Results 101 to 110 of about 2,450 (184)

Decorin transfection induces proteomic and phenotypic modulation in breast cancer cells 8701-BC [PDF]

, 2008
Decorin is a prototype member of the small leucine-rich proteoglycan family widely distributed in the extracellular matrices of many connective tissues, where it has been shown to play multiple important roles in the matrix assembly process, as well as ...
Cancemi P, Di Cara G, Feo S, Forlino A, Martini D, Minafra L, Minafra S., Pucci-minafra Ida, Ruggeri A, Tenni R, Tira Me   +10 more
core   +1 more source

Dual‐Targeted Glucose‐Dependent Insulinotropic Polypeptide‐Loaded Photothermal Nanoparticles to Prevent Obesity via Lipolysis and Browning of White Adipose Tissue

Small Science, Volume 5, Issue 11, November 2025.
Current weight‐loss medications inevitably cause adverse effects such as depression or muscle loss. The developed GIP/ICG@P/R8 NPs specifically promoted energy expenditure by inducing browning, lipolysis and apoptosis of WAT in vitro and in vivo. The results showed a 9.23% weight reduction after 14 days, enhanced insulin sensitivity, improved fatty ...
Ting Xie, Lutang Zhao, Shurui Pei, Kaikai Wen, Sijia Fei, Wan Chen, Zhengyang Li, Long Zhang, Linlin Li, Lixin Guo, Hui Huang, Qi Pan   +11 more
wiley   +1 more source

The emerging roles of prohibitins in folliculogenesis

Frontiers in Bioscience, 2012
Prohibitins are members of a highly conserved eukaryotic protein family containing the stomatin/prohibitin/flotillin/HflK/C (SPFH) domain (also known as the prohibitin (PHB) domain) found in divergent species from prokaryotes to eukaryotes. Prohibitins are found in unicellular eukaryotes, fungi, plants, animals and humans.
Indrajit, Chowdhury, Minerva, Garcia-Barrio, Djana, Harp, Kelwyn, Thomas, Roland, Matthews, Winston E, Thompson   +5 more
openaire   +2 more sources

Patterns and Processes of Genomic Evolution Inferred From the Ten Smallest Vertebrate Genomes

Advanced Science, Volume 12, Issue 38, October 13, 2025.
By integrating phylogenetic relationships derived from nuclear DNA with population genetic analyses across ten pufferfish species, the genetic differentiation mechanisms underpinning the radiative speciation of the most compact vertebrate genomes has elucidated.
Kaiqiang Liu, Qian Wang, Ning Wang, Lingfeng Meng, Shuo Li, Hong‐Yan Wang, Yuyan Liu, Qian Liu, Yangqing Zhang, Lucas B. Doretto, Mengqi Zhang, Yating Qin, Shanshan Pan, Shenglei Han, Weijing Li, Shanshan Liu, Fengtao Gao, Axel Meyer, Jussi Taipale, Guangyi Fan, Manfred Schartl, Jilin Zhang, Changwei Shao   +22 more
wiley   +1 more source

Opposing function of mitochondrial prohibitin in aging

Aging, 2010
While specific signalling cascades involved in aging, such as the insulin/IGF-1 pathway, are well-described, the actual metabolic changes they elicit to prolong lifespan remain obscure. Nevertheless, the tuning of cellular metabolism towards maximal survival is the molecular basis of longevity.
Artal-Sanz, Marta, Tavernarakis, Nektarios   +1 more
openaire   +4 more sources

Survey of Human Mitochondrial Diseases Using New Genomic/Proteomic Tools [PDF]

, 2001
BACKGROUND. We have constructed Bayesian prior-based, amino-acid sequence profiles for the complete yeast mitochondrial proteome and used them to develop methods for identifying and characterizing the context of protein mutations that give rise to human ...
Mohr, Scott C., Plasterer, Thomas N., Smith, Temple F.   +2 more
core   +2 more sources

Emerging Nanonutraceuticals against Obesity

Small Science, Volume 5, Issue 10, October 2025.
This overview comprehensively compiles the latest research advancements in diversiform nanonutraceuticals against obesity. These nanonutraceuticals are derived from the nanomodifications of some carbohydrates, lipids, proteins, vitamins, minerals, and phytochemicals.
Linjie Ni, Minmin Peng, Yiying Liang, Xiwen Ye, Hanying Zheng, Dongbei Guo, Liang Yang, Xusangni Li, Ronghe Chen   +8 more
wiley   +1 more source

Developmentally regulated HEART STOPPER, a mitochondrially targeted L18 ribosomal protein gene, is required for cell division, differentiation, and seed development in Arabidopsis. [PDF]

, 2015
Evidence is presented for the role of a mitochondrial ribosomal (mitoribosomal) L18 protein in cell division, differentiation, and seed development after the characterization of a recessive mutant, heart stopper (hes).
Ashton, A., Chaudhury, A., Day, R., Hrmova, M., Ivanova, A., Koltunow, A., Luo, M., Macknight, R., Talbot, M., Zhang, H.   +9 more
core   +1 more source

IgG4‐Related Disease: Emerging Roles of Novel Genetic Variants, Immune Cell Subsets and Therapeutic Targets

Allergy, Volume 80, Issue 10, Page 2738-2754, October 2025.
ABSTRACT IgG4, the least abundant IgG subclass in humans, is increasingly recognised for its involvement in allergic and autoimmune pathologies. Its unique properties, such as the tendency to form half‐molecules (one heavy chain and one light chain) and its generally non‐inflammatory nature, distinguish it from other IgG subclasses.
Louisa Tedesco, Syed B. Ali, Baran Erman, Safa Baris, Harshita Pant, Pravin Hissaria, Yelda Bilginer, Damon J. Tumes, Gökhan Cildir   +8 more
wiley   +1 more source

Characterization of the functions and proteomes associated with membrane rafts in chicken sperm [PDF]

, 2017
Cellular membranes are heterogeneous, and this has a great impact on cellular function. Despite the central role of membrane functions in multiple cellular processes in sperm, their molecular mechanisms are poorly understood.
Asano Atsushi, Ishikawa Naoto, Tajima Atsushi, Ushiyama Ai, 浅野 敦之, 田島 淳史, 石川 尚人   +6 more
core   +1 more source