Results 11 to 20 of about 22,223,348 (210)

The Role of Prohibitin-2 in Diseases

Frontiers in Bioscience-Landmark, 2023
Prohibitin-2 (PHB2) is a conserved protein in mitochondria that regulates various biological processes, including cell cycle, proliferation, apoptosis, transcription, signal transduction, and mitochondrial ridge morphogenesis.
Fang Liu, You Zhang, Zhiyong Guo, An-Jing Ren   +3 more
doaj   +4 more sources

Functional role and molecular mechanisms underlying prohibitin 2 in platelet mitophagy and activation. [PDF]

Mol Med Rep, 2021
Platelet mitophagy is a major pathway involved in the clearance of injured mitochondria during hemostasis and thrombosis. Prohibitin 2 (PHB2) has recently emerged as an inner mitochondrial membrane receptor involved in mitophagy.
Hu LL, Zou K, Chen Y, Wu LJ, Cao J, Xiong XY, Wang L, Cheng XS, Xiao QZ, Yang RQ.   +9 more
europepmc   +6 more sources

Loss of prohibitin 2 in Schwann cells dysregulates key transcription factors controlling developmental myelination. [PDF]

Glia
Schwann cells are critical for the proper development and function of the peripheral nervous system (PNS), where they form a collaborative relationship with axons.
Wilson ER, Nunes GD, Shen S, Moore S, Gawron J, Maxwell J, Syed U, Hurley E, Lanka M, Qu J, Désaubry L, Wrabetz L, Poitelon Y, Feltri ML.   +13 more
europepmc   +7 more sources

Mitochondrial Aurora kinase A induces mitophagy by interacting with MAP1LC3 and Prohibitin 2. [PDF]

Life Sci Alliance, 2021
The multifunctional Ser/Thr kinase AURKA uses the Inner Mitochondrial Membrane receptor PHB2 and MAP1LC3 as a signalling platform to orchestrate the elimination of dysfunctional mitochondria.
Bertolin G, Alves-Guerra MC, Cheron A, Burel A, Prigent C, Le Borgne R, Tramier M.   +6 more
europepmc   +5 more sources

IGFBP6 orchestrates antiinfective immune collapse in murine sepsis via prohibitin-2-mediated immunosuppression. [PDF]

J Clin Invest
The persistent challenge of sepsis-related mortality underscores the necessity for deeper insights. Our multicenter, cross-age cohort study identified insulin-like growth factor binding protein 6 (IGFBP6) as a critical regulator in sepsis diagnosis ...
Chen K, Hu Y, Yu X, Tang H, Ruan Y, Li Y, Gao X, Zhao Q, Wang H, Zhang X, Molloy DP, Yin Y, Chen D, Song Z.   +13 more
europepmc   +3 more sources

Efficient PHB2 (prohibitin 2) exposure during mitophagy depends on VDAC1 (voltage dependent anion channel 1). [PDF]

Autophagy
Exposure of inner mitochondrial membrane resident protein PHB2 (prohibitin 2) during autophagic removal of depolarized mitochondria (mitophagy) depends on the ubiquitin-proteasome system.
Roy M, Nandy S, Marchesan E, Banerjee C, Mondal R, Caicci F, Ziviani E, Chakraborty J.   +7 more
europepmc   +5 more sources

Casein kinase 1 proteomics reveal prohibitin 2 function in molecular clock. [PDF]

PLoS ONE, 2012
Throughout the day, clock proteins synchronize changes in animal physiology (e.g., wakefulness and appetite) with external cues (e.g., daylight and food).
Lorna S Kategaya, Aisha Hilliard, Louying Zhang, John M Asara, Louis J Ptáček, Ying-Hui Fu   +5 more
doaj   +7 more sources

Overexpression of Prohibitin 2 Protein is Associated with Adverse Prognosis in Cytogenetically Normal Acute Myeloid Leukemia. [PDF]

Ann Lab Med, 2022
Cytogenetically normal acute myeloid leukemia (CN-AML) accounts for 40%–50% of all AML cases. Despite advances in understanding the molecular pathophysiology of CN-AML, its clinical outcome remains unsatisfactory and unpredictable.
Lee YE, Lim HJ, Park JH, Kim HR, Kang MG, Cho YK, Shin JH, Shin MG.   +7 more
europepmc   +2 more sources

RSU-1 interaction with prohibitin-2 links cell-extracellular matrix detachment to downregulation of ERK signaling. [PDF]

J Biol Chem, 2021
Cell–extracellular matrix (ECM) detachment is known to decrease extracellular signal–regulated kinase (ERK) signaling, an intracellular pathway that is central for control of cell behavior.
Wang M, Liu J, Tu Y, Zhao Z, Qu J, Chen K, Chen Y, Sun Y, Zhao H, Deng Y, Wu C.   +10 more
europepmc   +4 more sources

Erratum: Serum Prohibitin 2/PHB2 in Parkin-Mediated Mitophagy: A Potential Therapeutic Target for Non-Small Cell Lung Carcinoma. [PDF]

Med Sci Monit, 2022
The authors requested replacing Figure 2 as there was an error. The details of this error are as follows: Representative picture of transwell migration assay, A549 control group (Figure 2E).
Zhang H, Yin C, Liu X, Bai X, Wang L, Xu H, Ju J, Zhang L.   +7 more
europepmc   +2 more sources