Results 31 to 40 of about 6,114 (163)

A novel antibody against human properdin inhibits the alternative complement system and specifically detects properdin from blood samples.

PLoS ONE, 2014
The complement system is an essential part of the innate immune system by acting as a first line of defense which is stabilized by properdin, the sole known positive regulator of the alternative complement pathway. Dysregulation of complement can promote
Diana Pauly, Benedikt M Nagel, Jörg Reinders, Tobias Killian, Matthias Wulf, Susanne Ackermann, Boris Ehrenstein, Peter F Zipfel, Christine Skerka, Bernhard H F Weber   +9 more
doaj   +1 more source

Proteomic analysis of plasma proteins during fentanyl withdrawal in ovariectomized female rats with and without estradiol. [PDF]

J Neuroendocrinol
Abstract Evidence from both clinical and preclinical studies indicates that females experience a faster progression to drug addiction and more severe addiction‐related health effects compared with males. Estradiol (E2) plays a critical role in these sex differences.
Sinclair P, Dhanjal NS, Towers EB, Lynch WJ, Kabbani N.   +4 more
europepmc   +2 more sources

Properdin Is a Modulator of Tumour Immunity in a Syngeneic Mouse Melanoma Model

Medicina, 2021
Background and Objectives: Tumours are often low immunogenic. The role of complement, an innate immune defence system, in tumour control has begun to be elucidated, but findings are conflicting. A role for properdin, an amplifier of complement activation,
Izzat A. M. Al-Rayahi, Lee R. Machado, Cordula M. Stover   +2 more
doaj   +1 more source

Linkage Specificity and Role of Properdin in Activation of the Alternative Complement Pathway by Fungal Glycans

mBio, 2011
Fungal cell walls are predominantly composed of glucans, mannans, and chitin. Recognition of these glycans by the innate immune system is a critical component of host defenses against the mycoses.
Sarika Agarwal, Charles A. Specht, Haibin Huang, Gary R. Ostroff, Sanjay Ram, Peter A. Rice, Stuart M. Levitz   +6 more
doaj   +1 more source

Complement Properdin Regulates the Metabolo-Inflammatory Response to a High Fat Diet

Medicina, 2020
Background and objectives: Overnutrition leads to a metabolic and inflammatory response that includes the activation of Complement. Properdin is the only amplifier of complement activation and increases the provision of complement activation products ...
Rόisín C. Thomas, Ramiar Kheder, Hasanain Alaridhee, Naomi Martin, Cordula M. Stover   +4 more
doaj   +1 more source

Variability and action mechanism of a family of anticomplement proteins in Ixodes ricinus. [PDF]

PLoS ONE, 2008
BACKGROUND: Ticks are blood feeding arachnids that characteristically take a long blood meal. They must therefore counteract host defence mechanisms such as hemostasis, inflammation and the immune response.
Bernard Couvreur, Jérôme Beaufays, Cédric Charon, Kathia Lahaye, François Gensale, Valérie Denis, Benoît Charloteaux, Yves Decrem, Pierre-Paul Prévôt, Michel Brossard, Luc Vanhamme, Edmond Godfroid   +11 more
doaj   +1 more source

The alternative pathway of complement activation may be involved in the renal damage of human anti-glomerular basement membrane disease. [PDF]

PLoS ONE, 2014
Linear deposition of IgG and complement 3 (C3) along glomerular basement membrane (GBM) is generally revealed in the kidneys of human anti-GBM disease. Our recent studies demonstrated the pathogenic role of complement activation in renal damage of this ...
Rui Ma, Zhao Cui, Shui-Yi Hu, Xiao-Yu Jia, Rui Yang, Xin Zheng, Jie Ao, Gang Liu, Yun-Hua Liao, Ming-Hui Zhao   +9 more
doaj   +1 more source

Complement Initiation Varies by Sex in Intestinal Ischemia Reperfusion Injury

Frontiers in Immunology, 2021
Intestinal ischemia reperfusion (IR)-induced tissue injury represents an acute inflammatory response with significant morbidity and mortality. The mechanism of IR-induced injury is not fully elucidated, but recent studies suggest a critical role for ...
Miaomiao Wu, Miaomiao Wu, Jennifer M. Rowe, Sherry D. Fleming   +3 more
doaj   +1 more source

Integrated Clinical Trial and Molecular Profiling Reveals Immune Drivers of Chronic Hand Eczema

Allergy, EarlyView.
This study performed an unbiased molecular profiling of CHE patients across diverse etiologies to identify shared pathogenic drivers and evaluate the impact of IL‐4Rα blockade via dupilumab over 16 weeks. CHE shows a mixed immune signature involving type 1, 2, and 3 pathways with features of atopic dermatitis and psoriasis.
Perrine Gery, Rüçhan Ekren, Emilie Bérard, Aurélie Du‐Thanh, Hugo Rimet, Fatma Jendoubi, Vanina Lenief, Nadia Raison‐Peyron, Amel Bouznad, Maria P. Konstantinou, Jonathan Rioual, Lilian Basso, Juliette Mouiren, Manon Boussier, Brigitte Milpied, Cristina Bulai Livideanu, Louise Jaulent, Florence Hacard, Marine A. Lefevre, Audrey Nosbaum, Julien Seneschal, Marc Vocanson, Carle Paul, Nicolas Gaudenzio, Marie Tauber, on behalf of the French Atopic Dermatitis Network from de GREAT Research group   +25 more
wiley   +1 more source

Urinary Properdin and sC5b-9 Are Independently Associated With Increased Risk for Graft Failure in Renal Transplant Recipients

Frontiers in Immunology, 2019
The pathophysiology of late kidney-allograft failure remains complex and poorly understood. Activation of filtered or locally produced complement may contribute to the progression of renal failure through tubular C5b-9 formation.
Rosa G. M. Lammerts, Michele F. Eisenga, Mohammed Alyami, Mohamed R. Daha, Marc A. Seelen, Robert A. Pol, Jacob van den Born, Jan-Stephan Sanders, Stephan J. L. Bakker, Stefan P. Berger   +9 more
doaj   +1 more source