Results 41 to 50 of about 8,202 (220)

Initial properdin binding contributes to alternative pathway activation at the surface of viable and necrotic cells

European Journal of Immunology, 2022
Properdin, the only known positive regulator of the complement system, stabilizes the C3 convertase, thereby increasing its half‐life. In contrast to most other complement factors, properdin is mainly produced extrahepatically by myeloid cells.
M. V. van Essen, N. Schlagwein, E. M. van den Hoven, D. V. van Gijlswijk-Janssen, R. Lubbers, R. M. van den Bos, J. van den Born, J. Ruben, L. Trouw, C. van Kooten   +9 more
semanticscholar   +1 more source

The Role of Properdin in C5 Convertase Activity and C5b-9 Formation in the Complement Alternative Pathway

Journal of Immunology, 2021
Key Points Properdin is required for AP-mediated C5 convertase activity and C5b-9 formation. Properdin induces a switch in convertase specificity toward C5. Properdin has a crucial role in AP activation and total complement activation.
Marloes A. H. M. Michels, Rianne J. F. Maas, T. van der Velden, N. C. van de Kar, L. van den Heuvel, E. Volokhina   +5 more
semanticscholar   +1 more source

CSF proteomics reveals changes in myelin and synaptic biology after Spectris treatment. [PDF]

Alzheimers Dement (N Y)
Abstract INTRODUCTION Brain steady‐state gamma oscillations evoked using a non‐invasive medical device (Spectris) have shown potential clinical benefits in patients with mild–moderate Alzheimer's disease (AD), including reduced functional and cognitive decline, reduced brain volume and myelin loss, and increased brain functional connectivity.
Hajós M, Pandey K, Singer AC, Duong D, Bitarafan S, Shpokayte M, Malchano Z, Kern R, Lah JJ, Levey AI, Seyfried NT.   +10 more
europepmc   +2 more sources

Properdin and Factor H: Opposing players on the alternative complement pathway see-saw

Frontiers in Immunology, 2013
Properdin and factor H are two key regulatory proteins having opposite functions in the alternative complement pathway. Properdin up-regulates the alternative pathway by stabilising the C3bBb complex, whereas factor H down-regulates the pathway by ...
Lubna eKouser, Munirah eAbdul-Aziz, Munirah eAbdul-Aziz, Annapurna eNayak, Cordula M Stover, Robert B Sim, Robert B Sim, Uday eKishore   +7 more
doaj   +1 more source

A novel antibody against human properdin inhibits the alternative complement system and specifically detects properdin from blood samples.

PLoS ONE, 2014
The complement system is an essential part of the innate immune system by acting as a first line of defense which is stabilized by properdin, the sole known positive regulator of the alternative complement pathway. Dysregulation of complement can promote
Diana Pauly, Benedikt M Nagel, Jörg Reinders, Tobias Killian, Matthias Wulf, Susanne Ackermann, Boris Ehrenstein, Peter F Zipfel, Christine Skerka, Bernhard H F Weber   +9 more
doaj   +1 more source

Local release of properdin in the cellular microenvironment: Role in pattern recognition and amplification of the alternative pathway of complement

Frontiers in Immunology, 2013
Properdin, the only positive regulatory protein of the complement system, acts as both a stabilizer of the alternative pathway convertases and as a selective pattern recognition molecule of certain microorganisms and host cells (i.e.
Claudio eCortes, Claudio eCortes, Jennifer A Ohtola, Gurpanna eSaggu, Viviana Patricia Ferreira   +4 more
doaj   +1 more source

Properdin

Definitions, 2020
Properdin (469 aa, ~51 kDa) is encoded by the human CFP gene. This protein plays a role in the stabilization of complement convertases of the alternative pathway.

semanticscholar   +1 more source

The Properdin System in Mice.

Experimental Biology and Medicine, 1960
SummaryInjection of complement (guinea pig serum) into the laboratory albino mouse failed to alter capacity of these animals to withstand parenterally induced bacterial infection with K. pneumoniae or S. typhimurium. Addition of complement to mouse serum failed to induce bactericidal activity in vitro.
Fred Miya, Stanley Marcus, Eugene H. Perkins   +2 more
openaire   +3 more sources

Properdin oligomers adopt rigid extended conformations supporting function

bioRxiv, 2020
Properdin stabilizes convertases formed upon activation of the complement cascade within the immune system. The biological activity of properdin depends on the oligomerization state, but whether properdin oligomers are rigid and how their structure links
D. Pedersen, M. N. Pedersen, Sofia M. M. Mazarakis, Yong Wang, K. Lindorff-Larsen, L. Arleth, G. Andersen   +6 more
semanticscholar   +1 more source

Complement Initiation Varies by Sex in Intestinal Ischemia Reperfusion Injury

Frontiers in Immunology, 2021
Intestinal ischemia reperfusion (IR)-induced tissue injury represents an acute inflammatory response with significant morbidity and mortality. The mechanism of IR-induced injury is not fully elucidated, but recent studies suggest a critical role for ...
Miaomiao Wu, Miaomiao Wu, Jennifer M. Rowe, Sherry D. Fleming   +3 more
doaj   +1 more source