Results 91 to 100 of about 2,732 (185)

Progerin expression disrupts critical adult stem cell functions involved in tissue repair [PDF]

, 2014
Vascular disease is one of the leading causes of death worldwide. Vascular repair, essential for tissue maintenance, is critically reduced during vascular disease and aging.
Gomez, Lourdes Adriana, Ziebarth, Noel M, Pacheco, Laurin Marie, Dias, Janice, Schiller, Paul C, Howard, Guy A   +5 more
core   +1 more source

Clinicopathological Challenge: A Progressively Enlarging Hardened Skin Plaque

International Journal of Dermatology, Volume 65, Issue 1, Page 15-17, January 2026.
ABSTRACT Stiff skin syndrome (SSS) is a rare connective tissue disease manifesting as a progressive, non‐inflammatory fibrosis that causes the skin and soft tissues to harden. It can result in restricted joint movement, particularly affecting the shoulder and pelvic girdle. A segmental variant with a better prognosis has been described.
Marian Fernández Martínez, Frida Paola Rivera Lira, Rodrigo Roldán‐Marín, Sonia Toussaint‐Caire   +3 more
wiley   +1 more source

Microvascular Health as a Key Determinant of Organismal Aging

Advanced Science, Volume 12, Issue 47, December 18, 2025.
Abstract Aging is a complex, multifaceted process affecting all organ systems, with vascular aging playing a central role in organismal health decline. Beyond its role in circulation, the vascular system acts as a dynamic interface between tissues, influencing countless physiological functions such as tissue regeneration and repair, immune responses ...
Mattia Cenciarini, Andrea Uccelli, Francesca Mangili, Myriam Grunewald, Simone Bersini   +4 more
wiley   +1 more source

Sulforaphane enhances progerin clearance in Hutchinson–Gilford progeria fibroblasts [PDF]

, 2015
Hutchinson–Gilford progeria syndrome (HGPS, OMIM 176670) is a rare multisystem childhood premature aging disorder linked to mutations in the LMNA gene. The most common HGPS mutation is found at position G608G within exon 11 of the LMNA gene.
Djabali, Karima, Roedl, Daniela, Gabriel, Diana, Gordon, Leslie   +3 more
core   +1 more source

Unique Preservation of Neural Cells in Hutchinson- Gilford Progeria Syndrome Is Due to the Expression of the Neural-Specific miR-9 MicroRNA

Cell Reports, 2012
One puzzling observation in patients affected with Hutchinson-Gilford progeria syndrome (HGPS), who overall exhibit systemic and dramatic premature aging, is the absence of any conspicuous cognitive impairment. Recent studies based on induced pluripotent
Xavier Nissan, Sophie Blondel, Claire Navarro, Yves Maury, Cécile Denis, Mathilde Girard, Cécile Martinat, Annachiara De Sandre-Giovannoli, Nicolas Levy, Marc Peschanski   +9 more
doaj   +1 more source

Potential Benefits of Allogeneic Haploidentical Adipose Tissue-Derived Stromal Vascular Fraction in a Hutchinson–Gilford Progeria Syndrome Patient

Frontiers in Bioengineering and Biotechnology, 2020
Hutchinson–Gilford progeria syndrome (HGPS) is a rare, fatal, and genetic disorder in the LMNA gene encoding for prelamin A. Normally, prelamin A is processed to become lamin A protein.
Jaewoo Pak, Jaewoo Pak, Jung Hun Lee, Jung Hun Lee, Jeong Ho Jeon, Young Bae Kim, Byeong Chul Jeong, Sang Hee Lee   +7 more
doaj   +1 more source

Progerin forms an abnormal meshwork and has a dominant-negative effect on the nuclear lamina [PDF]

Progerin, the protein that causes Hutchinson-Gilford progeria syndrome, triggers nuclear membrane (NM) ruptures and blebs, but the mechanisms are unclear.
Jung, Hyesoo, Tu, Yiping, Jeong, JY Brian, Kim, Joonyoung R, Fong, Loren G, Presnell, Ashley, Kim, Paul H, Tran, Anh P, Young, Stephen G   +8 more
core   +1 more source

RT-PCR reveals expression of progerin mRNA in DA. [PDF]

, 2013
A. RT-PCR analysis of LMNA and progerin mRNA in neonatal aorta and DA was performed with primers that amplify 270 and 185 bp of LMNA, and 120 bp of progerin. GUSB PCR product was used as a control.
Regina Bökenkamp (344823), Elizabeth G. Nabel (75420), Michelle Olive (344826), Vered Raz (197916), Marco C. DeRuiter (344824), Andrea Venema (197914), Conny van Munsteren (344825), Adriana C. Gittenberger-de Groot (344827)   +7 more
core   +1 more source

Ignoring the planet: A critical blind spot for research on ageing

Journal of Internal Medicine, Volume 298, Issue 6, Page 578-590, December 2025.
Abstract Although research on ageing has largely concentrated on understanding the fundamental biology of the ageing process and devising pharmaceutical interventions in order to slow it down, increasing evidence has underscored the crucial role of environmental inputs across the life course and across generations, in shaping both individual and ...
Paul Shiels, Ognian Neytchev, Gillian Borland, Polina Germushkina, Richard Johnson, Peter Stenvinkel, Tina Woods   +6 more
wiley   +1 more source

Progerin can induce DNA damage in the absence of global changes in replication or cell proliferation.

PLoS ONE
Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare genetic condition characterized by features of accelerated aging, and individuals with HGPS seldom live beyond their mid-teens.
Liza A Joudeh, P Logan Schuck, Nina M Van, Alannah J DiCintio, Jason A Stewart, Alan S Waldman   +5 more
doaj   +1 more source