Results 41 to 50 of about 1,264,892 (364)

Dissecting the effect of sphingolipid metabolism gene in progression and microenvironment of osteosarcoma to develop a prognostic signature

Frontiers in Endocrinology, 2022
Sphingolipid metabolism (SM) fuels tumorigenesis and the malignant progression of osteosarcoma (OS), which leads to an unfavorable prognosis. Elucidating the molecular mechanisms underlying SM in osteosarcoma and developing a SM-based prognostic ...
Yujian Zhong, Yubiao Zhang, S. Wei, Junwen Chen, C. Zhong, W. Cai, Wenyi Jin, Hao Peng   +7 more
semanticscholar   +1 more source

A bile acid-related prognostic signature in hepatocellular carcinoma

Scientific Reports, 2022
Due to the high mortality of hepatocellular carcinoma (HCC), its prognostic models are urgently needed. Bile acid (BA) metabolic disturbance participates in hepatocarcinogenesis. We aim to develop a BA-related gene signature for HCC patients.
Wang Zhang, Yue Zhang, Yipeng Wan, Qi Liu, Xuan-jin Zhu   +4 more
semanticscholar   +1 more source

Identification of Potential Prognostic Long Non-Coding RNA Biomarkers for Predicting Survival in Patients with Hepatocellular Carcinoma

Cellular Physiology and Biochemistry, 2018
Background/Aims: The aim of the current study was to identify potential prognostic long non-coding RNA (lncRNA) biomarkers for predicting survival in patients with hepatocellular carcinoma (HCC) using The Cancer Genome Atlas (TCGA) dataset and ...
Xiwen Liao, Chengkun Yang, Rui Huang, Chuangye Han, Tingdong Yu, Ketuan Huang, Xiaoguang Liu, Long Yu, Guangzhi Zhu, Hao Su, Xiangkun Wang, Wei Qin, Jianlong Deng, Xianmin Zeng, Xinping Ye, Tao Peng   +15 more
doaj   +1 more source

Development and validation of a robust immune-related prognostic signature in early-stage lung adenocarcinoma

Journal of Translational Medicine, 2020
Background The incidence of stage I and stage II lung adenocarcinoma (LUAD) is likely to increase with the introduction of annual screening programs for high-risk individuals. We aimed to identify a reliable prognostic signature with immune-related genes
Pancheng Wu, Yi Zheng, Yanyu Wang, Yadong Wang, Naixin Liang   +4 more
doaj   +1 more source

Identification of a Four-Gene-Based SERM Signature for Prognostic and Drug Sensitivity Prediction in Gastric Cancer

Frontiers in Oncology, 2022
BackgroundGastric cancer (GC) is a highly molecular heterogeneous tumor with poor prognosis. Epithelial-mesenchymal transition (EMT) process and cancer stem cells (CSCs) are reported to share common signaling pathways and cause poor prognosis in GC ...
Xiya Jia, Xiya Jia, Bing Chen, Bing Chen, Ziteng Li, Ziteng Li, Shenglin Huang, Shenglin Huang, Siyuan Chen, Siyuan Chen, Runye Zhou, Runye Zhou, Wanjing Feng, Wanjing Feng, Hui Zhu, Hui Zhu, Xiaodong Zhu, Xiaodong Zhu   +17 more
doaj   +1 more source

m6A-Related Angiogenic Genes to Construct Prognostic Signature, Reveal Immune and Oxidative Stress Landscape, and Screen Drugs in Hepatocellular Carcinoma

Oxidative Medicine and Cellular Longevity, 2022
Background. m6A modification plays a key role in the development of hepatocellular carcinoma (HCC). Angiogenesis‐related genes (ARGs) are increasingly being used to define signatures predicting patient prognosis. The correlations between m6A‐related ARGs
Xiao-Yu Qu, Luyao Zhang, Songbo Li, Tian Li, Xingyu Zhao, Na Wang, Yongquan Shi   +6 more
semanticscholar   +1 more source

Whole transcriptome signature for prognostic prediction (WTSPP): application of whole transcriptome signature for prognostic prediction in cancer

Laboratory Investigation, 2020
Developing prognostic biomarkers for specific cancer types that accurately predict patient survival is increasingly important in clinical research and practice. Despite the enormous potential of prognostic signatures, proposed models have found limited implementations in routine clinical practice.
Schaafsma, Evelien, Zhao, Yanding, Wang, Yue, Varn, Frederick S., Zhu, Kenneth, Yang, Huan, Cheng, Chao   +6 more
openaire   +3 more sources

Apoptosis-related genes-based prognostic signature for osteosarcoma

Aging, 2022
Osteosarcoma (OS) is a common malignant primary tumor of skeleton, especially in children and adolescents, characterized by high lung metastasis rate. Apoptosis has been studied in various tumors, while the prognostic role of apoptosis-related genes in OS has been seldom studied.
Yang, Fei, Zhang, Yi
openaire   +2 more sources

Development and validation of a novel endoplasmic reticulum stress-related lncRNA prognostic signature and candidate drugs in breast cancer

Frontiers in Genetics, 2022
Breast cancer (BC), the most common malignancy in women, has a high cancer-related mortality. Endoplasmic reticulum stress (ERS), a response to the accumulation of unfolded proteins, has emerging roles in tumorigenesis, including invasion, metastasis ...
Jiehui Cai, Zeqi Ji, Jinyao Wu, Lingzhi Chen, D. Zheng, Yaokun Chen, Xinkang Zhang, W. Xie, Jie-An Huang, Manqiu Chen, R. Lin, Weixun Lin, Yexi Chen, Zhiyang Li   +13 more
semanticscholar   +1 more source

Identification of a pyroptosis-related prognostic signature in breast cancer

BMC Cancer, 2022
The relationship between pyroptosis and cancer is complex. It is controversial that whether pyroptosis represses or promotes tumor development. This study aimed to explore prognostic molecular characteristics to predict the prognosis of breast cancer ...
Hang-Yu Chen, Hai-hua Luo, Jieyan Wang, Jinming Li, Yong Jiang   +4 more
semanticscholar   +1 more source