Properdin oligomers adopt rigid extended conformations supporting function
eLife, 2021 Properdin stabilizes convertases formed upon activation of the complement cascade within the immune system. The biological activity of properdin depends on the oligomerization state, but whether properdin oligomers are rigid and how their structure links
Dennis V Pedersen +6 more
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Regulation of the terminal complement cascade in adipose tissue for control of its volume, cellularity, and fibrosis. [PDF]
Obesity (Silver Spring)Abstract White adipose tissue (WAT) is a reservoir for various pathogens and their products, such as lipopolysaccharides. Therefore, it must be equipped with a defense mechanism connected with the activation of innate immunity. This explains the phenomenon that adipocytes express components of the classical and alternative complement pathways, which ...
Kruglikov IL, Scherer PE.
europepmc +2 more sources
Frontiers in Immunology, 2021 Properdin, a positive regulator of complement alternative pathway, participates in renal ischemia–reperfusion (IR) injury and also acts as a pattern-recognition molecule affecting apoptotic T-cell clearance.
Yuanyuan Wu +10 more
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The Role of Properdin in Killing of Non-Pathogenic Leptospira biflexa
Frontiers in Immunology, 2020 Properdin (P) is a positive regulatory protein that stabilizes the C3 convertase and C5 convertase of the complement alternative pathway (AP). Several studies have suggested that properdin can bind directly to the surface of certain pathogens regardless ...
Adriana Patricia Granados Martinez +7 more
doaj +1 more source
eLife, 2020 Properdin stabilizes the alternative C3 convertase (C3bBb), whereas its role as pattern-recognition molecule mediating complement activation is disputed for decades.
Jie Zhang +8 more
doaj +1 more source
Complement Properdin Determines Disease Activity in MRL/lpr Mice
Medicina, 2020 Background and objects: In systemic lupus erythematosus, circulating immune complexes activate complement and, when trapped in renal capillaries, cause glomerulonephritis.
Hasanain Alaridhee +4 more
doaj +1 more source
Prognostic Value of Complement Properdin in Cancer
Frontiers in Immunology, 2021 The complement system is readily triggered by the presence of damage-associated molecular patterns on the surface of tumor cells. The complement alternative pathway provides rapid amplification of the molecular stress signal, leading to complement ...
Alessandro Mangogna +12 more
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Studies on relationship between serum properdin and cancer I. A modified method for the assay of serum properdin [PDF]
, 1961 1. Properdin assay which is comparatively sensitive and reproducible has been described. The assay may be called a modified method of properdin assay by HUNTER·HILL and McNALL. 2.
Orita, Kunzo
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Studies on relationship between serum properdin and cancer II. Studies on the serum properdin levels of tumor bearing animals and patients with malignant tumors [PDF]
, 1961 1. The properdin levels in sera from mice bearing Ehrlich ascitic carcinoma and from rabbits with Brown-Pearce carcinoma decrease inversely with the increase of the ascites or the tumors. In the incipient period of tumor transplantation, the level rather
Orita, Kunzo
core +1 more source
Age-related macular degeneration associated polymorphism rs10490924 in ARMS2 results in deficiency of a complement activator [PDF]
, 2017 Background Age-related macular degeneration (AMD) is the leading cause of blindness in developed countries. The polymorphism rs10490924 in the ARMS2 gene is highly associated with AMD and linked to an indel mutation (del443ins54), the latter inducing ...
Jacob, Saskia +3 more
core +1 more source