Antioxidants, 2020 The retinal pigment epithelium (RPE) maintains visual function and preserves structural integrity of the retina. Chronic dysfunction of the RPE is associated with retinal degeneration, including age-related macular degeneration (AMD).
Volker Enzmann, Diana Pauly
exaly +3 more sources
Frontiers in Immunology, 2019 Properdin (FP) is a positive regulator of the immune system stimulating the activity of the proteolytically active C3 convertase C3bBb in the alternative pathway of the complement system. Here we present two crystal structures of FP and two structures of
Yong Wang +2 more
exaly +3 more sources
Characterization of the bispecific VHH antibody tarperprumig (ALXN1820) specific for properdin and designed for low-volume administration [PDF]
mAbsThe bispecific antibody tarperprumig (ALXN1820) was developed as a treatment option for diseases involving dysregulated complement alternative pathway (AP) activity that could be administered in small volumes, either subcutaneously or intravenously ...
Paul Tamburini +8 more
doaj +2 more sources
Low molecular weight polysialic acid binds to properdin and reduces the activity of the alternative complement pathway [PDF]
Scientific Reports, 2022 Sialic acids as the terminal caps of the cellular glycocalyx play an essential role in self-recognition and were shown to modulate complement processes via interaction between α2,3-linked sialic acids and complement factor H. Previously, it was suggested
Anahita Shahraz +9 more
doaj +2 more sources
Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of ALXN1820 (Tarperprumig) in Healthy Adults: Results of a Phase I Study. [PDF]
Clin Transl SciABSTRACT Properdin is an endogenous positive regulator of the complement alternative pathway (AP). Tarperprumig (ALXN1820), a novel humanized bispecific antibody, binds properdin and albumin and is being developed to treat complement‐mediated diseases.
Sandhu A +8 more
europepmc +2 more sources
An Alternative Hypothesis for the ‘Properdin System’ [PDF]
Acta Haematologica, 1958 Robert A. Nelson
openaire +4 more sources
Endothelial Glycocalyx: The Missing Link Between Angiogenic Imbalance in Preeclampsia and Systemic Inflammation in HELLP Syndrome. [PDF]
Compr PhysiolEndothelial glycocalyx may be the missing link between angiogenic factors, inflammatory regulation, and endothelial maternal dysfunction in early‐onset preeclampsia and HELLP syndrome. ABSTRACT The pathophysiology of preeclampsia and HELLP syndrome relies on systemic vascular endothelial dysfunction, resulting from angiogenic imbalance due to abnormal ...
Atallah A +4 more
europepmc +2 more sources
Seventy Years Later: Systemic and Local Properdin in Atherosclerosis [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseJean F. Regal, Sherry D. Fleming
doaj +2 more sources
Frontiers in Immunology, 2023 Properdin acts as an essential positive regulator of the alternative pathway of complement by stabilizing enzymatic convertases. Identical properdin monomers form head-to-tail associations of oligomers in a reported 20:54:26 ratio (most often described ...
Sara R. Moore +5 more
doaj +1 more source
Proteomic analysis of plasma proteins during fentanyl withdrawal in ovariectomized female rats with and without estradiol. [PDF]
J NeuroendocrinolAbstract Evidence from both clinical and preclinical studies indicates that females experience a faster progression to drug addiction and more severe addiction‐related health effects compared with males. Estradiol (E2) plays a critical role in these sex differences.
Sinclair P +4 more
europepmc +2 more sources