Results 161 to 170 of about 2,435,950 (372)
Analysis of the parish register of baptisms of today’s parish Veljaci (1786-1808)
Geoadria, 2015 This study examines demographic trends within the micro unit Veljaci in the municipality of Ljubuški. The sources of primary data were the oldest registers of births from the turn of the 19th century in the area encompassed in the parish Veljaci.
Ivan Madžar, Vladimir Pavičić
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Probing the free energy landscapes of ALS disease mutants of SOD1 by NMR spectroscopy [PDF]
, 2016 Ashok Sekhar +6 more
openalex +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Clinical OphthalmologyJutaro Nakamura,1,2 Tomoko Ohno,2 Yuki Mizuki,1 Masaki Takeuchi,1 Nobuhisa Mizuki,1 Nozomi Matsumura1,2 1Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan; 2Department of ...
Nakamura J +5 more
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FEBS Open Bio, EarlyView.Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.Angubindin‐1 binds angulin‐1/‐3 at tricellular tight junctions, enhancing intestinal macromolecule permeation. Alanine scanning identified six essential residues (L562, L598, E638, V640, Y643, and K644) of angubindin‐1 critical for binding to angulin‐1/‐3 and permeation‐enhancing activity, providing insights for the development of targeted noninvasive ...
Taiki Kuzu +8 more
wiley +1 more source
FEBS Open Bio, EarlyView.Here, we introduced an intermittent electrical stimulation protocol mimicking the episodic nature of real‐life exercise in vitro by alternating low‐ and high‐frequency stimulation. In comparison with widely used continuous stimulation, it enhanced the rate of glucose and fatty acid oxidation, but not the myokine release.
Klára Gabrišová +11 more
wiley +1 more source
An Atom Probe Tomography study of site preference and partitioning in a nickel-based superalloy
, 2016 Paul A.J. Bagot +8 more
openalex +2 more sources