Mycobacterial protein PE_PGRS30 induces macrophage apoptosis through prohibitin 2 mitochondrial function interference [PDF]
Frontiers in Microbiology, 2023 PE_PGRS30 belongs to the PE_PGRS protein family and is characterized by a conserved Pro-Glu (PE) domain and a typically polymorphic GC-rich sequence (PGRS) domain. PE_PGRS30 is a virulence factor of Mycobacterium tuberculosis that induces macrophage cell
Kazunori Matsumura +2 more
doaj +5 more sources
Prohibitin 2 orchestrates long noncoding RNA and gene transcription to accelerate tumorigenesis [PDF]
Nature CommunicationsThe spatial co-presence of aberrant long non-coding RNAs (lncRNAs) and abnormal coding genes contributes to malignancy development in various tumors. However, precise coordinated mechanisms underlying this phenomenon in tumorigenesis remains incompletely
Tianyi Ding +10 more
doaj +5 more sources
Prohibitin 2 deficiency impairs cardiac fatty acid oxidation and causes heart failure [PDF]
Cell Death and Disease, 2020 Fatty acids are the most major substrate source for adult cardiac energy generation. Prohibitin 2 (PHB2), a highly conserved protein located in mitochondrial inner membrane, plays key roles in cellular energy metabolic homeostasis. However, its functions
Qi Peng, Chuan-Yun Li, Heping Cheng
exaly +6 more sources
Prohibitin 2 Is an Inner Mitochondrial Membrane Mitophagy Receptor [PDF]
Cell, 2017 The removal of unwanted or damaged mitochondria by autophagy, a process called mitophagy, is essential for key events in development, cellular homeostasis, tumor suppression, and prevention of neurodegeneration and aging. However, the precise mechanisms of mitophagy remain uncertain.
Wei-Chung Chiang +2 more
exaly +6 more sources
Prohibitin 2 ameliorates cisplatin-induced acute kidney injury by modulating mitochondrial homeostasis [PDF]
Frontiers in PhysiologyAcute kidney injury (AKI), associated with a major health burden globally, is frequently caused by nephrotoxic agents, specifically cisplatin. Prohibitin (PHB) 2, a highly conserved mitochondrial protein localized at the inner mitochondrial membrane, is ...
Qi Zhang +4 more
doaj +3 more sources
Astragaloside IV alleviates septic myocardial injury through DUSP1-Prohibitin 2 mediated mitochondrial quality control and ER-autophagy [PDF]
Journal of Advanced ResearchIntroduction: Septic cardiomyopathy (SCM) is a complication of myocardial injury in patients with severe sepsis. Objectives: This study highlights the potential of Astragaloside IV(AS) in the treatment of septic cardiomyopathy and provides a reference ...
Junyan Wang +7 more
doaj +3 more sources
CRISPR-editing of the virus vector Aedes albopictus cell line C6/36, illustrated by prohibitin 2 gene knockout [PDF]
MethodsXAedes mosquitoes are important virus vectors. We provide a toolkit for CRISPR-Cas9-editing of difficult-to-knockdown gene previously shown to be refractory to siRNA silencing in mosquito cells, which is pivotal in understanding vector biology, vector ...
Shiu-Wan Chan
doaj +3 more sources
The reticulocyte restriction: invasion ligand RBP1a of Plasmodium vivax targets human TfR1, prohibitin-2, and basigin [PDF]
Frontiers in Cellular and Infection MicrobiologyIntroductionPlasmodium vivax is the most widespread cause of malaria outside Africa. Developing effective controls is challenging because P. vivax exclusively invades reticulocytes, immature erythrocytes that are scarce and short-lived.
Jessica Molina-Franky +11 more
doaj +3 more sources
Prohibitin 2 is Involved in Parkin-Mediated Mitophagy in Urothelial Cells of Cattle Infected with Bovine Papillomavirus [PDF]
Pathogens, 2020 Prohibitin 2 (PHB2), an inner mitochondrial membrane (IMM) protein, has recently been identified as a novel receptor involved in parkin-mediated mitophagy.
Francesca De Falco +5 more
doaj +3 more sources
Inhibition of Prolyl Oligopeptidase Restores Prohibitin 2 Levels in Psychosis Models: Relationship to Cognitive Deficits in Schizophrenia. [PDF]
Int J Mol Sci, 2023 Cognitive impairment represents one of the core features of schizophrenia. Prolyl Oligopeptidase (POP) inhibition is an emerging strategy for compensating cognitive deficits in hypoglutamatergic states such as schizophrenia, although little is known ...
Vila È +10 more
europepmc +2 more sources