Results 11 to 20 of about 8,202 (220)

Novel Assays to Distinguish Between Properdin-Dependent and Properdin-Independent C3 Nephritic Factors Provide Insight Into Properdin-Inhibiting Therapy [PDF]

Frontiers in Immunology, 2019
C3 glomerulopathy (C3G) is an umbrella classification for severe renal diseases characterized by predominant staining for complement component C3 in the glomeruli. The disease is caused by a dysregulation of the alternative pathway (AP) of the complement
Marloes A. H. M. Michels, Nicole C. A. J. van de Kar, Ramon M. van den Bos, Thea J. A. M. van der Velden, Sanne A. W. van Kraaij, Sebastian A. Sarlea, Valentina Gracchi, Michiel J. S. Oosterveld, Elena B. Volokhina, Elena B. Volokhina, Lambertus P. W. J. van den Heuvel, Lambertus P. W. J. van den Heuvel, Lambertus P. W. J. van den Heuvel   +12 more
doaj   +8 more sources

Soluble collectin-12 mediates C3-independent docking of properdin that activates the alternative pathway of complement

eLife, 2020
Properdin stabilizes the alternative C3 convertase (C3bBb), whereas its role as pattern-recognition molecule mediating complement activation is disputed for decades.
Jie Zhang, Lihong Song, Dennis V Pedersen, Anna Li, John D Lambris, Gregers Rom Andersen, Tom Eirik Mollnes, Ying Jie Ma, Peter Garred   +8 more
doaj   +2 more sources

Properdin Is a Modulator of Tumour Immunity in a Syngeneic Mouse Melanoma Model

Medicina, 2021
Background and Objectives: Tumours are often low immunogenic. The role of complement, an innate immune defence system, in tumour control has begun to be elucidated, but findings are conflicting. A role for properdin, an amplifier of complement activation,
Izzat A. M. Al-Rayahi, Lee R. Machado, Cordula M. Stover   +2 more
doaj   +2 more sources

Properdin Is a Key Player in Lysis of Red Blood Cells and Complement Activation on Endothelial Cells in Hemolytic Anemias Caused by Complement Dysregulation

Frontiers in Immunology, 2020
The complement system alternative pathway (AP) can be activated excessively in inflammatory diseases, particularly when there is defective complement regulation.
Jin Y. Chen, Neeti S. Galwankar, Heather N. Emch, Smrithi S. Menon, Claudio Cortes, Joshua M. Thurman, Samuel A. Merrill, Robert A. Brodsky, Viviana P. Ferreira   +8 more
doaj   +2 more sources

Complement Properdin Determines Disease Activity in MRL/lpr Mice

Medicina, 2020
Background and objects: In systemic lupus erythematosus, circulating immune complexes activate complement and, when trapped in renal capillaries, cause glomerulonephritis.
Hasanain Alaridhee, Azzah Alharbi, Zeayd Saeed, Róisín C. Thomas, Cordula M. Stover   +4 more
doaj   +2 more sources

Alternative Complement Pathway in Carotid Atherosclerosis: Low Plasma Properdin Levels Associate With Long‐Term Cardiovascular Mortality [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Complement activation may promote atherosclerosis. Yet, data on the to which extent complement, and more specifically the alternative complement pathway, is activated in patients with carotid atherosclerosis and related to adverse outcome in ...
Mieke C. Louwe, Chrysostomi Gialeli, Annika E. Michelsen, Sverre Holm, Andreas Edsfeldt, Karolina Skagen, Tove Lekva, Maria Belland Olsen, Vigdis Bjerkeli, Therese Schjørlien, Kristine Stø, Xiang Yi Kong, Tuva B. Dahl, Per H. Nilsson, Peter Libby, Pål Aukrust, Tom Eirik Mollnes, Thor Ueland, Mona Skjelland, Isabel Gonçalves, Bente Halvorsen   +20 more
doaj   +2 more sources

The Role of Properdin in Killing of Non-Pathogenic Leptospira biflexa

Frontiers in Immunology, 2020
Properdin (P) is a positive regulatory protein that stabilizes the C3 convertase and C5 convertase of the complement alternative pathway (AP). Several studies have suggested that properdin can bind directly to the surface of certain pathogens regardless ...
Adriana Patricia Granados Martinez, Patrícia Antonia Estima Abreu, Silvio de Arruda Vasconcellos, Paulo Lee Ho, Viviana P. Ferreira, Gurpanna Saggu, Angela Silva Barbosa, Lourdes Isaac   +7 more
doaj   +2 more sources

Linkage Specificity and Role of Properdin in Activation of the Alternative Complement Pathway by Fungal Glycans [PDF]

mBio, 2011
Fungal cell walls are predominantly composed of glucans, mannans, and chitin. Recognition of these glycans by the innate immune system is a critical component of host defenses against the mycoses.
Sarika Agarwal, Charles A. Specht, Haibin Huang, Gary R. Ostroff, Sanjay Ram, Peter A. Rice, Stuart M. Levitz   +6 more
doaj   +2 more sources

Insights Into Enhanced Complement Activation by Structures of Properdin and Its Complex With the C-Terminal Domain of C3b

Frontiers in Immunology, 2019
Properdin enhances complement-mediated opsonization of targeted cells and particles for immune clearance. Properdin occurs as dimers, trimers and tetramers in human plasma, which recognize C3b-deposited surfaces, promote formation, and prolong the ...
Ramon M. van den Bos, Nicholas M. Pearce, Joke Granneman, T. Harma C. Brondijk, Piet Gros   +4 more
doaj   +2 more sources

Properdin Modulates Complement Component Production in Stressed Human Primary Retinal Pigment Epithelium Cells

Antioxidants, 2020
The retinal pigment epithelium (RPE) maintains visual function and preserves structural integrity of the retina. Chronic dysfunction of the RPE is associated with retinal degeneration, including age-related macular degeneration (AMD).
Nicole Schäfer, Hannah N. Wolf, Anne Enzbrenner, Juliane Schikora, Maria Reichenthaler, Volker Enzmann, Diana Pauly   +6 more
doaj   +2 more sources