Results 121 to 130 of about 2,732 (185)

Proximity-Labeling of Near Neighbors of Lamin A and Lamin A-Δ50 (PROGERIN). [PDF]

, 2013
In an attempt to isolate and identify proteins that differentially interact with or locate near lamin A and progerin, we used a previously described method named BioID (proximity-dependent biotin identification).
Sabri, Mohammad
core   +1 more source

Atherosclerosis in progeria: insight from new mouse models with systemic and tissue-specific progerin expression [PDF]

, 2019
Tesis doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Medicina, Departamento de Bioquímica. Fecha de lectura: 19-09-2017Esta tesis tiene embargado el acceso al texto completo hasta el 19-03-2019Cardiovascular disease (CVD) is
Hamczyk, Magda Rita
core  

Senescent endothelial cells promote pathogenic neutrophil trafficking in inflamed tissues

EMBO Reports
Cellular senescence is a hallmark of advanced age and a major instigator of numerous inflammatory pathologies. While endothelial cell (EC) senescence is aligned with defective vascular functionality, its impact on fundamental inflammatory responses in ...
Loïc Rolas, Monja Stein, Anna Barkaway, Natalia Reglero-Real, Elisabetta Sciacca, Mohammed Yaseen, Haitao Wang, Laura Vazquez-Martinez, Matthew Golding, Isobel A Blacksell, Meredith J Giblin, Edyta Jaworska, Cleo L Bishop, Mathieu-Benoit Voisin, Carles Gaston-Massuet, Liliane Fossati-Jimack, Costantino Pitzalis, Dianne Cooper, Thomas D Nightingale, Carlos Lopez-Otin, Myles J Lewis, Sussan Nourshargh   +21 more
doaj   +1 more source

Progerin Expression Disrupts Critical Adult Stem Cell Functions that Mediate Tissue Repair Primarily through a Mechanism that Permanently Farnesylates Lamin A [PDF]

, 2017
Vascular disease is a leading cause of death worldwide. Vascular repair, essential for tissue maintenance, is critically reduced during vascular disease and aging.
Pacheco, Laurin
core  

A toxic STING-SAMHD1 axis drives replication stress in progeria and cancer cells. [PDF]

Nucleic Acids Res
Teodoro-Castro B, de Faria RC, Shashkova EV, Malique A, Adolph MB, Silva LND, Gonzalo S.   +6 more
europepmc   +1 more source

The Lamin Proteins in Nuclear Structure, Functions, and Laminopathies. [PDF]

Cells
Zhao G, Chen Z, Yang C, Liu M, Wang W, Zhang C.   +5 more
europepmc   +1 more source

Farnesylated prelamin A induces fibroblast polarity defects in premature aging disorders by inhibiting nesprin-2-SUN2 LINC complex function. [PDF]

J Cell Sci
Lio C, Wang Y, Wilson PC, Li Y, Antoku S, Östlund C, Shin JY, Worman HJ, Chang W, Gundersen GG.   +9 more
europepmc   +1 more source

Prelamin A in an <i>Lmna</i> ^L648R/L648R Mouse Model Does Not Promote Atherosclerosis or Vascular Smooth Muscle Loss. [PDF]

Arterioscler Thromb Vasc Biol
Wang Y, Joseph LC, Östlund C, Kuriakose G, Hsu W, Michaelis S, Worman HJ.   +6 more
europepmc   +1 more source

Exacerbated atherosclerosis in progeria is prevented by progerin elimination in vascular smooth muscle cells but not endothelial cells [PDF]

Hutchinson-Gilford progeria syndrome (HGPS) is a rare disease caused by the expression of progerin, a mutant protein that accelerates aging and precipitates death.
Nevado, RM, Gonzalo, P, Carmona, RM, Barettino, A, González-Gómez, C, Benedicto, I, Andrés-Manzano, MJ, de la Fuente-Pérez, M, Espinós-Estévez, C, Dorado, B, Rolas, L, Andrés, V, Hamczyk, MR, Nourshargh, S   +13 more
core  

LAV-BPIFB4 reverses progeria-associated cardiac aging by restoring diastolic function and reducing senescence. [PDF]

Int J Biol Sci
Chae U, Park YH, Kwon T, Chung KS, Kim SU.   +4 more
europepmc   +1 more source