Results 21 to 30 of about 8,202 (220)

Urinary Properdin and sC5b-9 Are Independently Associated With Increased Risk for Graft Failure in Renal Transplant Recipients

Frontiers in Immunology, 2019
The pathophysiology of late kidney-allograft failure remains complex and poorly understood. Activation of filtered or locally produced complement may contribute to the progression of renal failure through tubular C5b-9 formation.
Rosa G. M. Lammerts, Michele F. Eisenga, Mohammed Alyami, Mohamed R. Daha, Marc A. Seelen, Robert A. Pol, Jacob van den Born, Jan-Stephan Sanders, Stephan J. L. Bakker, Stefan P. Berger   +9 more
doaj   +2 more sources

Complement Properdin Regulates the Metabolo-Inflammatory Response to a High Fat Diet

Medicina, 2020
Background and objectives: Overnutrition leads to a metabolic and inflammatory response that includes the activation of Complement. Properdin is the only amplifier of complement activation and increases the provision of complement activation products ...
Rόisín C. Thomas, Ramiar Kheder, Hasanain Alaridhee, Naomi Martin, Cordula M. Stover   +4 more
doaj   +2 more sources

Widely Used Commercial ELISA Does Not Detect Precursor of Haptoglobin2, but Recognizes Properdin as a Potential Second Member of the Zonulin Family

Frontiers in Endocrinology, 2018
BackgroundThere is increasing evidence for the role of impaired intestinal permeability in obesity and associated metabolic diseases. Zonulin is an established serum marker for intestinal permeability and identical to pre-haptoglobin2.
Lucas Scheffler, Alyce Crane, Henrike Heyne, Anke Tönjes, Dorit Schleinitz, Christian H. Ihling, Michael Stumvoll, Rachel Freire, Maria Fiorentino, Alessio Fasano, Peter Kovacs, John T. Heiker   +11 more
doaj   +2 more sources

THE PROPERDIN SYSTEM AND IMMUNITY [PDF]

The Journal of Experimental Medicine, 1956
A detailed method for the zymosan assay of properdin is described, together with procedures for the preparation and standardization of reagents employed in the test. The reliability and reproducibility of the assay, as well as its limitations, are discussed.
Ralph Wedgwood, Harold S. Ginsberg, Louis Pillemer   +2 more
  +15 more sources

Properdin levels in human sepsis [PDF]

Frontiers in Immunology, 2015
Properdin is a normal serum protein which increases the production of complement activation products by binding to C3b integral to convertase complexes and amplifying their activity at the site of activation.
Cordula M Stover, John eMcDonald, Simon eByrne, David G Lambert, Jonathan eThompson   +4 more
doaj   +5 more sources

Properdin: A Novel Target for Neuroprotection in Neonatal Hypoxic-Ischemic Brain Injury

Frontiers in Immunology, 2019
Background: Hypoxic-ischemic (HI) encephalopathy is a major cause of neonatal mortality and morbidity, with a global incidence of 3 per 1,000 live births.
Claudia Sisa, Qudsiyah Agha-Shah, Balpreet Sanghera, Ariela Carno, Cordula Stover, Mariya Hristova   +5 more
doaj   +2 more sources

Structural Basis for Properdin Oligomerization and Convertase Stimulation in the Human Complement System

Frontiers in Immunology, 2019
Properdin (FP) is a positive regulator of the immune system stimulating the activity of the proteolytically active C3 convertase C3bBb in the alternative pathway of the complement system. Here we present two crystal structures of FP and two structures of
Dennis V. Pedersen, Trine A. F. Gadeberg, Caroline Thomas, Yong Wang, Nicolas Joram, Rasmus K. Jensen, Sofia M. M. Mazarakis, Margot Revel, Carine El Sissy, Steen V. Petersen, Kresten Lindorff-Larsen, Steffen Thiel, Nick S. Laursen, Véronique Fremeaux-Bacchi, Gregers R. Andersen   +14 more
doaj   +2 more sources

Human Properdin Modulates Macrophage: Mycobacterium bovis BCG Interaction via Thrombospondin Repeats 4 and 5

Frontiers in Immunology, 2018
Mycobacterium tuberculosis can proficiently enter macrophages and diminish complement activation on its cell surface. Within macrophages, the mycobacterium can suppress macrophage apoptosis and survive within the intracellular environment. Previously, we
Maha Ahmed Al-Mozaini, Maha Ahmed Al-Mozaini, Anthony G. Tsolaki, Munirah Abdul-Aziz, Munirah Abdul-Aziz, Suhair M. Abozaid, Suhair M. Abozaid, Mohammed N. Al-Ahdal, Ansar A. Pathan, Valarmathy Murugaiah, Evgeny M. Makarov, Anuvinder Kaur, Robert B. Sim, Uday Kishore, Lubna Kouser   +14 more
doaj   +2 more sources

Human Properdin Opsonizes Nanoparticles and Triggers a Potent Pro-inflammatory Response by Macrophages without Involving Complement Activation

Frontiers in Immunology, 2018
Development of nanoparticles as tissue-specific drug delivery platforms can be considerably influenced by the complement system because of their inherent pro-inflammatory and tumorigenic consequences.
Lubna Kouser, Basudev Paudyal, Basudev Paudyal, Anuvinder Kaur, Gudrun Stenbeck, Lucy A. Jones, Suhair M. Abozaid, Cordula M. Stover, Emmanuel Flahaut, Robert B. Sim, Uday Kishore   +10 more
doaj   +2 more sources

Complement Dysregulation in Obese Versus Nonobese Polycystic Ovary Syndrome Patients [PDF]

Cells, 2023
Introduction: Upregulation of complement system factors are reported to be increased in polycystic ovary syndrome (PCOS) and may be due to obesity and insulin resistance rather than inherently due to PCOS.
Alexandra E. Butler, Abu Saleh Md Moin, Thozhukat Sathyapalan, Stephen L. Atkin   +3 more
doaj   +2 more sources