Results 181 to 190 of about 2,165,687 (231)

Early Diagnostic Measures to Confirm the Diagnosis of Human Prion Diseases. [PDF]

Cureus, 2023
Desai N, Purzycki T.
europepmc   +1 more source

Combating ageing beyond the cell: Emerging roles of extracellular proteostasis

The FEBS Journal, Volume 293, Issue 18, Page 5558-5584, September 2026.
Ageing challenges the body's ability to maintain a stable and functional proteome, leading to protein damage and aggregation both inside and outside cells. This review focuses on the less well understood mechanisms of extracellular protein quality control and how they become disrupted in ageing, particularly in neurodegenerative diseases.
Siddharth R. Venkatesh, Ivan Gallotta, Bolanle F. Olabiyi, Yoon Hee Choi, Sarah Inglesfield, Janet R. Kumita, Collin Y. Ewald, Della C. David   +7 more
wiley   +1 more source

D178N prion protein mutation endows RML prions with new strain properties that do not mimic human genetic prion diseases. [PDF]

Acta Neuropathol
Masone A, Grasso A, Comerio L, Bruno R, Lavigna G, Vanni I, D'Agostino C, Orrù CD, Caughey B, Altmeppen HC, Castilla J, Giaccone G, Tagliavini F, Di Bari MA, Nonno R, Chiesa R.   +15 more
europepmc   +1 more source

“S‐Tau‐Lled” Lysosomes Disrupt Autophagic Processes in Neurodegeneration

Traffic, Volume 27, Issue 3, September 2026.
Tauopathies are neurodegenerative diseases characterized by misfolded tau accumulation and lysosomal dysfunction. Pathogenic mutant Tau stalls lysosomes in iPSC‐derived neurons upstream of Tau accumulation. Pharmacological activation of autophagy activation reduces Tau burden without rescuing lysosome motility, revealing that trafficking and ...
Anaïs Bécot, Mehdi Kabani
wiley   +1 more source

Prion diseases: Lessons from historical outbreaks and potential emerging ones. [PDF]

Protein Sci
Holman AP, Kurouski D.
europepmc   +1 more source

Safety of Acheta domesticus (house cricket) spray‐dried powder as a Novel food pursuant to Regulation (EU) 2015/2283

EFSA Journal, Volume 24, Issue 9, September 2026.
Abstract Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on the safety of a spray‐dried powder from house cricket (Acheta domesticus) as a novel food (NF) pursuant to Regulation (EU) 2015/2283.
EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Dominique Turck, Torsten Bohn, Montaña Cámara, Jacqueline Castenmiller, Stefaan De Henauw, Ángeles Jos, Alexandre Maciuk, Inge Mangelsdorf, Breige McNulty, Androniki Naska, Kristina Pentieva, Alfonso Siani, Frank Thies, Margarita Aguilera‐Gómez, Thomas Frenzel, Harry J. McArdle, Peter Moldeus, Monika Neuhäuser‐Berthold, Josef Rudolf Schlatter, Henk van Loveren, Areti Favata, Fernando Rivero‐Pino, Ermolaos Ververis, Karen Ildico Hirsch‐Ernst   +25 more
wiley   +1 more source

Therapeutic perspectives for prion diseases in humans and animals. [PDF]

PLoS Pathog
Benavente R, Morales R.
europepmc   +1 more source

Development of a user guide to support administration of the MRC Prion Disease Rating Scale in research and clinical settings for prion diseases. [PDF]

Prion
Pulido RS, Marshall C, Smith AV, Edge H, Yarlas A, Appleby B, Brandel JP, Collins S, Omer N, Zerr I, Mead S.   +10 more
europepmc   +1 more source

1-L Transcription in Prion Diseases. [PDF]

Int J Mol Sci
Nahalka J.
europepmc   +1 more source

Exploring immunotherapeutic strategies for neurodegenerative diseases: a focus on Huntington's disease and Prion diseases. [PDF]

Acta Pharmacol Sin
Mukherjee A, Biswas S, Roy I.
europepmc   +1 more source