Results 21 to 30 of about 8,235 (150)

Characterization of factors influencing on-chip complement activation to optimize parallel measurement of antibody and complement proteins on antigen microarrays. [PDF]

, 2012
Binding of immunoglobulins and complement fragments to targets of adaptive immune responses can be monitored using collections of arrayed antigens and is used to generate profiles of antibody binding and function. The collection of reliable data on these
Erdei, Anna, Hóbor, Renáta, Papp, Krisztián, Prechl, József, Végh, Péter   +4 more
core   +1 more source

Determination of Severity of Murine IgA Nephropathy by Glomerular Complement Activation by Aberrantly Glycosylated IgA and Immune Complexes [PDF]

, 2012
The pathogenic roles of glomerular deposition of components of the complement cascade in IgA nephropathy (IgAN) are not completely clarified. To investigate the pathologic role of complement pathways in IgAN, two IgAN-prone mouse models were examined ...
Brown, Rhubell, Hall, Stacy, Hashimoto, Azusa, Novak, Jan, Ohi, Hiroyuki, Ohsawa, Isao, Suzuki, Hitoshi, Suzuki, Yusuke, Tanaka, Yuichi, Tomino, Yasuhiko   +9 more
core   +1 more source

Autoantibodies to complement components in C3 glomerulopathy and atypical hemolytic uremic syndrome. [PDF]

, 2014
The alternative pathway of complement is implicated in the pathogenesis of several renal diseases, such as atypical hemolytic uremic syndrome, dense deposit disease and other forms of C3 glomerulopathy.
Józsi, Mihály, Lopez-Trascasa, M., Nozal, P., Prohászka, Zoltán, Reuter, S., Sanchez-Corral, P., Uzonyi, Barbara   +6 more
core   +1 more source

The Properdin System in Mice.

Experimental Biology and Medicine, 1960
SummaryInjection of complement (guinea pig serum) into the laboratory albino mouse failed to alter capacity of these animals to withstand parenterally induced bacterial infection with K. pneumoniae or S. typhimurium. Addition of complement to mouse serum failed to induce bactericidal activity in vitro.
Fred Miya, Stanley Marcus, Eugene H. Perkins   +2 more
openaire   +3 more sources

Age-related macular degeneration associated polymorphism rs10490924 in ARMS2 results in deficiency of a complement activator [PDF]

, 2017
Background Age-related macular degeneration (AMD) is the leading cause of blindness in developed countries. The polymorphism rs10490924 in the ARMS2 gene is highly associated with AMD and linked to an indel mutation (del443ins54), the latter inducing ...
Jacob, Saskia, Joussen, Antonia M. [u. v. m.], Lin, Yuchen, Micklisch, Sven   +3 more
core   +1 more source

Low molecular weight polysialic acid binds to properdin and reduces the activity of the alternative complement pathway [PDF]

, 2022
Sialic acids as the terminal caps of the cellular glycocalyx play an essential role in self-recognition and were shown to modulate complement processes via interaction between α2,3-linked sialic acids and complement factor H. Previously, it was suggested
Bungartz, Annemarie, Lackmann, Marie, Liao, Huan, Lin, Yuchen, Mbroh, Joshua, Neumann, Harald, Shahraz, Anahita, Skerka, Christine, Winkler, Jonas, Zipfel, Peter F.   +9 more
core   +1 more source

Blood protein adsorption onto chitosan [PDF]

, 2002
Chitosan was recently indicated to enhance osteogenesis, improve wound healing but to activate the coagulation and the complement systems. In the present study approximately 10nm thick chitosan film were prepared on aminopropyltriethoxysilane (APTES ...
Benesch, Johan, Tengvall, P.
core   +1 more source

Novel Assays to Distinguish Between Properdin-Dependent and Properdin-Independent C3 Nephritic Factors Provide Insight Into Properdin-Inhibiting Therapy [PDF]

Frontiers in Immunology, 2019
C3 glomerulopathy (C3G) is an umbrella classification for severe renal diseases characterized by predominant staining for complement component C3 in the glomeruli. The disease is caused by a dysregulation of the alternative pathway (AP) of the complement system. In more than half of C3G patients C3 nephritic factors (C3NeFs) are found.
Michels, Marloes A.H.M., van de Kar, Nicole C.A.J., van den Bos, Ramon M., van der Velden, Thea J.A.M., van Kraaij, Sanne A.W., Sarlea, Sebastian A., Gracchi, Valentina, Oosterveld, Michiel J.S., Volokhina, Elena B., van den Heuvel, Lambertus P.W.J., Berger, S., van den Born, J., Gros, P., van Kooten, C., Seelen, M., de Vries, A.   +15 more
openaire   +8 more sources

Proteomic analysis of plasma proteins during fentanyl withdrawal in ovariectomized female rats with and without estradiol

Journal of Neuroendocrinology, EarlyView.
Abstract Evidence from both clinical and preclinical studies indicates that females experience a faster progression to drug addiction and more severe addiction‐related health effects compared with males. Estradiol (E2) plays a critical role in these sex differences.
Patricia Sinclair, Navdeep S. Dhanjal, E. Blair Towers, Wendy J. Lynch, Nadine Kabbani   +4 more
wiley   +1 more source

Complement System Part I – Molecular Mechanisms of Activation and Regulation [PDF]

, 2015
Complement is a complex innate immune surveillance system, playing a key role in defense against pathogens and in host homeostasis. The complement system is initiated by conformational changes in recognition molecular complexes upon sensing danger ...
Lubka T. Roumenina, Nicolas S. Merle, Sarah Elizabeth Church, Veronique Fremeaux-Bacchi   +3 more
core   +2 more sources