Results 31 to 40 of about 10,182 (218)

Properdin levels in human sepsis [PDF]

Frontiers in Immunology, 2015
Properdin is a normal serum protein which increases the production of complement activation products by binding to C3b integral to convertase complexes and amplifying their activity at the site of activation.
Cordula M Stover, John eMcDonald, Simon eByrne, David G Lambert, Jonathan eThompson   +4 more
doaj   +4 more sources

Widely Used Commercial ELISA Does Not Detect Precursor of Haptoglobin2, but Recognizes Properdin as a Potential Second Member of the Zonulin Family

Frontiers in Endocrinology, 2018
BackgroundThere is increasing evidence for the role of impaired intestinal permeability in obesity and associated metabolic diseases. Zonulin is an established serum marker for intestinal permeability and identical to pre-haptoglobin2.
Lucas Scheffler, Alyce Crane, Henrike Heyne, Anke Tönjes, Dorit Schleinitz, Christian H. Ihling, Michael Stumvoll, Rachel Freire, Maria Fiorentino, Alessio Fasano, Peter Kovacs, John T. Heiker   +11 more
doaj   +2 more sources

Properdin: A Novel Target for Neuroprotection in Neonatal Hypoxic-Ischemic Brain Injury

Frontiers in Immunology, 2019
Background: Hypoxic-ischemic (HI) encephalopathy is a major cause of neonatal mortality and morbidity, with a global incidence of 3 per 1,000 live births.
Claudia Sisa, Qudsiyah Agha-Shah, Balpreet Sanghera, Ariela Carno, Cordula Stover, Mariya Hristova   +5 more
doaj   +2 more sources

Corrigendum: HBSP improves kidney ischemia-reperfusion injury and promotes repair in properdin deficient mice via enhancing phagocytosis of tubular epithelial cells [PDF]

Frontiers in Immunology, 2023
Yuanyuan Wu, Yuanyuan Wu, Lili Huang, Wenli Sai, Fei Chen, Yu Liu, Cheng Han, Joanna M. Barker, Zinah D. Zwaini, Mark P. Lowe, Nigel J. Brunskill, Nigel J. Brunskill, Bin Yang, Bin Yang   +13 more
doaj   +2 more sources

Properdin and factor H production by human dendritic cells modulates their T‐cell stimulatory capacity and is regulated by IFN‐γ [PDF]

European Journal of Immunology, 2017
Karen O Dixon, Cees van Kooten
exaly   +2 more sources

Properdin [PDF]

Definitions, 2020
Properdin (469 aa, ~51 kDa) is encoded by the human CFP gene. This protein plays a role in the stabilization of complement convertases of the alternative pathway.
openaire   +2 more sources

Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of ALXN1820 (Tarperprumig) in Healthy Adults: Results of a Phase I Study. [PDF]

Clin Transl Sci
ABSTRACT Properdin is an endogenous positive regulator of the complement alternative pathway (AP). Tarperprumig (ALXN1820), a novel humanized bispecific antibody, binds properdin and albumin and is being developed to treat complement‐mediated diseases.
Sandhu A, Shen T, Herrero PM, Yuan CX, Qureshi S, Jiang X, Sheng Y, Gasteyger C, Dai Y.   +8 more
europepmc   +2 more sources

Functional and structural insight into properdin control of complement alternative pathway amplification [PDF]

EMBO Journal, 2017
Dennis Pedersen, Lubka T. Roumenina, Rasmus K. Jensen, Trine AF Gadeberg, Chiara Marinozzi, Capucine Pïcard, Tania Rybkine, Steffen Thiel, Uffe B. Skov Sørensen, Cordula Stover, Véronique Frémeaux‐Bacchi, G.R. Andersen   +11 more
openalex   +2 more sources

Recurrent Gonococcemia Reveiling X-linked Properdin Deficiency: A Novel Case Report. [PDF]

Open Forum Infect Dis
Chedal-Anglay C, Vindrios W.
europepmc   +3 more sources

Seventy Years Later: Systemic and Local Properdin in Atherosclerosis [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Jean F. Regal, Sherry D. Fleming
doaj   +2 more sources