Properdin: a tightly regulated critical inflammatory modulator [PDF]
Immunological Reviews, 2016 The complement alternative pathway is a powerful arm of the innate immune system that enhances diverse inflammatory responses in the human host. Key to the effects of the alternative pathway is properdin, a serum glycoprotein that can both initiate and ...
Adam Z. Blatt +2 more
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Blocking Properdin Prevents Complement-Mediated Hemolytic Uremic Syndrome and Systemic Thrombophilia [PDF]
Journal of the American Society of Nephrology, 2018 Background Properdin (P) is a positive regulator of the alternative pathway of complement activation. Although P inhibition is expected and has been shown to ameliorate the alternative pathway of complement-mediated tissue injury in several disease ...
Yoshiyasu Ueda +7 more
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Characterization of the bispecific VHH antibody tarperprumig (ALXN1820) specific for properdin and designed for low-volume administration [PDF]
mAbsThe bispecific antibody tarperprumig (ALXN1820) was developed as a treatment option for diseases involving dysregulated complement alternative pathway (AP) activity that could be administered in small volumes, either subcutaneously or intravenously ...
Paul Tamburini +8 more
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Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of ALXN1820 (Tarperprumig) in Healthy Adults: Results of a Phase I Study. [PDF]
Clin Transl SciABSTRACT Properdin is an endogenous positive regulator of the complement alternative pathway (AP). Tarperprumig (ALXN1820), a novel humanized bispecific antibody, binds properdin and albumin and is being developed to treat complement‐mediated diseases.
Sandhu A +8 more
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An Alternative Hypothesis for the ‘Properdin System’ [PDF]
Acta Haematologica, 1958 Robert A. Nelson
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The Journal of Experimental Medicine, 1974 The protein in the properdin pathway responsible for conversion of precursor factor D to D has been isolated and found to be identical with properdin. Sequential ion exchange and gel filtration chromatography demonstrated identity between properdin protein, measured by radial immunodiffusion, and the capacity to activate D to D, assessed by formation ...
Douglas T. Fearon +2 more
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Regulation of the terminal complement cascade in adipose tissue for control of its volume, cellularity, and fibrosis. [PDF]
Obesity (Silver Spring)Abstract White adipose tissue (WAT) is a reservoir for various pathogens and their products, such as lipopolysaccharides. Therefore, it must be equipped with a defense mechanism connected with the activation of innate immunity. This explains the phenomenon that adipocytes express components of the classical and alternative complement pathways, which ...
Kruglikov IL, Scherer PE.
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Seventy Years Later: Systemic and Local Properdin in Atherosclerosis [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseJean F. Regal, Sherry D. Fleming
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Immunological Reviews, 2022 Structures of alternative pathway proteins have offered a comprehensive structural basis for understanding the molecular mechanisms governing activation and regulation of the amplification pathway of the complement cascade.
D. Pedersen +2 more
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Properdin oligomers adopt rigid extended conformations supporting function
eLife, 2021 Properdin stabilizes convertases formed upon activation of the complement cascade within the immune system. The biological activity of properdin depends on the oligomerization state, but whether properdin oligomers are rigid and how their structure links
Dennis V Pedersen +6 more
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