Results 101 to 110 of about 3,871 (195)

Organ‐Specific Dedifferentiation and Epigenetic Remodeling in In Vivo Reprogramming

Aging Cell, Volume 24, Issue 11, November 2025.
Transient in vivo expression of Yamanaka factors (OSKM) enhances regenerative competence and rejuvenation across multiple tissues. We highlight mechanistic links between injury‐induced dedifferentiation and OSKM reprogramming, while emphasizing safety challenges and the need for precise spatiotemporal control to enable clinical translation.
Beom‐Ki Jo, Seung‐Yeon Lee, Hee‐Ji Eom, Jumee Kim, Hyuk‐Jin Cha   +4 more
wiley   +1 more source

Modeling Alzheimer's disease with human induced pluripotent stem (iPS) cells [PDF]

, 2016
In the last decade, induced pluripotent stem (iPS) cells have revolutionized the utility of human in vitro models of neurological disease. The iPS-derived and differentiated cells allow researchers to study the impact of a distinct cell type in health ...
Mungenast, Alison, Siegert, Sandra, Tsai, Li-Huei   +2 more
core   +2 more sources

Foetal disruptive brain injuries: Diagnosing the underlying pathogenetic mechanisms with cranial ultrasonography

Developmental Medicine &Child Neurology, Volume 67, Issue 11, Page 1383-1408, November 2025.
Plain language summary: https://onlinelibrary.wiley.com/doi/10.1111/dmcn.16431 Abstract Antenatal destructive events affecting the central nervous system of the foetus lead to disruptive brain lesions that are often associated with impaired neurodevelopment.
Ana Alarcón, Nuria Carreras, Tobias Muehlbacher, Dídac Casas‐Alba, Roberta Arena, Paola Roca‐Llabrés, Juan Navarro‐Morón, Linda S. de Vries, Paul Govaert, the EurUS.Brain group, Thais Agut, Roberta Arena, Ana Alarcón, Juan Arnáez, Marco Bartocci, Isabel Benavente‐Fernández, María Carmen Bravo, Fernando Cabañas, Nuria Carreras, Olivier Claris, Jeroen Dudink, Monica Fumagalli, Alfredo García‐Alix, Paul Govaert, Sandra Horsch, Simón Lubián, Tobias Muehlbacher, Alessandro Parodi, Adelina Pellicer, Luca Ramenghi, Charles C. Roehr, Simone Schwarz, Sylke Steggerda, Eva Valverde   +33 more
wiley   +1 more source

Investigating pediatric disorders with induced pluripotent stem cells [PDF]

, 2018
The study of disease pathophysiology has long relied on model systems, including animal models and cultured cells. In 2006, Shinya Yamanaka achieved a breakthrough by reprogramming somatic cells into induced pluripotent stem cells (iPSCs).
Cadar, Adrian G., Chun, Young W., Durbin, Matthew D., Hong, Charles C.   +3 more
core   +1 more source

Impairment of nuclear F-actin formation and its relevance to cellular phenotypes in Hutchinson-Gilford progeria syndrome

Nucleus, 2020
Hutchinson-Gilford progeria syndrome (HGPS) is a premature aging disorder caused by a mutation of lamin A, which contributes to nuclear architecture and the spatial organization of chromatin in the nucleus.
Yuto Takahashi, Shogo Hiratsuka, Nanako Machida, Daisuke Takahashi, Junpei Matsushita, Pavel Hozak, Tom Misteli, Kei Miyamoto, Masahiko Harata   +8 more
doaj   +1 more source

Unique Preservation of Neural Cells in Hutchinson- Gilford Progeria Syndrome Is Due to the Expression of the Neural-Specific miR-9 MicroRNA

Cell Reports, 2012
One puzzling observation in patients affected with Hutchinson-Gilford progeria syndrome (HGPS), who overall exhibit systemic and dramatic premature aging, is the absence of any conspicuous cognitive impairment. Recent studies based on induced pluripotent
Xavier Nissan, Sophie Blondel, Claire Navarro, Yves Maury, Cécile Denis, Mathilde Girard, Cécile Martinat, Annachiara De Sandre-Giovannoli, Nicolas Levy, Marc Peschanski   +9 more
doaj   +1 more source

