The prohibitin-binding compound fluorizoline inhibits mitophagy in cancer cells
Oncogenesis, 2021 Fluorizoline is a prohibitin-binding compound that triggers apoptosis in several cell lines from murine and human origin, as well as in primary cells from hematologic malignancies by inducing the integrated stress response and ER stress. Recently, it was
Sonia Núñez-Vázquez +9 more
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Renal Failure, 2013 Prohibitin (PHB), a ubiquitous protein, plays a number of different molecular functions, and it is mainly located on the inner mitochondrial membrane and nuclei.
Tian-Biao, Zhou, Yuan-Han, Qin
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An Unusual Prohibitin Regulates Malaria Parasite Mitochondrial Membrane Potential
Cell Reports, 2018 Summary: Proteins of the stomatin/prohibitin/flotillin/HfIK/C (SPFH) family are membrane-anchored and perform diverse cellular functions in different organelles.
Joachim Michael Matz +3 more
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Mitochondrial fusion and Bid-mediated mitochondrial apoptosis are perturbed by alcohol with distinct dependence on its metabolism [PDF]
, 2018 Environmental stressors like ethanol (EtOH) commonly target mitochondria to influence the cell’s fate. Recent literature supports that chronic EtOH exposure suppresses mitochondrial dynamics, central to quality control, and sensitizes mitochondrial ...
Hajnóczky, György +4 more
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Mitochondrial dysfunction and adipogenic reduction by prohibitin silencing in 3T3-L1 cells. [PDF]
PLoS ONE, 2012 Increase in mitochondrial biogenesis has been shown to accompany brown and white adipose cell differentiation. Prohibitins (PHBs), comprised of two evolutionarily conserved proteins, prohibitin-1 (PHB1) and prohibitin-2 (PHB2), are present in a high ...
Dong Liu +9 more
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Intramolecular Cyclization of N-phenyl N'(2-chloroethyl)ureas leads to Active N-phenyl-4,5-dihydrooxazol-2-amines Alkylating β-Tubulin Glu198 and Prohibitin Asp40 [PDF]
, 2011 International audienceThe cyclization of anticancer drugs into active intermediates has been reported mainly for DNA alkylating molecules including nitrosoureas.
Bouchon, Bernadette +10 more
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Translation inhibition by rocaglates is independent of eIF4E phosphorylation status [PDF]
, 2016 Rocaglates are natural products that inhibit protein synthesis in eukaryotes and exhibit antineoplastic activity. In vitro biochemical assays, affinity chromatography experiments coupled with mass spectrometry analysis, and in vivo genetic screens have ...
Cencic, Regina +4 more
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Sensitization of renal carcinoma cells to TRAIL-induced apoptosis by rocaglamide and analogs [PDF]
, 2018 Rocaglamide has been reported to sensitize several cell types to TRAIL-induced apoptosis. In recent years, advances in synthetic techniques have led to generation of novel rocaglamide analogs.
Brown, Lauren E. +5 more
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Imaging Findings of Paratesticular Adenomatoid Tumor. [PDF]
Clin Case RepABSTRACT Paratesticular adenomatoid tumors are benign growths usually found near the epididymis. They often show no symptoms and appear as hyperechoic masses on ultrasound. Magnetic resonance imaging helps in difficult cases. Surgical removal is curative with minimal recurrence risk.
Liu W, Yuan Z, Liang L, Leng X.
europepmc +2 more sources
Virulence, 2022 The vegetative insecticidal proteins (Vip3A) secreted by some Bacillus thuringiensis (Bt) strains during vegetative growth are regarded as a new generation of insecticidal toxins. Like insecticidal crystal proteins, they are also used in transgenic crops
Baoju An +5 more
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