Results 11 to 20 of about 11,905 (245)
THE PROPERDIN SYSTEM AND IMMUNITY [PDF]
The Journal of Experimental Medicine, 1956 A detailed method for the zymosan assay of properdin is described, together with procedures for the preparation and standardization of reagents employed in the test. The reliability and reproducibility of the assay, as well as its limitations, are discussed.
Earl W. Todd +4 more
+15 more sources
The Journal of Experimental Medicine, 1974 The protein in the properdin pathway responsible for conversion of precursor factor D to D has been isolated and found to be identical with properdin. Sequential ion exchange and gel filtration chromatography demonstrated identity between properdin protein, measured by radial immunodiffusion, and the capacity to activate D to D, assessed by formation ...
Douglas T. Fearon +2 more
openaire +5 more sources
Human Properdin Released By Infiltrating Neutrophils Can Modulate Influenza A Virus Infection [PDF]
Frontiers in Immunology, 2021 The complement system is designed to recognise and eliminate invading pathogens via activation of classical, alternative and lectin pathways. Human properdin stabilises the alternative pathway C3 convertase, resulting in an amplification loop that leads ...
Praveen M. Varghese +14 more
doaj +2 more sources
Properdin Pattern Recognition on Proximal Tubular Cells Is Heparan Sulfate/Syndecan-1 but Not C3b Dependent and Can Be Blocked by Tick Protein Salp20 [PDF]
Frontiers in Immunology, 2020 Introduction: Proteinuria contributes to progression of renal damage, partly by complement activation on proximal tubular epithelial cells. By pattern recognition, properdin has shown to bind to heparan sulfate proteoglycans on tubular epithelium and can
Rosa G. M. Lammerts +6 more
doaj +2 more sources
Frontiers in Immunology, 2013 Properdin, the only positive regulatory protein of the complement system, acts as both a stabilizer of the alternative pathway convertases and as a selective pattern recognition molecule of certain microorganisms and host cells (i.e.
Claudio Cortes +2 more
exaly +3 more sources
PLoS ONE, 2014 The complement system is an essential part of the innate immune system by acting as a first line of defense which is stabilized by properdin, the sole known positive regulator of the alternative complement pathway. Dysregulation of complement can promote
Diana Pauly +2 more
exaly +3 more sources
Linkage Specificity and Role of Properdin in Activation of the Alternative Complement Pathway by Fungal Glycans [PDF]
mBio, 2011 Fungal cell walls are predominantly composed of glucans, mannans, and chitin. Recognition of these glycans by the innate immune system is a critical component of host defenses against the mycoses.
Sarika Agarwal +6 more
doaj +2 more sources
Frontiers in Immunology, 2019 Properdin enhances complement-mediated opsonization of targeted cells and particles for immune clearance. Properdin occurs as dimers, trimers and tetramers in human plasma, which recognize C3b-deposited surfaces, promote formation, and prolong the ...
Nicholas M Pearce +2 more
exaly +3 more sources
Complement Dysregulation in Obese Versus Nonobese Polycystic Ovary Syndrome Patients [PDF]
Cells, 2023 Introduction: Upregulation of complement system factors are reported to be increased in polycystic ovary syndrome (PCOS) and may be due to obesity and insulin resistance rather than inherently due to PCOS.
Alexandra E. Butler +3 more
doaj +2 more sources
Frontiers in Immunology, 2018 Development of nanoparticles as tissue-specific drug delivery platforms can be considerably influenced by the complement system because of their inherent pro-inflammatory and tumorigenic consequences.
Basudev Paudyal +2 more
exaly +3 more sources