Results 181 to 190 of about 38,121 (213)

Calorie restriction ameliorates neurodegenerative phenotypes in forebrain-specific presenilin-1 and presenilin-2 double knockout mice

Neurobiology of Aging, 2008
Conditional double knockout of presenilin-1 and presenilin-2 (cDKO) in forebrain of mice led to brain atrophy, tau hyperphosphorylation, synaptic dysfunction and cognitive deficit. These brain changes recapitulated most of the neurodegenerative phenotypes of Alzheimer's disease (AD).
Pu, Wu, Qian, Shen, Suzhen, Dong, Zhiliang, Xu, Joe Z, Tsien, Yinghe, Hu   +5 more
openaire   +2 more sources

Cloning and characterization of the presenilin-2 gene promoter

Molecular Brain Research, 1998
Mutations in the presenilin-2 (PS-2) have been shown to cause early onset Alzheimer's disease (AD) in a series of families known as the Volga Germans and in an unrelated Italian kindred. Expression of the PS-2 gene is regulated during AD, aging, development and brain injury.
K R, Pennypacker, R, Fuldner, R, Xu, H, Hernandez, D, Dawbarn, N, Mehta, J, Perez-Tur, M, Baker, M, Hutton   +8 more
openaire   +2 more sources

Monogenic determinants of familial Alzheimer's disease: presenilin-2 mutations

Cellular and Molecular Life Sciences CMLS, 1998
Presenilin-2 (PS2) is one of three genes [amyloid precursor protein (APP), presenilin-1 (PS1) and PS2] shown to cause familial Alzheimer's disease (FAD), and is highly homologous to PS1. Currently demonstrated functions of PS2 include interactions with APP and A beta, and participation in apoptotic pathways.
P, Renbaum, E, Levy-Lahad
openaire   +2 more sources

Subcellular localization of presenilin 2 endoproteolytic C-terminal fragments

Molecular Brain Research, 2001
Mutations in the genes that encode the presenilin 1 and 2 (PS1 and PS2) proteins cause the majority of familial Alzheimer's disease (FAD). Differential cleavage of the presenilins results in a generation of at least two C-terminal fragments (CTFs).
T L, Tekirian, D E, Merriam, V, Marshansky, J, Miller, A C, Crowley, H, Chan, D, Ausiello, D, Brown, J D, Buxbaum, W, Xia, W, Wasco   +10 more
openaire   +2 more sources

The Circadian Regulation ofPresenilin‐2Gene Expression

Chronobiology International, 2006
Circadian rhythms are generated by a molecular clock composed of clock genes and their protein products. Other genes are regulated in a rhythmic way by this molecular clockwork, but are not themselves constituents of the clock. This study shows that one of these clock-controlled genes encodes the signalling protein Presenilin-2.
Valérie, Bélanger, Nathalie, Picard, Nicolas, Cermakian   +2 more
openaire   +2 more sources

58 Presenilin 1 and presenilin 2 in the mouse and rat brain

Neurobiology of Aging, 1996
S. Moussaoui, C. Czech, L. Pradier, B. Bonici, V. Blanchard, M. Gohin, A. Triller, F. Revah, A. Imperato   +8 more
openaire   +1 more source

Role of presenilin 1 and presenilin 2 in APP and Notch processing

Neurobiology of Aging, 2000
Bart De Strooper, Wim Annaert
openaire   +1 more source

Presenilin-2

2013
openaire   +1 more source

The role of presenilin cofactors in the γ-secretase complex

Nature, 2003
Nobumasa Takasugi, Taisuke Tomita, Gopal Thinakaran   +2 more
exaly  

Destabilization of β-catenin by mutations in presenilin-1 potentiates neuronal apoptosis

Nature, 1998
Zhuohua Zhang, Hans Clevers, Paul Saftig
exaly