From Genome to Geroscience: How DNA Damage Shapes Systemic Decline

BioEssays, Volume 47, Issue 10, October 2025.
Persistent DNA damage triggers systemic secretory responses including damage‐associated molecular patterns (DAMPs), the senescence‐associated secretory phenotype (SASP), and extracellular vesicles (EVs). This non‐cell‐autonomous signaling disrupts intercellular communication, driving organism‐wide dysfunction and aging, and offering new therapeutic ...
Athanasios Siametis, George A. Garinis
wiley   +1 more source

The role of Nrf2 signaling in counteracting neurodegenerative diseases [PDF]

, 2018
The transcription factor Nrf2 (nuclear factor-erythroid 2 p45-related factor 2) functions at the interface of cellular redox and intermediary metabolism.
Abeti, Acosta, Alarcon-Aguilar, Bartolome, Baxter, Bell, Bellaver, Bott, Calap-Quintana, Chen, Chowdhry, Clark, Corenblum, Csiszar, Csiszar, Cullinan, D'Oria, Dayalan Naidu, Dinkova-Kostova, Dinkova-Kostova, Dinkova-Kostova, Dinkova-Kostova, Dinkova-Kostova, East, Esteras, FangFang, Flowers, Fragoulis, Georgakopoulos, Giordano, Goode, Goode, Gotzl, Greco, Greco, Hardie, Hayes, Hensley, Hoenen, Holmstrom, Jang, Jarrott, Jazwa, Jimenez-Sanchez, Jin, Johnson, Joshi, Kandimalla, Kerr, Knatko, Kobayashi, Kobayashi, Komatsu, Kovacs, Kubben, Kumar, Kumar, Kwak, Kwon, Lastres-Becker, Lee, Liddell, Linker, Lipton, Liu, Lo, Ludtmann, Luis, Meng, Mitsuishi, Moinova, Morrison, Mota, Moujalled, Navarro, Neymotin, Olagnier, Pajares, Paupe, Piantadosi, Polymeropoulos, Prasad, Prasad, Quinti, Quinti, Rada, Rainero, Rojo, Rojo, Sabouny, Sahdeo, Serini, Shan, Sheng, Skibinski, Stack, Thimmulappa, Tian, Townsend, Tufi, Valente, Vargas, Vargas, Vargas, Wang, Wild, Williamson, Wu, Wu, Yamazaki, Yang, Zhang, Zhang   +112 more
core   +2 more sources

CURE ID: A Platform to Collect Real‐World Treatment Data for Drug Repurposing in Rare Genetic Disorders

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, Volume 199, Issue 3, Page 189-193, September 2025.
ABSTRACT Rare diseases collectively affect millions of Americans, but less than 5% have approved treatments, and new drug development remains limited. For such diseases, drug repurposing may be an effective strategy to find new treatment options. In the rare genetic disorder community, drugs are frequently prescribed off‐label.
Tahsin Farid, Maura R. Z. Ruzhnikov, Mili Duggal, Keyla C. Tumas, Shira Strongin, Eric Sid, Sarah R. Fuchs, Leonard Sacks, Dominique C. Pichard, Catherine Pilgrim‐Grayson, Ewy A. Mathé, Heather A. Stone   +11 more
wiley   +1 more source

Temsirolimus Partially Rescues the Hutchinson-Gilford Progeria Cellular Phenotype.

PLoS ONE, 2016
Hutchinson-Gilford syndrome (HGPS, OMIM 176670, a rare premature aging disorder that leads to death at an average age of 14.7 years due to myocardial infarction or stroke, is caused by mutations in the LMNA gene.
Diana Gabriel, Leslie B Gordon, Karima Djabali   +2 more
doaj   +1 more source