Results 91 to 100 of about 16,662 (259)

Recent US Case of Variant Creutzfeldt-Jakob Disease—Global Implications

Emerging Infectious Diseases, 2015
Variant Creutzfeldt-Jakob disease (vCJD) is a rare, fatal prion disease resulting from transmission to humans of the infectious agent of bovine spongiform encephalopathy. We describe the clinical presentation of a recent case of vCJD in the United States
Atul Maheshwari, Michael Fischer, Pierluigi Gambetti, Alicia Parker, Aarthi Ram, Claudio Soto, Luis Concha-Marambio, Yvonne Cohen, Ermias D. Belay, Ryan A. Maddox, Simon Mead, Clay Goodman, Joseph S. Kass, Lawrence B. Schonberger, Haitham M. Hussein   +14 more
doaj   +1 more source

Molecular dynamics studies on the NMR and X-ray structures of rabbit prion protein wild-type and mutants

, 2013
Prion diseases are invariably fatal and highly infectious neurodegenerative diseases that affect a wide variety of mammalian species such as sheep, goats, mice, humans, chimpanzees, hamsters, cattle, elks, deer, minks, cats, chicken, pigs, turtles, etc ...
Barlow, Baron, Barry, Barry, Barry, Bastian, Bencsik, Bendheim, Bett, Biswas, Bitel, Bjorndahl, Bockman, Bode, Brun, Caughey, Chianini, Cho, Chou, Chou, Chou, Chou, Chou, Chou, Chou, Christen, Christen, Christen, Christen, Cong, Courageot, Damberger, Di Martino, Dong, Dupiereux, Farquhar, Fernandez-Funez, Fernandez-Funez, Fernandez-Funez, Fernández-Borges, Friedman-Levi, Gabizon, Gabizon, Gao, Garrec, Garssen, Gerber, Gilch, Golanska, Gossert, Groschup, Groschup, Groschup, Guiroy, Handisurya, Hanoux, Hashimoto, Hay, Huang, Ikegami, Ishiguro, Ishikawa, Jackman, Jiapu Zhang, Julien, Kabsch, Kascsak, Kascsak, Kelker, Khan, Kim, Kirby, Kirkwood, Kitamoto, Kocisko, Komar, Korth, Laude, Lawson, Li, Li, Loftus, Lopez, Lührs, Ma, Madec, Mays, Meli, Merz, Miller, Nisbet, Oboznaya, Onodera, Polymenidou, Pérez, Riek, Robakis, Roberts, Rossetti, Sachsamanoglou, Sakudo, Schmerr, Senator, Shin, Shinagawa, Sigurdson, Sigurdson, Sigurdson, Stanker, Sweeting, Takahashi, Takahashi, Takekida, Tang, Timmes, Vidal, Vilette, Vol'pina, Vorberg, Wade, Wang, Wen, Wen, Wiley, Xi, Xiao, Yokoyama, Yokoyama, Yost, Yuanli Zhang, Zahn, Zhang, Zhang, Zhang, Zhang, Zhang, Zhao, Zhou, Zhou, Zhou, Zhou, Zhou, Zocche Soprana   +142 more
core   +1 more source

The prion protein regulates glutamate-mediated Ca2+ entry and mitochondrial Ca2+ accumulation in neurons [PDF]

, 2017
The cellular prion protein (PrPC) whose conformational misfolding leads to the production of deadly prions, has a still-unclarified cellular function despite decades of intensive research.
Bertoli, Alessandro, Castellani, Angela, Giacomello, Marta, Lim, Dmitry, Mario, Agnese De, Massimino, Maria Lina, Peggion, Caterina, Sorgato, Maria Catia, Viviani, Francesca   +8 more
core   +1 more source

Association of recurrence patterns and outcome with HR and HER2 status in patients with resected brain metastases from breast cancer

International Journal of Cancer, EarlyView.
What's New? While treatment strategies for solid brain metastases have been relatively uniform across cancer subtypes, tailored approaches are warranted. In this observational study, intracranial recurrences after microsurgical resection occurred significantly earlier and more frequently at distant sites in patients with triple‐negative breast cancer ...
Jonathan Weller, Sophie Katzendobler, Frederic Thiele, Anna Riesberg, Patrick N. Harter, Frederick Klauschen, Rachel Wuerstlein, Stephan Schoenecker, Montserrat Pazos Escudero, Robert Forbrig, Niklas Thon, Florian Ringel, Michael Weller, Emilie Le Rhun, Veit M. Stoecklein   +14 more
wiley   +1 more source

Prion-induced neurotoxicity: Possible role for cell cycle activity and DNA damage response. [PDF]

, 2015
Protein misfolding neurodegenerative diseases arise through neurotoxicity induced by aggregation of host proteins. These conditions include Alzheimer's disease, Huntington's disease, Parkinson's disease, motor neuron disease, tauopathies and prion ...

core   +1 more source

Pyridoxal Reprograms Peroxisomal Hydrogen Peroxide Metabolism to Induce Lethal Oxidative Stress in Ovarian Cancer

iMetaMed, EarlyView.
Pyridoxal (PL) exhibits the strongest anti‐tumor activity within the vitamin B6 family, demonstrating significant ovarian cancer cell‐killing efficacy in vivo, in vitro, and in patient‐derived organoid (PDO) models. The anti‐tumor mechanism involves PL inducing a shift in peroxisome dynamics towards fission, promoting peroxisome proliferation, and ...
Ruonan Li, Huiyan Wang, Dunke Zhang, Qiuying Gu, Jinlong Wang, Bin Liu, Huabin Gao, Jingya Duan, Yimin Liu, Xiaolan Huang, Youquan Bu, Tongchuan He, Hua Linghu   +12 more
wiley   +1 more source

Mouse-adapted scrapie strains 139A and ME7 overcome species barrier to induce experimental scrapie in hamsters and changed their pathogenic features

Virology Journal, 2012
Background Transmissible spongiform encephalopathy (TSE) diseases are known to be zoonotic diseases that can infect different kinds of animals. The transmissibility of TSE, like that of other infectious diseases, shows marked species barrier, either ...
Shi Qi, Zhang Bao-Yun, Gao Chen, Zhang Jin, Jiang Hui-Ying, Chen Cao, Han Jun, Dong Xiao-Ping   +7 more
doaj   +1 more source

Endogenous Viral Etiology of Prion Diseases [PDF]

, 2009
Transmissible spongiform encephalopathies (TSEs), or prion diseases, are a group of incurable neurodegenerative disorders, including Kuru and Creutzfeldt-Jakob disease in humans, “mad cow” disease in cattle, and scrapie in sheep. This paper
Claudiu I. Bandea
core   +1 more source

The Spectrum of Abnormal Tongue Movements: Review of Phenomenology, Etiology, and Differential Diagnosis

Movement Disorders Clinical Practice, EarlyView.
ABSTRACT Background Classifying abnormal tongue movements is challenging due to their varied presentations and limited visibility compared to other body parts. Accurate identification of the phenomenology guides physical examination and can point to specific diagnoses.
Nathaniel Bendahan, Seyed‐Mohammad Fereshtehnejad, Christos Ganos, Emily Swinkin, Anthony E. Lang   +4 more
wiley   +1 more source

The frequency of yeast [PSI+] prion formation is increased during chronological ageing

Microbial Cell, 2017
Ageing involves a time-dependent decline in a variety of intracellular mechanisms and is associated with cellular senescence. This can be exacerbated by prion diseases which can occur in a sporadic manner, predominantly during the later stages of life ...
Shaun H. Speldewinde, Chris M. Grant
doaj   +1 more source