Results 21 to 30 of about 6,114 (163)

Seventy Years Later: Systemic and Local Properdin in Atherosclerosis [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Jean F. Regal, Sherry D. Fleming
doaj   +2 more sources

Properdin Pattern Recognition on Proximal Tubular Cells Is Heparan Sulfate/Syndecan-1 but Not C3b Dependent and Can Be Blocked by Tick Protein Salp20

Frontiers in Immunology, 2020
Introduction: Proteinuria contributes to progression of renal damage, partly by complement activation on proximal tubular epithelial cells. By pattern recognition, properdin has shown to bind to heparan sulfate proteoglycans on tubular epithelium and can
Rosa G. M. Lammerts, Ditmer T. Talsma, Wendy A. Dam, Mohamed R. Daha, Marc A. J. Seelen, Stefan P. Berger, Jacob van den Born   +6 more
doaj   +1 more source

Properdin Deficiency Impairs Phagocytosis and Enhances Injury at Kidney Repair Phase Post Ischemia–Reperfusion

Frontiers in Immunology, 2021
Properdin, a positive regulator of complement alternative pathway, participates in renal ischemia–reperfusion (IR) injury and also acts as a pattern-recognition molecule affecting apoptotic T-cell clearance.
Yuanyuan Wu, Yuanyuan Wu, Zinah D. Zwaini, Nigel J. Brunskill, Nigel J. Brunskill, Xinyue Zhang, Hui Wang, Ravinder Chana, Cordula M. Stover, Bin Yang, Bin Yang   +10 more
doaj   +1 more source

The Role of Properdin in Killing of Non-Pathogenic Leptospira biflexa

Frontiers in Immunology, 2020
Properdin (P) is a positive regulatory protein that stabilizes the C3 convertase and C5 convertase of the complement alternative pathway (AP). Several studies have suggested that properdin can bind directly to the surface of certain pathogens regardless ...
Adriana Patricia Granados Martinez, Patrícia Antonia Estima Abreu, Silvio de Arruda Vasconcellos, Paulo Lee Ho, Viviana P. Ferreira, Gurpanna Saggu, Angela Silva Barbosa, Lourdes Isaac   +7 more
doaj   +1 more source

Complement Properdin Determines Disease Activity in MRL/lpr Mice

Medicina, 2020
Background and objects: In systemic lupus erythematosus, circulating immune complexes activate complement and, when trapped in renal capillaries, cause glomerulonephritis.
Hasanain Alaridhee, Azzah Alharbi, Zeayd Saeed, Róisín C. Thomas, Cordula M. Stover   +4 more
doaj   +1 more source

Soluble collectin-12 mediates C3-independent docking of properdin that activates the alternative pathway of complement

eLife, 2020
Properdin stabilizes the alternative C3 convertase (C3bBb), whereas its role as pattern-recognition molecule mediating complement activation is disputed for decades.
Jie Zhang, Lihong Song, Dennis V Pedersen, Anna Li, John D Lambris, Gregers Rom Andersen, Tom Eirik Mollnes, Ying Jie Ma, Peter Garred   +8 more
doaj   +1 more source

Properdin inhibition ameliorates hepatic ischemia/reperfusion injury without interfering with liver regeneration in mice

Frontiers in Immunology, 2023
Hepatic ischemia/reperfusion injury (IRI) often causes serious complications in liver surgeries, including transplantation. Complement activation seems to be involved in hepatic IRI; however, no complement-targeted intervention has been clinically ...
Jiro Kusakabe, Koichiro Hata, Tetsuya Tajima, Hidetaka Miyauchi, Xiangdong Zhao, Shoichi Kageyama, Tatsuaki Tsuruyama, Etsuro Hatano   +7 more
doaj   +1 more source

Endothelial Glycocalyx: The Missing Link Between Angiogenic Imbalance in Preeclampsia and Systemic Inflammation in HELLP Syndrome. [PDF]

Compr Physiol
Endothelial glycocalyx may be the missing link between angiogenic factors, inflammatory regulation, and endothelial maternal dysfunction in early‐onset preeclampsia and HELLP syndrome. ABSTRACT The pathophysiology of preeclampsia and HELLP syndrome relies on systemic vascular endothelial dysfunction, resulting from angiogenic imbalance due to abnormal ...
Atallah A, Sarda MN, McCarey C, Massardier J, Huissoud C.   +4 more
europepmc   +2 more sources

Novel Assays to Distinguish Between Properdin-Dependent and Properdin-Independent C3 Nephritic Factors Provide Insight Into Properdin-Inhibiting Therapy

Frontiers in Immunology, 2019
C3 glomerulopathy (C3G) is an umbrella classification for severe renal diseases characterized by predominant staining for complement component C3 in the glomeruli. The disease is caused by a dysregulation of the alternative pathway (AP) of the complement
Marloes A. H. M. Michels, Nicole C. A. J. van de Kar, Ramon M. van den Bos, Thea J. A. M. van der Velden, Sanne A. W. van Kraaij, Sebastian A. Sarlea, Valentina Gracchi, Michiel J. S. Oosterveld, Elena B. Volokhina, Elena B. Volokhina, Lambertus P. W. J. van den Heuvel, Lambertus P. W. J. van den Heuvel, Lambertus P. W. J. van den Heuvel   +12 more
doaj   +1 more source

HBSP improves kidney ischemia-reperfusion injury and promotes repair in properdin deficient mice via enhancing phagocytosis of tubular epithelial cells

Frontiers in Immunology, 2023
Phagocytosis plays vital roles in injury and repair, while its regulation by properdin and innate repair receptor, a heterodimer receptor of erythropoietin receptor (EPOR)/β common receptor (βcR), in renal ischaemia-reperfusion (IR) remains unclear ...
Yuanyuan Wu, Yuanyuan Wu, Lili Huang, Wenli Sai, Fei Chen, Yu Liu, Cheng Han, Joanna M. Barker, Zinah D. Zwaini, Mark P. Lowe, Nigel J. Brunskill, Nigel J. Brunskill, Bin Yang, Bin Yang   +13 more
doaj   +1 more source