Results 111 to 120 of about 2,950 (183)

RT-PCR reveals expression of progerin mRNA in DA.

, 2013
A. RT-PCR analysis of LMNA and progerin mRNA in neonatal aorta and DA was performed with primers that amplify 270 and 185 bp of LMNA, and 120 bp of progerin. GUSB PCR product was used as a control.
Regina Bökenkamp (344823), Elizabeth G. Nabel (75420), Michelle Olive (344826), Vered Raz (197916), Marco C. DeRuiter (344824), Andrea Venema (197914), Conny van Munsteren (344825), Adriana C. Gittenberger-de Groot (344827)   +7 more
core   +1 more source

Atherosclerosis in progeria: insight from new mouse models with systemic and tissue-specific progerin expression [PDF]

, 2019
Tesis doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Medicina, Departamento de Bioquímica. Fecha de lectura: 19-09-2017Esta tesis tiene embargado el acceso al texto completo hasta el 19-03-2019Cardiovascular disease (CVD) is
Hamczyk, Magda Rita
core   +1 more source

The Anaphase Promoting Complex targets the toxic protein Progerin for ubiquitin-dependent degradation via autophagy

The premature aging disease Hutchinson-Gilford Progeria Syndrome (HGPS) results from the accumulation of progerin, a cytotoxic protein generated from a point mutation in the Lamin A/C gene, in the nuclear lamina.
Morgan Fleming, Christopher H Eskiw, Matthew Lubachowski, Troy A. A. Harkness, Zoe E. Gillespie, Valeria Martinez   +5 more
core   +1 more source

Progerin Inhibits the Proliferation and Migration of Melanoma Cells by Regulating the Expression of Paxillin

OncoTargets and Therapy
Progerin, the underlying cause of Hutchinson-Gilford Progeria Syndrome (HGPS), has been extensively studied for its impact on normal cells and premature aging patients. However, there is a lack of research on its specific effects on tumor cells. Melanoma is one of the most common malignant tumors with high morbidity and mortality.
Weixian Liu, Xinxian Huang, Weizhao Luo, Xinguang Liu, Weichun Chen   +4 more
openaire   +3 more sources

Confocal fluorescence microscopy with false colour showing the localization of progerin (green) in nuclei (blue) in human myogenic cells.

, 2014
In HGPS fibroblast cultures, progerin positive nuclei are mostly lobulated or trabeculated (A–C). Human myogenic cells transfected with PMOs also demonstrated abnormally shaped progerin reactive nuclei (D–F: transfected with 1 µM PMO 421; G–I: 0.5 µM PMO
Steve D. Wilton (190383), Abbie M. Adams (572075), Yue-Bei Luo (572074), Sue Fletcher (77445), Frank L. Mastaglia (572077), Chalermchai Mitrpant (405121), Russell D. Johnsen (572076)   +6 more
core   +1 more source

PCR strategy for the detection of progerin expression in heart and blood.

, 2018
A Schematic overview of PCR based strategy to analyze progerin mRNA expression in human heart and the blood samples. Shown are the consensus donor splice sequence at the end of exon 11, the sequence of the normal LMNA cryptic splice site, and two common ...
Santhosh Kumar Ghadge (5150576), Andreas Wimmer (2813278), Valentina Goetsch (5150567), Moritz Messner (5150570), Jakob Dörler (5150573), Gerhard Pölzl (5150579), Marc-Michael Zaruba (5150564)   +6 more
core   +1 more source

Generation and characterization of an isogenic gene-corrected iPSC line CARIMi009-A-1 from a Hutchinson-Gilford Progeria Syndrome (HGPS) patient with a heterozygous G608G mutation in the LMNA gene

Stem Cell Research
Hutchinson-Gilford Progeria Syndrome (HGPS) is an ultra-rare systemic laminopathy caused by a heterozygous point mutation in the LMNA gene encoding Lamin A/C (c.1824C > T, p.G608G).
Giuliana Lezzoche, Evangelia Ntotsia, Sandrine Seyen, Federica De Majo, Servé Olieslagers, Dylan Mostert, Leon J. de Windt   +6 more
doaj   +1 more source

Progerin phosphorylation in interphase is lower and less mechanosensitive than lamin-A,C in iPS-derived mesenchymal stem cells

, 2018
Interphase phosphorylation of lamin-A,C depends dynamically on a cell's microenvironment, including the stiffness of extracellular matrix. However, phosphorylation dynamics is poorly understood for diseased forms such as progerin, a permanently ...
Yuntao Xia (5577878), Sangkyun Cho (5577869), Dennis E. Discher (436172), Irena L. Ivanovska (5577875), Amal Abbas (5577872), Jerome Irianto (4902721), Manu Tewari (5577881)   +6 more
core   +1 more source

Senescent endothelial cells promote pathogenic neutrophil trafficking in inflamed tissues

EMBO Reports
Cellular senescence is a hallmark of advanced age and a major instigator of numerous inflammatory pathologies. While endothelial cell (EC) senescence is aligned with defective vascular functionality, its impact on fundamental inflammatory responses in ...
Loïc Rolas, Monja Stein, Anna Barkaway, Natalia Reglero-Real, Elisabetta Sciacca, Mohammed Yaseen, Haitao Wang, Laura Vazquez-Martinez, Matthew Golding, Isobel A Blacksell, Meredith J Giblin, Edyta Jaworska, Cleo L Bishop, Mathieu-Benoit Voisin, Carles Gaston-Massuet, Liliane Fossati-Jimack, Costantino Pitzalis, Dianne Cooper, Thomas D Nightingale, Carlos Lopez-Otin, Myles J Lewis, Sussan Nourshargh   +21 more
doaj   +1 more source

Progerin cross-linking stiffens the nucleus and impairs mechanosensation in Hutchinson-Gilford progeria syndrome. [PDF]

J Cell Sci
Srivastava LK, Ghagre A, Duchastel-Vassaramva I, Ehrlicher AJ.   +3 more
europepmc   +1 more source