Results 91 to 100 of about 2,950 (183)
Microvascular Health as a Key Determinant of Organismal Aging
Advanced Science, Volume 12, Issue 47, December 18, 2025.Abstract Aging is a complex, multifaceted process affecting all organ systems, with vascular aging playing a central role in organismal health decline. Beyond its role in circulation, the vascular system acts as a dynamic interface between tissues, influencing countless physiological functions such as tissue regeneration and repair, immune responses ...
Mattia Cenciarini +4 more
wiley +1 more source
Expression of progerin does not result in an increased mutation rate [PDF]
, 2016 Abstract In the premature ageing disease Hutchinson-Gilford progeria syndrome (HGPS) the underlying genetic defect in the lamin A gene leads to accumulation at the nuclear lamina of progerin – a mutant form of lamin A that cannot be correctly processed.
Deniaud, Emmanuelle +2 more
openaire +1 more source
Increased progerin expression and TUNEL+ cells in DCM hearts.
, 2018 A Immunohistochemistry showing increased numbers of progerin expressing cells (arrows, red nuclei) in DCM hearts compared to non-failing controls. Scale bar represents 100μM (rows 1–2) and 25μM (rows 3–4).
Santhosh Kumar Ghadge (5150576) +6 more
core +1 more source
PLoS ONEHutchinson-Gilford Progeria Syndrome (HGPS) is a rare genetic condition characterized by features of accelerated aging, and individuals with HGPS seldom live beyond their mid-teens.
Liza A Joudeh +5 more
doaj +1 more source
Progerin forms an abnormal meshwork and has a dominant-negative effect on the nuclear lamina [PDF]
Progerin, the protein that causes Hutchinson-Gilford progeria syndrome, triggers nuclear membrane (NM) ruptures and blebs, but the mechanisms are unclear.
Jung, Hyesoo +8 more
core +1 more source
Cell Reports, 2018 Summary: Hutchinson-Gilford progeria syndrome (HGPS) is a premature aging disease caused by a truncated lamin A protein (progerin) that drives cellular and organismal decline.
Ray Kreienkamp +9 more
doaj +1 more source
Ignoring the planet: A critical blind spot for research on ageing
Journal of Internal Medicine, Volume 298, Issue 6, Page 578-590, December 2025.Abstract Although research on ageing has largely concentrated on understanding the fundamental biology of the ageing process and devising pharmaceutical interventions in order to slow it down, increasing evidence has underscored the crucial role of environmental inputs across the life course and across generations, in shaping both individual and ...
Paul Shiels +6 more
wiley +1 more source
Temsirolimus increases progerin clearance via autophagy.
, 2016 (A) Representative Western blot of control (GMO3349C) and HGPS (HGADFN 003, HGADFN127) fibroblasts that were either mock-treated or Temsirolimus-treated (Tem) for a period of 9 days.
Diana Gabriel (3608093) +2 more
core +1 more source
Decoding Dental Stem Cell Aging: Mechanisms, Therapeutic Strategies, and Beyond
Advanced Science, Volume 12, Issue 44, November 27, 2025.Dental stem cell (DSC) aging involves genomic instability, mitochondrial dysfunction, telomere attrition, and epigenetic alterations, leading to impaired proliferation, reduced differentiation potential, and pro‐inflammatory secretory activity. These processes drive cellular senescence and compromise regenerative and immunomodulatory functions, thereby
Xinyuan Zhao +7 more
wiley +1 more source
Nucleus, 2020 Hutchinson-Gilford progeria syndrome (HGPS) is a premature aging disorder caused by a mutation of lamin A, which contributes to nuclear architecture and the spatial organization of chromatin in the nucleus.
Yuto Takahashi +8 more
doaj +1 more source