Results 41 to 50 of about 10,182 (218)
Properdin oligomers adopt rigid extended conformations supporting function [PDF]
bioRxiv, 2020 Properdin stabilizes convertases formed upon activation of the complement cascade within the immune system. The biological activity of properdin depends on the oligomerization state, but whether properdin oligomers are rigid and how their structure links
Dennis Pedersen +6 more
openalex +2 more sources
Endothelial Glycocalyx: The Missing Link Between Angiogenic Imbalance in Preeclampsia and Systemic Inflammation in HELLP Syndrome. [PDF]
Compr PhysiolEndothelial glycocalyx may be the missing link between angiogenic factors, inflammatory regulation, and endothelial maternal dysfunction in early‐onset preeclampsia and HELLP syndrome. ABSTRACT The pathophysiology of preeclampsia and HELLP syndrome relies on systemic vascular endothelial dysfunction, resulting from angiogenic imbalance due to abnormal ...
Atallah A +4 more
europepmc +2 more sources
Immunological Reviews, 2022 Structures of alternative pathway proteins have offered a comprehensive structural basis for understanding the molecular mechanisms governing activation and regulation of the amplification pathway of the complement cascade.
D. Pedersen +2 more
semanticscholar +1 more source
Properdin oligomers adopt rigid extended conformations supporting function
eLife, 2021 Properdin stabilizes convertases formed upon activation of the complement cascade within the immune system. The biological activity of properdin depends on the oligomerization state, but whether properdin oligomers are rigid and how their structure links
Dennis V Pedersen +6 more
doaj +1 more source
European Journal of Immunology, 2022 Properdin, the only known positive regulator of the complement system, stabilizes the C3 convertase, thereby increasing its half‐life. In contrast to most other complement factors, properdin is mainly produced extrahepatically by myeloid cells.
Mieke F. van Essen +9 more
semanticscholar +1 more source
Research and Practice in Thrombosis and Haemostasis, 2022 Evidence of crosstalk between the complement and coagulation cascades exists, and dysregulation of either pathway can lead to serious thromboinflammatory events. Both the intrinsic pathway of coagulation and the alternative pathway of complement interact
S. Heal +6 more
semanticscholar +1 more source
Proteomic analysis of plasma proteins during fentanyl withdrawal in ovariectomized female rats with and without estradiol. [PDF]
J NeuroendocrinolAbstract Evidence from both clinical and preclinical studies indicates that females experience a faster progression to drug addiction and more severe addiction‐related health effects compared with males. Estradiol (E2) plays a critical role in these sex differences.
Sinclair P +4 more
europepmc +2 more sources
Journal of Immunology, 2021 Key Points Properdin is required for AP-mediated C5 convertase activity and C5b-9 formation. Properdin induces a switch in convertase specificity toward C5. Properdin has a crucial role in AP activation and total complement activation.
Marloes A. H. M. Michels +5 more
semanticscholar +1 more source
Regulation of the terminal complement cascade in adipose tissue for control of its volume, cellularity, and fibrosis. [PDF]
Obesity (Silver Spring)Abstract White adipose tissue (WAT) is a reservoir for various pathogens and their products, such as lipopolysaccharides. Therefore, it must be equipped with a defense mechanism connected with the activation of innate immunity. This explains the phenomenon that adipocytes express components of the classical and alternative complement pathways, which ...
Kruglikov IL, Scherer PE.
europepmc +2 more sources