Results 21 to 30 of about 10,182 (218)
eLife, 2020 Properdin stabilizes the alternative C3 convertase (C3bBb), whereas its role as pattern-recognition molecule mediating complement activation is disputed for decades.
Jie Zhang +8 more
doaj +2 more sources
Frontiers in Immunology, 2020 The complement system alternative pathway (AP) can be activated excessively in inflammatory diseases, particularly when there is defective complement regulation.
Jin Y. Chen +8 more
doaj +2 more sources
Complement Properdin Determines Disease Activity in MRL/lpr Mice
Medicina, 2020 Background and objects: In systemic lupus erythematosus, circulating immune complexes activate complement and, when trapped in renal capillaries, cause glomerulonephritis.
Hasanain Alaridhee +4 more
doaj +2 more sources
Properdin Is a Modulator of Tumour Immunity in a Syngeneic Mouse Melanoma Model
Medicina, 2021 Background and Objectives: Tumours are often low immunogenic. The role of complement, an innate immune defence system, in tumour control has begun to be elucidated, but findings are conflicting. A role for properdin, an amplifier of complement activation,
Izzat A. M. Al-Rayahi +2 more
doaj +2 more sources
Properdin and Factor H: Opposing Players on the Alternative Complement Pathway “See-Saw”
Frontiers in Immunology, 2013 Properdin and factor H are two key regulatory proteins having opposite functions in the alternative complement pathway. Properdin up-regulates the alternative pathway by stabilising the C3bBb complex, whereas factor H down-regulates the pathway by ...
Cordula M Stover +2 more
exaly +3 more sources
The Role of Properdin in Killing of Non-Pathogenic Leptospira biflexa
Frontiers in Immunology, 2020 Properdin (P) is a positive regulatory protein that stabilizes the C3 convertase and C5 convertase of the complement alternative pathway (AP). Several studies have suggested that properdin can bind directly to the surface of certain pathogens regardless ...
Adriana Patricia Granados Martinez +7 more
doaj +2 more sources
Scientific Reports, 2022 Sialic acids as the terminal caps of the cellular glycocalyx play an essential role in self-recognition and were shown to modulate complement processes via interaction between α2,3-linked sialic acids and complement factor H. Previously, it was suggested
Anahita Shahraz +9 more
doaj +2 more sources
Antioxidants, 2020 The retinal pigment epithelium (RPE) maintains visual function and preserves structural integrity of the retina. Chronic dysfunction of the RPE is associated with retinal degeneration, including age-related macular degeneration (AMD).
Nicole Schäfer +6 more
doaj +2 more sources
Complement Properdin Regulates the Metabolo-Inflammatory Response to a High Fat Diet
Medicina, 2020 Background and objectives: Overnutrition leads to a metabolic and inflammatory response that includes the activation of Complement. Properdin is the only amplifier of complement activation and increases the provision of complement activation products ...
Rόisín C. Thomas +4 more
doaj +2 more sources
PLoS ONE, 2014 The complement system is an essential part of the innate immune system by acting as a first line of defense which is stabilized by properdin, the sole known positive regulator of the alternative complement pathway. Dysregulation of complement can promote
Diana Pauly +2 more
exaly +3 more sources