Results 21 to 30 of about 22,223,348 (210)

Phosphoglycerate mutase 5 exacerbates alcoholic cardiomyopathy in male mice by inducing prohibitin-2 dephosphorylation and impairing mitochondrial quality control. [PDF]

Clin Transl Med
Background The induction of mitochondrial quality control (MQC) mechanisms is essential for the re‐establishment of mitochondrial homeostasis and cellular bioenergetics during periods of stress.
Tao J, Qiu J, Zheng J, Li R, Chang X, He Q.   +5 more
europepmc   +2 more sources

Pyruvate kinase M2 sustains cardiac mitochondrial quality surveillance in septic cardiomyopathy by regulating prohibitin 2 abundance via S91 phosphorylation. [PDF]

Cell Mol Life Sci
The endogenous mitochondrial quality control (MQC) system serves to protect mitochondria against cellular stressors. Although mitochondrial dysfunction contributes to cardiac damage during many pathological conditions, the regulatory signals influencing ...
Du Y, Li J, Dai Z, Chen Y, Zhao Y, Liu X, Xia T, Zhu P, Wang Y.   +8 more
europepmc   +2 more sources

Ligustrazine nano-drug delivery system ameliorates doxorubicin-mediated myocardial injury via piezo-type mechanosensitive ion channel component 1-prohibitin 2-mediated mitochondrial quality surveillance. [PDF]

J Nanobiotechnology
Doxorubicin (DOX) demonstrates significant therapeutic and anticancer efficacy. Nevertheless, it demonstrates significant cardiotoxicity, resulting in permanent cardiac damage.
Wang J, Zhuang H, Li C, Cai R, Shi H, Pang B, Guo Z, Ong SB, Nie Y, Du Y, Zhou H, Chang X.   +11 more
europepmc   +2 more sources

Dual-specificity phosphatase 1 interacts with prohibitin 2 to improve mitochondrial quality control against type-3 cardiorenal syndrome. [PDF]

Int J Med Sci
Type-3 cardiorenal syndrome (CRS-3) is acute kidney injury followed by cardiac injury/dysfunction. Mitochondrial injury may impair myocardial function during CRS-3. Since dual-specificity phosphatase 1 (DUSP1) and prohibitin 2 (PHB2) both promote cardiac
Liu N, Ding Y, Zhou H, Chang X, Lou L.
europepmc   +2 more sources

PHB2 (prohibitin 2) promotes PINK1-PRKN/Parkin-dependent mitophagy by the PARL-PGAM5-PINK1 axis. [PDF]

Autophagy, 2020
Mitophagy, which is a conserved cellular process for selectively removing damaged or unwanted mitochondria, is critical for mitochondrial quality control and the maintenance of normal cellular physiology.
Yan C, Gong L, Chen L, Xu M, Abou-Hamdan H, Tang M, Désaubry L, Song Z.   +7 more
europepmc   +2 more sources

Prohibitin 1 is essential to preserve mitochondria and myelin integrity in Schwann cells

Nature Communications, 2021
Prohibitin 2 can localize to the axon-Schwann-cell interface and is required for myelin formation. Here, the authors show that deletion of prohibitin 1 in Schwann cells instead triggers severe myelin loss likely caused by mitochondrial dysfunction, and ...
Gustavo Della Flora Nunes, Emma Wilson, Edward Hurley   +2 more
exaly   +2 more sources

SLAMF receptors negatively regulate B cell receptor signaling in chronic lymphocytic leukemia via recruitment of prohibitin-2. [PDF]

Leukemia, 2021
We identified a subset of Chronic Lymphocytic Leukemia (CLL) patients with high Signaling Lymphocytic Activation Molecule Family (SLAMF) receptor-related signaling that showed an indolent clinical course.
von Wenserski L, Schultheiß C, Bolz S, Schliffke S, Simnica D, Willscher E, Gerull H, Wolters-Eisfeld G, Riecken K, Fehse B, Altfeld M, Nollau P, Binder M.   +12 more
europepmc   +2 more sources

Prohibitin 2/PHB2 in Parkin-Mediated Mitophagy: A Potential Therapeutic Target for Non-Small Cell Lung Carcinoma. [PDF]

Med Sci Monit, 2020
Background Mitophagy, a selective autophagy process, plays various roles in tumors. Prohibitin 2 (PHB2) is an inner-mitochondrial membrane protein that participates in parkin-induced mitophagy.
Zhang H, Yin C, Liu X, Bai X, Wang L, Xu H, Ju J, Zhang L.   +7 more
europepmc   +2 more sources

Dihydromyricetin induces mitophagy by regulating Prohibitin 2 pathway in vascular endothelial cells

Di-san junyi daxue xuebao, 2022
Objective To observe the effects of dihydromyricetin on mitophagy in vascular endothelial cells, and to clarify the underlying role of Prohibitin 2 in the process.
HU Qin, SHEN Hui, ZHANG Ting, LI Yafei
doaj   +2 more sources

Prohibitin 2 mRNA Downregulation in Breast Cancer Tumor Tissues [PDF]

Iranian Quarterly Journal of Breast Diseases, 2021
Introduction: Breast cancer is the most important cause of cancer mortality among women, therefore the study of its causative or aggravating factors seems necessary. In this study, the mRNA levels of the PHB2 gene were evaluated in tumor and adjacent non-
Z. Shaghaghi Torkdari, M. Khalaj-Kondori, M. Hosseinpour   +2 more
semanticscholar   +2 more sources