Protective Role for Properdin in Progression of Experimental Murine Atherosclerosis [PDF]
, 2013 Genetic, dietary and immune factors contribute to the pathogenesis of atherosclerosis in humans and mice. Complement activation is an integral part of the innate immune defence but also shapes cellular responses and influences directly triglyceride ...
Byrne, S. +9 more
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Properdin Levels in Human Sepsis [PDF]
Frontiers in Immunology, 2015 Properdin is a normal serum protein that increases the production of complement activation products by binding C3b integral to convertase complexes and amplifying their activity at the site of activation. Thereby, it not only can aid in the resolution of infection but also contribute to tissue damage.
Stover, Cordula M. +4 more
openaire +5 more sources
Linkage Specificity and Role of Properdin in Activation of the Alternative Complement Pathway by Fungal Glycans [PDF]
, 2011 Fungal cell walls are predominantly composed of glucans, mannans, and chitin. Recognition of these glycans by the innate immune system is a critical component of host defenses against the mycoses.
Agarwal +52 more
core +2 more sources
Novel approaches in complement profiling; application in kidney transplantation [PDF]
, 2022 The first choice for patients with end-stage kidney failure is transplantation. Complement activation plays an important role in the cause of kidney failure after transplantation.
Lammerts, Rosa
core +1 more source
Polymorphisms in genes related to the complement system and antibody-mediated cardiac allograft rejection [PDF]
, 2017 [Abstract] Background. Heart transplantation (HT) is a life-saving treatment for patients with end-stage heart failure. One of the main problems after HT is the humoral response termed antibody-mediated rejection (AMR).
Barge-Caballero, Eduardo +13 more
core +2 more sources
Properdin has an ascendancy over factor H regulation in complement-mediated renal tubular damage [PDF]
, 2014 BACKGROUND: Urinary (U)-complement components have been detected in patients with proteinuric renal diseases, and complement activation via the alternative pathway (AP) is believed to play a role in renal tubular damage.
Atsuko Hisada +10 more
core +1 more source
Immunologic aspects of the nephrotic syndrome [PDF]
, 1973 The nephrotic syndrome is a clinical entity characterized by proteinuria, hypoalbuminemia, edema and hyperlipidemia. All the features of this syndrome are ultimately related to increased permeability of the glomerular capillary to protein.
Michael, Alfred F. +6 more
core +4 more sources
The Journal of Experimental Medicine, 1974 The protein in the properdin pathway responsible for conversion of precursor factor D to D has been isolated and found to be identical with properdin. Sequential ion exchange and gel filtration chromatography demonstrated identity between properdin protein, measured by radial immunodiffusion, and the capacity to activate D to D, assessed by formation ...
Douglas T. Fearon +2 more
openaire +3 more sources
Insights Into Enhanced Complement Activation by Structures of Properdin and Its Complex With the C-Terminal Domain of C3b [PDF]
, 2019 Properdin enhances complement-mediated opsonization of targeted cells and particles for immune clearance. Properdin occurs as dimers, trimers and tetramers in human plasma, which recognize C3b-deposited surfaces, promote formation, and prolong the ...
+13 more
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Crotamine/siRNA Nanocomplexes for Functional Downregulation of Syndecan-1 in Renal Proximal Tubular Epithelial Cells [PDF]
, 2023 Proteinuria drives progressive tubulointerstitial fibrosis in native and transplanted kidneys, mainly through the activation of proximal tubular epithelial cells (PTECs).
Campeiro, Joana D’Arc +3 more
core +1 more source