Results 61 to 70 of about 24,430,487 (196)
Journal of Dairy Science: Mitochondrial dysfunction has been reported to occur in the mammary gland of dairy cows suffering from ketosis. Prohibitin 2 (PHB2) plays a crucial role in regulating mitophagy, which clears impaired mitochondria to maintain normal mitochondrial ...
Guojin Li +12 more
doaj +1 more source
The Interferon-Inducible Mouse Apolipoprotein L9 and Prohibitins Cooperate to Restrict Theiler's Virus Replication. [PDF]
PLoS ONE, 2015 Apolipoprotein L9b (Apol9b) is an interferon-stimulated gene (ISG) that has antiviral activity and is weakly expressed in primary mouse neurons as compared to other cell types.
Marguerite Kreit +3 more
doaj +1 more source
The sorting nexin Snx21 promotes flotillin‐mediated endocytosis
The FEBS Journal, EarlyView.In this study, we describe a novel function of the previously uncharacterized Snx21 protein as a specific positive regulator of flotillin‐mediated endocytic trafficking. Snx21 is recruited to endosomal membranes via binding to PI(3)P, and it colocalizes with flotillins on the surface of late endosomes.
Tamás Maruzs +9 more
wiley +1 more source
Journal of Dairy Science: Excessive nonesterified fatty acids (NEFA) during the transition period impose metabolic stress on the bovine mammary gland. High NEFA levels induce oxidative stress and trigger apoptosis in bovine mammary epithelial cells.
Guojin Li +13 more
doaj +1 more source
CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems
The FEBS Journal, EarlyView.Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén +11 more
wiley +1 more source
Mitochondrial Functions and Estrogen Receptor-dependent Nuclear Translocation of Pleiotropic Human Prohibitin 2 [PDF]
Journal of Biological Chemistry, 2006 Proteins with multiple cellular functions provide biological diversity to eukaryotic cells. In the current studies, we identified the mitochondrial functions of human prohibitin 2 (PHB2), which was initially identified as a repressor of estrogen-dependent transcriptional activity.
Katsumi, Kasashima +3 more
openaire +2 more sources
Opposing function of mitochondrial prohibitin in aging [PDF]
, 2016 This is an open‐access article distributed under the terms of the Creative Commons Attribution License.While specific signalling cascades involved in aging, such as the insulin/IGF‐1 pathway, are well‐described, the actual metabolic changes they elicit ...
Artal-Sanz, Marta +1 more
core +1 more source
Prohibitin Links Cell Cycle, Motility and Invasion in Prostate Cancer Cells [PDF]
, 2023 Prohibitin (PHB) is a tumour suppressor gene with several different molecular activities. PHB overexpression leads to G1/S-phase cell cycle arrest, and PHB represses the androgen receptor (AR) in prostate cancer cells.
Jiang, W.G. +3 more
core +1 more source
Generation and characterization of pancreatic ß-Cell specific Prohibitin-2 knockout mice
, 2013 Prohibitin-2 (Phb-2) controls mitochondrial dynamics and apoptosis. In pancreatic ß-cells, mitochondria play a pivotal role in the control of insulin secretion. In this work, we investigated the role of Prohibitin 2 (Phb2) and mitochondrial dynamics in ß-
Supale, Sachin
core +1 more source
Bakuchiol: From structural mimicry to systems‐level skin biology
International Journal of Cosmetic Science, EarlyView.Convergent outcomes, divergent mechanisms: bakuchiol vs. retinol. Bakuchiol exhibits functional convergence with retinol in improving extracellular matrix integrity, epidermal differentiation and barrier function, while operating through distinct mechanisms.
Ratan K. Chaudhuri
wiley +1 more source