Results 41 to 50 of about 6,114 (163)
Activation of the Lectin Pathway Drives Persistent Complement Dysregulation in Long COVID
Immunology, EarlyView.The complement cascade, a series of blood proteins that assists in the recognition and neutralisation of pathogens, either independently or in conjunction with antibodies, is persistently activated in patients with long COVID. We found that blood plasma samples from patients with long COVID contained elevated concentrations of the mannan‐binding lectin‐
Samuel B. K. Keat +14 more
wiley +1 more source
Frontiers in Immunology, 2018 Mycobacterium tuberculosis can proficiently enter macrophages and diminish complement activation on its cell surface. Within macrophages, the mycobacterium can suppress macrophage apoptosis and survive within the intracellular environment. Previously, we
Maha Ahmed Al-Mozaini +14 more
doaj +1 more source
Complement Dysregulation in Obese Versus Nonobese Polycystic Ovary Syndrome Patients
Cells, 2023 Introduction: Upregulation of complement system factors are reported to be increased in polycystic ovary syndrome (PCOS) and may be due to obesity and insulin resistance rather than inherently due to PCOS.
Alexandra E. Butler +3 more
doaj +1 more source
Complement alternative pathway activation in human nonalcoholic steatohepatitis. [PDF]
PLoS ONE, 2014 The innate immune system plays a major role in the pathogenesis of nonalcoholic steatohepatitis (NASH). Recently we reported complement activation in human NASH.
Filip M Segers +9 more
doaj +1 more source
The FASEB Journal, Volume 40, Issue 4, 28 February 2026.Sex and the developmental environment shape molecular networks underlying bronchial responsiveness in mice. A methacholine challenge was performed on 13‐week‐old isogenic male and female offspring (+/− developmental particulate matter exposure) to show that males had significantly higher bronchial responsiveness (red arrows) than females.
Razia Zakarya +8 more
wiley +1 more source
Properdin: A Novel Target for Neuroprotection in Neonatal Hypoxic-Ischemic Brain Injury
Frontiers in Immunology, 2019 Background: Hypoxic-ischemic (HI) encephalopathy is a major cause of neonatal mortality and morbidity, with a global incidence of 3 per 1,000 live births.
Claudia Sisa +5 more
doaj +1 more source
Meningococcal Serogroup Y Meningitis Reveals Inborn Factor B Deficiency
European Journal of Immunology, Volume 56, Issue 2, February 2026.We report a novel case of complete complement Factor B deficiency revealed by invasive meningococcal disease. Using combined functional and genetic analyses, we demonstrate that loss of Factor B abolishes alternative pathway activity despite detectable protein levels. These findings provide a mechanistic framework relevant to complement diagnostics and
Camille Bougeard +9 more
wiley +1 more source
Exploring urine:serum fractional excretion ratios as potential biomarkers for lupus nephritis
Frontiers in Immunology, 2022 ObjectivesThe goal of this exploratory study is to determine if urine:serum fractional excretion ratios can outperform the corresponding urinary biomarker proteins in identifying active renal disease in systemic lupus erythematosus (SLE).MethodsThirty ...
Samar A. Soliman +6 more
doaj +1 more source
Antioxidants, 2020 The retinal pigment epithelium (RPE) maintains visual function and preserves structural integrity of the retina. Chronic dysfunction of the RPE is associated with retinal degeneration, including age-related macular degeneration (AMD).
Nicole Schäfer +6 more
doaj +1 more source
Alzheimer's &Dementia, Volume 21, Issue S2, December 2025.Abstract Background While evidence suggests complement system involvement in Alzheimer's disease (AD), dementia with Lewy bodies (DLB), and Parkinson's disease (PD), its association with disease biomarkers remains unclear. We investigated the relationship of complement factors with amyloid, tau, NfL, and α‐synuclein in CSF in AD, DLB, PD, and controls.
Marianna Rizzo +29 more
wiley +1 more source