Results 41 to 50 of about 22,223,348 (210)

Involvement of prohibitin 1 and prohibitin 2 upregulation in cBSA-induced podocyte cytotoxicity.

Journal of Food and Drug Analysis, 2020
Membranous nephropathy (MN) is the most common cause of nephrotic syndrome in adults, when not effectively treated. The aim of this study was to discover new targets for the diagnosis and treatment of MN. A reliable mouse model of MN was used by the administration of cationic bovine serum albumin (cBSA).
Heng-Hsiung Wu, Chao-Jung Chen, P. Lin, Yu-Huei Liu   +3 more
semanticscholar   +3 more sources

CaMK IV phosphorylates prohibitin 2 and regulates prohibitin 2-mediated repression of MEF2 transcription. [PDF]

Cell Signal, 2011
Prohibitin 2 (PHB2) is an evolutionarily conserved and ubiquitously expressed multifunctional protein which is present in various cellular compartments including the nucleus. However, mechanisms underlying various functions of PHB2 are not fully explored yet.
Sun L, Cao X, Liu B, Huang H, Wang X, Sui L, Yin W, Ma K.   +7 more
europepmc   +3 more sources

Immunohistochemical activity of Prohibitin-2 and Stomatin-Like Protein-2 in patients with ulcerative colitis [PDF]

The Turkish Journal of Gastroenterology, 2016
We aimed to semi-quantitatively investigate prohibitin-2 (Phb-2) and stomatin-like protein-2 (Slp-2) expressions in patients with ulcerative colitis (UC) and healthy controls using the immunohistochemical (IHC) method. We also aimed to evaluate the correlations between the activity of UC and the expressions of these two proteins.Ninety-five patients ...
Beyazit, YAVUZ, YAZGAN, Yusuf, ÖZARI, Halil Onur, Kaplan, MUSTAFA, AKYOL, Taner, KARA, Muammer, YILMAZ, Ismail, ÖNCÜ, Kemal, TANOGLU, Alpaslan, KÜÇÜK, Irfan   +9 more
  +8 more sources

Prohibitin-mediated lifespan and mitochondrial stress implicate SGK-1, insulin/IGF and mTORC2 in C. elegans. [PDF]

PLoS ONE, 2014
Lifespan regulation by mitochondrial proteins has been well described, however, the mechanism of this regulation is not fully understood. Amongst the mitochondrial proteins profoundly affecting ageing are prohibitins (PHB-1 and PHB-2).
Roxani Gatsi, Bettina Schulze, María Jesús Rodríguez-Palero, Blanca Hernando-Rodríguez, Ralf Baumeister, Marta Artal-Sanz   +5 more
doaj   +1 more source

Essential Protein PHB2 and Its Regulatory Mechanisms in Cancer

Cells, 2023
Prohibitins (PHBs) are a highly conserved class of proteins and have an essential role in transcription, epigenetic regulation, nuclear signaling, mitochondrial structural integrity, cell division, and cellular membrane metabolism.
Amanda Qi, Lillie Lamont, Evelyn Liu, Sarina D. Murray, Xiangbing Meng, Shujie Yang   +5 more
doaj   +1 more source

Nrf2/PHB2 alleviates mitochondrial damage and protects against Staphylococcus aureus‐induced acute lung injury

MedComm, 2023
Staphylococcus aureus (SA) is a major cause of sepsis, leading to acute lung injury (ALI) characterized by inflammation and oxidative stress. However, the role of the Nrf2/PHB2 pathway in SA‐induced ALI (SA‐ALI) remains unclear.
Si‐Hao Jin, Jiao‐Jiao Sun, Gang Liu, Li‐Juan Shen, Yuan Weng, Jin‐You Li, Min Chen, Ying‐Ying Wang, Zhi‐Qi Gao, Feng‐Juan Jiang, Sheng‐Peng Li, Dan Chen, Qing‐Feng Pang, Ya‐Xian Wu, Zhi‐Qiang Wang   +14 more
doaj   +1 more source

The pathogen Moniliophthora perniciosa promotes differential proteomic modulation of cacao genotypes with contrasting resistance to witches´ broom disease [PDF]

, 2020
Background: Witches' broom disease (WBD) of cacao (Theobroma cacao L.), caused by Moniliophthora perniciosa, is the most important limiting factor for the cacao production in Brazil.
Correa, Stephany Cristiane, Cruz dos Santos, Everton, Gramacho, Karina Peres, Micheli, Fabienne, Pirovani, Carlos Priminho   +4 more
core   +1 more source

Proteomic analysis of the rat ovary following chronic low-dose exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) [PDF]

, 2009
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a ubiquitously distributed endocrine-disrupting chemical and reproductive toxicant. In order to elucidate low-dose TCDD-mediated effects on reproductive or endocrine functions, female Sprague-Dawley rats were
Chen, X., Coenraads, P.J., Liu, J., Ma, S.W., Ma, X.M., Sun, M., Tang, N.J., Zhang, C.M., Zhao, L.J.   +8 more
core   +7 more sources

COMP-prohibitin 2 interaction maintains mitochondrial homeostasis and controls smooth muscle cell identity. [PDF]

Cell Death Dis, 2018
AbstractVascular smooth muscle cells (VSMCs) are highly phenotypically plastic, and loss of the contractile phenotype in VSMCs has been recognized at the early onset of the pathology of a variety of vascular diseases. However, the endogenous regulatory mechanism to maintain contractile phenotype in VSMCs remains elusive. Moreover, little has been known
Jia Y, Wang M, Mao C, Yu F, Wang Y, Xiao R, Jiang C, Zheng L, Xu Q, Zheng M, Fu Y, Hu Q, Kong W.   +12 more
europepmc   +5 more sources

Prohibitin/annexin 2 interaction regulates fatty acid transport in adipose tissue [PDF]

JCI Insight, 2016
We have previously identified prohibitin (PHB) and annexin A2 (ANX2) as proteins interacting on the surface of vascular endothelial cells in white adipose tissue (WAT) of humans and mice. Here, we demonstrate that ANX2 and PHB also interact in adipocytes.
Ahmad, Salameh, Alexes C, Daquinag, Daniela I, Staquicini, Zhiqiang, An, Katherine A, Hajjar, Renata, Pasqualini, Wadih, Arap, Mikhail G, Kolonin   +7 more
openaire   +2 more sources