Results 31 to 40 of about 8,235 (150)

Untersuchungen über Properdin

Zeitschrift für Naturforschung B, 1966
Mit einer neuen, mikrochemischen Analysenmethode wurden Untersuchungen über den Bildungsort des Properdins, die Beeinflussung des Wachstums von Impftumoren durch das Properdinsystem und die Wirkung von Cancerostatica wie Actinomycin C1, Mercaleukin, Colchicin, Honvan und Cyclophosphamid sowie Prednison und Desoxycorticosteronacetat auf die humorale ...
openaire   +3 more sources

Factor H-related protein 4 activates complement by serving as a platform for the assembly of alternative pathway C3 convertase via its interaction with C3b protein [PDF]

, 2012
Human complement factor H-related protein (CFHR) 4 belongs to the factor H family of plasma glycoproteins that are composed of short consensus repeat (SCR) domains.
Hebecker, Mario, Józsi, Mihály
core   +1 more source

Exosome‐Mediated Lectin Pathway and Resistin‐MIF‐AA Metabolism Axis Drive Immune Dysfunction in Immune Thrombocytopenia

Advanced Science, Volume 12, Issue 10, March 13, 2025.
Immune thrombocytopenia (ITP) is an autoimmune disorder marked by reduced platelet levels and heightened susceptibility to bleeding resulting from augmented autologous platelet destruction and diminished thrombopoiesis. It is found that the lectin pathway of the complement system, resistin, MIF, and AA metabolism may serve as promising targets for ...
Jin Li, Xiaoqian Wang, Yaoyao Chen, Xianlei Sun, Liyan Fu, Qingxuan Xin, Huilin Zhang, Bo Qin, Nannan Sun, Yingmei Li, Yan Xu, Hui Yang, Dawei Huo, Yong Dong, Shuya Wang, Mengyun Zhao, Quande Lin, Fang Wang, Baohong Yue, Yanxia Gao, Yong Jiang, Rongqun Guo   +21 more
wiley   +1 more source

Two New Kindreds with Complete Factor D Deficiency

European Journal of Immunology, Volume 55, Issue 3, March 2025.
The complement system plays a crucial role in immune defense, and factor D deficiency is a rare immunodeficiency associated with life‐threatening bacterial infections. We report two new cases of complete factor D deficiency, including the first described in a Down syndrome patient, highlighting the need to investigate complement deficiencies in ...
Mathilde Puel, Kenza Rwayane, Paula Vieira Martins, Marwa Chbihi, Frédéric Rieux‐Laucat, Jérémie Rosain, Eric Jeziorski, Bertrand Boisson, Jean‐Laurent Casanova, Véronique Frémeaux‐Bacchi, Carine El Sissy   +10 more
wiley   +1 more source

Methods for detecting, building, and improving tryptophan mannosylation in glycoprotein structures

Protein Science, Volume 34, Issue 2, February 2025.
Abstract Tryptophan mannosylation, the covalent addition of an α‐ᴅ‐mannose sugar to a tryptophan side chain, is a post‐translational modification (PTM) that can affect protein stability, folding, and interactions. Compared to other forms of protein glycosylation, it is relatively uncommon but is affected by conformational anomalies and modeling errors ...
Lou Holland, Phuong Thao Pham, Haroldas Bagdonas, Jordan S. Dialpuri, Lucy C. Schofield, Jon Agirre   +5 more
wiley   +1 more source

Antimicrobial peptides and complement in neonatal hypoxia-ischemia induced brain damage [PDF]

, 2015
Hypoxic-ischemic encephalopathy (HIE) is a clinical condition in the neonate, resulting from oxygen deprivation around the time of birth. HIE affects 1-5/1000 live births worldwide and is associated with the development of neurological deficits ...
Hristova, M, Rocha-Ferreira, E
core   +1 more source

Characterization of the human properdin gene [PDF]

Biochemical Journal, 1992
A cosmid clone containing the complete coding sequence of the human properdin gene has been characterized. The gene is located at one end of the approximately 40 kb cosmid insert and approximately 8.2 kb of the sequence data have been obtained from this region.
Nolan, K. F., Kaluz, S., Higgins, J. M G, Goundis, D., Reid, K. B M   +4 more
openaire   +5 more sources

Hyperfunctional complement C3 promotes C5-dependent atypical hemolytic uremic syndrome in mice [PDF]

, 2019
Atypical hemolytic uremic syndrome (aHUS) is frequently associated in humans with loss-of-function mutations in complement-regulating proteins or gain-of-function mutations in complement-activating proteins.
Smith-Jackson, Kate, Yang, Yi, Denton, Harriet, Pappworth, Isabel Y, Cooke, Katie, Barlow, Paul N, Atkinson, John P, Liszewski, M. K, Pickering, Matthew C, Kavanagh, David, Cook, H. T, Marchbank, Kevin J   +11 more
core   +2 more sources

Complement‐targeted therapeutics: Are we there yet, or just getting started?

European Journal of Immunology, Volume 54, Issue 12, December 2024.
After a hesitant start, the number of available therapeutics that target the human complement system has surged from one to a dozen drugs in less than 20 years. Meanwhile, the clinical arsenal encompasses treatment modalities directed to several targets for the therapy of a steadily growing spectrum of complement‐related disorders. Abstract Therapeutic
Daniel Ricklin
wiley   +1 more source

Urinary Properdin and sC5b-9 Are Independently Associated With Increased Risk for Graft Failure in Renal Transplant Recipients [PDF]

, 2019
The pathophysiology of late kidney-allograft failure remains complex and poorly understood. Activation of filtered or locally produced complement may contribute to the progression of renal failure through tubular C5b-9 formation.
Alyami, Mohammed, Bakker, Stephan J L, Berger, Stefan P, Daha, Mohamed R, Eisenga, Michele F, Lammerts, Rosa G M, Pol, Robert A, Sanders, Jan-Stephan, Seelen, Marc A, van den Born, Jacob   +9 more
core   +1 more source