Results 41 to 50 of about 16,662 (259)

Chronic Wasting Disease Prions in Elk Antler Velvet

Emerging Infectious Diseases, 2009
Chronic wasting disease (CWD) is a contagious, fatal prion disease of deer and elk that continues to emerge in new locations. To explore the means by which prions are transmitted with high efficiency among cervids, we examined prion infectivity in the ...
Rachel C. Angers, Tanya S. Seward, Dana Napier, Michael Green, Edward Hoover, Terry Spraker, Katherine O’Rourke, Aru Balachandran, Glenn C. Telling   +8 more
doaj   +1 more source

Helices 2 and 3 are the initiation sites in the PrPc -> PrPsc transition

, 2012
It is established that prion protein is the sole causative agent in a number of diseases in humans and animals. However, the nature of conformational changes that the normal cellular form PrPC undergoes in the conversion process to a self-replicating ...
Chen, Jie, Thirumalai, Devarajan
core   +1 more source

Populations of Tau Conformers Drive Prion-like Strain Effects in Alzheimer’s Disease and Related Dementias

Cells, 2022
Recent findings of diverse populations of prion-like conformers of misfolded tau protein expand the prion concept to Alzheimer’s disease (AD) and monogenic frontotemporal lobar degeneration (FTLD)-MAPT P301L, and suggest that distinct strains of misfolded proteins drive the phenotypes and progression rates in many neurodegenerative diseases.
Lenka Hromadkova, Mohammad Khursheed Siddiqi, He Liu, Jiri G. Safar   +3 more
openaire   +3 more sources

A Case–Control Study on the Origin of Atypical Scrapie in Sheep, France

Emerging Infectious Diseases, 2009
A matched case–control study (95 cases and 220 controls) was designed to study risk factors for atypical scrapie in sheep in France. We analyzed contacts with animals from other flocks, lambing and feeding practices, and exposure to toxic substances ...
Alexandre Fediaevsky, Eric Morignat, Christian Ducrot, Didier Calavas   +3 more
doaj   +1 more source

Cellular Prion Protein Mediates Toxic Signaling of Amyloid Beta [PDF]

, 2011
Prion diseases in humans and animals comprise a group of invariably fatal neurodegenerative diseases characterized by the formation of a pathogenic protein conformer designated PrPSc and infectious particles denoted prions.
Resenberger, Ulrike K., Tatzelt, Jörg, Winklhofer, Konstanze F.   +2 more
core   +1 more source

Key points concerning amyloid infectivity and prion-like neuronal invasion

Frontiers in Molecular Neuroscience, 2016
Amyloid aggregation has been related to an increasing number of human illnesses, from Alzheimer and Parkinson’s diseases to Creutzfeldt-Jakob disease. Traditionally only prions have been considered as infectious agents with a high capacity of propagation.
Alba eEspargaró, Maria Antònia eBusquets, Joan eEstelrich, Raimon eSabate   +3 more
doaj   +1 more source

A Review on the Salt Bridge Between ASP177 and ARG163 of Wild-Type Rabbit Prion Protein

, 2015
Prion diseases are invariably fatal and highly infectious neurodegenerative diseases that affect a wide variety of mammalian species such as sheep and goats, cattle, deer, elks, humans and mice etc., but rabbits have a low susceptibility to be infected ...
Wang, Feng, Zhang, Jiapu
core   +2 more sources

Scrapie at Abattoir: Monitoring, Control, and Differential Diagnosis of Wasting Conditions during Meat Inspection

Animals, 2021
Wasting disease in small ruminants is frequently detected at slaughterhouses. The wasting disorder is manifested by the deterioration of the nutritional and physiological state of the animal indicated by thinness, emaciation, and cachexia.
Alexandra Esteves, Madalena Vieira-Pinto, Hélder Quintas, Leonor Orge, Adelina Gama, Anabela Alves, Fernanda Seixas, Isabel Pires, Maria de Lurdes Pinto, Ana Paula Mendonça, Carla Lima, Carla Neves Machado, João Carlos Silva, Paula Tavares, Filipe Silva, Estela Bastos, Jorge Pereira, Nuno Gonçalves-Anjo, Paulo Carvalho, Roberto Sargo, Ana Matos, Luís Figueira, Maria dos Anjos Pires   +22 more
doaj   +1 more source

Disease-related Prion Protein Forms Aggresomes in Neuronal Cells Leading to Caspase Activation and Apoptosis [PDF]

Journal of Biological Chemistry, 2005
The molecular basis for neuronal death in prion disease is not established, but putative pathogenic roles for both disease-related prion protein (PrP(Sc)) and accumulated cytosolic PrP(C) have been proposed. Here we report that only prion-infected neuronal cells become apoptotic after mild inhibition of the proteasome, and this is strictly dependent ...
Mark, Kristiansen, Marcus J, Messenger, Peter-Christian, Klöhn, Sebastian, Brandner, Jonathan D F, Wadsworth, John, Collinge, Sarah J, Tabrizi   +6 more
openaire   +2 more sources

Adult‐Onset Subacute Sclerosing Panencephalitis Presenting With Subacute Cognitive Deficits

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We describe the case of a 41‐year‐old man diagnosed with adult‐onset subacute sclerosing panencephalitis (SSPE). The patient presented with subacute progressive cognitive deficits and a neuropsychological profile indicating predominant frontoparietal dysfunction. MRI showed only mild parietal‐predominant cerebral atrophy.
Dennis Yeow, Nicola McKern, Vincent Oxenham, Kate Ahmad, Omar Ahmad   +4 more
wiley   +1 more source