Results 41 to 50 of about 8,235 (150)
Glia, Volume 72, Issue 12, Page 2295-2312, December 2024.Main Points Hyposialylation in Gne+/‐ mice induced loss of retinal rod bipolar cells. Hyposialylation triggered complement, inflammation and apoptosis transcriptome pathways in the retina. Crossing Gne+/‐ with C3‐deficient mice prevented the retinal changes.
German Cuevas‐Rios +6 more
wiley +1 more source
The Journal of Dermatology, Volume 51, Issue 12, Page 1665-1668, December 2024.Abstract Pemphigus vulgaris (PV) is a severe autoimmune bullous dermatosis that is characterized by autoantibodies against epidermal adhesion proteins causing painful mucosal and skin blistering. Standard treatments for PV include corticosteroids, steroid‐sparing immunosuppressants, or intravenous monoclonal anti–CD20‐antibody therapy.
Nadine Wiedenmayer +4 more
wiley +1 more source
The complement system: A key player in the host response to infections
European Journal of Immunology, Volume 54, Issue 11, November 2024.Duality of the complement system during infection: An adequate immune defense clears the infection and restores tissue resilience, whereas a maladaptive response due to complement hyperactivation results in hyperinflammation and tissue injury, as seen in sepsis and pneumonia.
Archana Jayaraman +2 more
wiley +1 more source
MedComm, Volume 5, Issue 11, November 2024.Understanding the alterations in complement and coagulation systems could aid in the creation of novel therapeutic approaches to tackle the dysfunction of complement and coagulation in diseases. The unacceptably high mortality rate of sepsis has prompted further research into the molecular pathogenesis of sepsis and therapeutic interventions.
Honghong Jiang +12 more
wiley +1 more source
The Properdin System: Composition and Function [PDF]
Vox Sanguinis, 1978 Abstract.This article summarizes the physicochemical data on the factors which compose the properdin system in guinea pig and man. The following other topics are discussed: (1) Activation of the properdin system; (2) Formation of the initiating and amplification C3 convertases; (3) Formation of the C5 convertase, and (4) Regulatory control mechanisms ...
openaire +3 more sources
Muscle &Nerve, Volume 70, Issue 4, Page 851-861, October 2024.Plasma C3a and sC5b‐9 are promising blood biomarkers with very high sensitivity and specificity for complement activation in myasthenia gravis (MG). Further, the in vitro study supported membrane attack complex deposition after applying AChR+ MG sera on human muscle cells.
Yu‐Fang Huang +4 more
wiley +1 more source
European Journal of Immunology, Volume 54, Issue 9, September 2024.Factor D (FD) and MASP3 are two proteases that are critical for alternative pathway complement activation and represent attractive therapeutic targets for complement‐mediated human diseases. Abstract The alternative pathway (AP) plays a major role in many complement‐mediated human diseases.
Eshagh Mohammadyari +3 more
wiley +1 more source
Innate immunity and neuroinflammation [PDF]
, 2013 Copyright © 2013 Abhishek Shastri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly ...
Bonifati, DM, Kishore, U, Shastri, A
core +3 more sources
A molecular concept of the properdin pathway. [PDF]
Proceedings of the National Academy of Sciences, 1976 The sequential events of the properdin system were analyzed. Properdin-depleted serum allows the formation of a Factor B- and D-dependent C3 convertase. This enzyme, called the properdin-receptor-forming enzyme, was shown to utilize a novel serum component, the initiating factor.
Rudolf G. Medicus +3 more
openaire +3 more sources
Crepuscular rays — The bright side of complement after tissue injury
European Journal of Immunology, Volume 54, Issue 9, September 2024.Traumatic injuries elicit an activation of the complement system. Due to its overwhelming nature, it's often described as harmful, while its protective effects are overlooked. This review focuses on and summarizes the advantageous aspects of complement shining as “sunbeams” through the otherwise negative‐afflicted “clouds” (i.e.
Marco Mannes +4 more
wiley +1 more source