Results 131 to 140 of about 3,816 (187)

Endothelial cell-specific progerin expression does not cause cardiovascular alterations and premature death. [PDF]

Aging Cell
AbstractHutchinson‐Gilford progeria syndrome (HGPS) is a rare genetic disorder caused by a mutation in the LMNA gene that provokes the synthesis of progerin, a mutant version of the nuclear protein lamin A that accelerates aging and precipitates death.
Benedicto I, Hamczyk MR, Nevado RM, Barettino A, Carmona RM, Espinós-Estévez C, Gonzalo P, de la Fuente-Pérez M, Andrés-Manzano MJ, González-Gómez C, Dorado B, Andrés V.   +11 more
europepmc   +6 more sources

Validation of modulated proteins due to progerin over-expression in Progeria Syndrome (HGPS) cell lines [PDF]

, 2015
El síndrome de la progeria de Hutchinson-Gilford (HGPS), una enfermedad de envejecimiento prematuro, se caracteriza por la sobreexpresión de una isoforma mutada de la lamina A, la progerina o lamina AΔ50.
Palla Pérez, Sandra
core   +1 more source

A combination of both proteomic and genetic approach to indentify de-regulated pathway in progeria, an accelerated aging disorder [PDF]

, 2011
Comunicaciones a ...
Arufe, M.C., Blanco, Francisco J., Calamia, Valentina, Fernández, P., Fuente, A. de la, Lesende, I., Mateos, Jesús, Rocha, Beatriz, Ruiz-Romero, Cristina   +8 more
core  

Induced pluripotent stem cell models of frontotemporal dementia [PDF]

, 2016
The increasing prevalence of dementia in the ageing population combined with the lack of treatments and the burden on national healthcare systems globally, make dementia a public health priority.
Hardy, J, Preza, E, Warner, T, Wray, S
core  

Vascular cells derived from Hutchinson-Gilford progeria syndrome (HGPS) inducible pluripotent stem cells [PDF]

, 2014
To study the vulnerability of smooth muscle cells (SMCs) in Hutchinson-Gilford Progeria Syndrome (HGPS)
Ferreira, Lino, Nissan, Xavier, Pitrez, Patricia R., Rocha, I., Vazão, Helena   +4 more
core  

Senescent endothelial cells promote pathogenic neutrophil trafficking in inflamed tissues

EMBO Reports
Cellular senescence is a hallmark of advanced age and a major instigator of numerous inflammatory pathologies. While endothelial cell (EC) senescence is aligned with defective vascular functionality, its impact on fundamental inflammatory responses in ...
Loïc Rolas, Monja Stein, Anna Barkaway, Natalia Reglero-Real, Elisabetta Sciacca, Mohammed Yaseen, Haitao Wang, Laura Vazquez-Martinez, Matthew Golding, Isobel A Blacksell, Meredith J Giblin, Edyta Jaworska, Cleo L Bishop, Mathieu-Benoit Voisin, Carles Gaston-Massuet, Liliane Fossati-Jimack, Costantino Pitzalis, Dianne Cooper, Thomas D Nightingale, Carlos Lopez-Otin, Myles J Lewis, Sussan Nourshargh   +21 more
doaj   +1 more source

LAV-BPIFB4 reverses progeria-associated cardiac aging by restoring diastolic function and reducing senescence. [PDF]

Int J Biol Sci
Chae U, Park YH, Kwon T, Chung KS, Kim SU.   +4 more
europepmc   +1 more source

Why and How Are Infants with Hutchinson-Gilford Progeria Syndrome Born Without Severe Manifestations? [PDF]

Med Sci (Basel)
Erokhina MA, Vorotelyak EA, Vasiliev AV, Abdyev VK.   +3 more
europepmc   +1 more source

Potential therapeutic approaches for modulating expression and accumulation of defective lamin A in laminopathies and age-related diseases [PDF]

, 2012

core   +1 more source

Hutchinson-Gilford progeria syndrome alters the endothelial genetic response to laminar shear stress. [PDF]

Front Physiol
Kennedy CC, Carter JL, Truskey GA.
europepmc   +1 more source