ischemic rodents. The present study
Amir, Gamliel +6 more
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Presenilin and Amyloidogenesis: A Structure-Function Relationship Study on Presenilin 2
2002Alzheimer’s disease (AD) is a progressive dementing neurodegenerative disorder characterized pathologically by the presence of senile plaques and neurofibrillary changes in the brains of affected individuals (1). Senile plaques are composed of amyloid β peptides (An) comprised of —40 amino acids that are proteolytically produced from ββ-amyloid ...
Takeshi Iwatsubo +5 more
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Cloning of the cDNA encoding rat presenilin-2
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1998We report here the cDNA sequence of rat homologue of presenilin-2 (PS-2). The rat PS-2 cDNA encoded 448 amino acids, and the deduced amino acid sequence was highly homologous to those of the human (94.9%), mouse (96.4%) and Xenopus (70.8%). A minor splicing variant lacking a single glutamate was detected, while the product corresponding to the exon 9 ...
H, Tanahashi, T, Tabira
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Journal of Neuroscience Research, 1999
Because distinct mutations in presenilin 1 and presenilin 2 are a major cause of early-onset familial Alzheimer's disease, we generated four monoclonal antibodies for the identification, localization, and investigation of presenilins in various cell lines and tissues from patients and controls.
A, Diehlmann +7 more
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Because distinct mutations in presenilin 1 and presenilin 2 are a major cause of early-onset familial Alzheimer's disease, we generated four monoclonal antibodies for the identification, localization, and investigation of presenilins in various cell lines and tissues from patients and controls.
A, Diehlmann +7 more
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Atypical dementia associated with a novel presenilin‐2 mutation
Annals of Neurology, 2003Abstract We describe an Italian pedigree with hereditary dementia associated with a novel T122R mutation in the presenilin‐2 gene (PSEN2) . The clinical history, symptom presentation, and structural neuroimaging were consistent with an atypical form of dementia.
BINETTI G +16 more
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Polymorphisms in the presenilin 1 and presenilin 2 genes and risk for sporadic Alzheimer’s disease
Journal of the Neurological Sciences, 1999We examined the possible involvement of polymorphisms of the presenilin 1 (PS1) and presenilin 2 (PS2) genes in the risk for sporadic Alzheimer's disease (AD), either through an independent effect or through interaction with the existing apolipoprotein E (ApoE) risk, in 211 AD cases and 188 age-matched control subjects.
O, Combarros +9 more
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A Review of the Familial Alzheimer’s Disease Locus PRESENILIN 2 and Its Relationship to PRESENILIN 1
Journal of Alzheimer's Disease, 2018PRESENILIN 1 (PSEN1) and PRESENILIN 2 (PSEN2) genes are loci for mutations causing familial Alzheimer’s disease (fAD). However, the function of these genes and how they contribute to fAD pathogenesis has not been fully determined. This review provides a summary of the overlapping and independent functions of the PRESENILINS with a focus on the lesser ...
Haowei, Jiang +3 more
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Molecular and Cellular Biochemistry, 2010
We used forebrain-specific conditional presenilin 1 (PS1) and presenilin 2 (PS2) double knockout mice (dKO mice), which exhibit neurodegenerative disease-like symptoms, including inflammation of the brain and periphery, to investigate whether periodontal and salivary tissues display alterations.
Wenfei, Han +7 more
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We used forebrain-specific conditional presenilin 1 (PS1) and presenilin 2 (PS2) double knockout mice (dKO mice), which exhibit neurodegenerative disease-like symptoms, including inflammation of the brain and periphery, to investigate whether periodontal and salivary tissues display alterations.
Wenfei, Han +7 more
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Structure and alternative splicing of the Presenilin-2 gene
NeuroReport, 1996Missense mutations in the presenilin-1 (PS-1) and presenilin-2 (PS-2) genes have been shown to be causes of autosomal dominant Alzheimer's disease (the AD3 and AD4 loci, respectively). Alternative splicing has previously been reported in the PS-1 gene.
G, Prihar +17 more
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Mutant presenilin 2 increases acetylcholinesterase activity in neuronal cells
Archives of Pharmacal Research, 2005A presenilin 2 mutation is believed to be involved in the development of Alzheimer's disease. In addition, transgenic mice with a presenilin 2 mutation have been reported to have learning and memory impairments. In this study, exposing PC12 cells expressing mutant presenilin 2 to 50 microM AP25-35, 30 mM L-glutamate and 50 microM H2O2 caused a ...
Hong Nga, Nguyen +9 more
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