Results 51 to 60 of about 10,182 (218)

Variability and action mechanism of a family of anticomplement proteins in Ixodes ricinus. [PDF]

PLoS ONE, 2008
BACKGROUND: Ticks are blood feeding arachnids that characteristically take a long blood meal. They must therefore counteract host defence mechanisms such as hemostasis, inflammation and the immune response.
Bernard Couvreur, Jérôme Beaufays, Cédric Charon, Kathia Lahaye, François Gensale, Valérie Denis, Benoît Charloteaux, Yves Decrem, Pierre-Paul Prévôt, Michel Brossard, Luc Vanhamme, Edmond Godfroid   +11 more
doaj   +1 more source

The alternative pathway of complement activation may be involved in the renal damage of human anti-glomerular basement membrane disease. [PDF]

PLoS ONE, 2014
Linear deposition of IgG and complement 3 (C3) along glomerular basement membrane (GBM) is generally revealed in the kidneys of human anti-GBM disease. Our recent studies demonstrated the pathogenic role of complement activation in renal damage of this ...
Rui Ma, Zhao Cui, Shui-Yi Hu, Xiao-Yu Jia, Rui Yang, Xin Zheng, Jie Ao, Gang Liu, Yun-Hua Liao, Ming-Hui Zhao   +9 more
doaj   +1 more source

Complement Initiation Varies by Sex in Intestinal Ischemia Reperfusion Injury

Frontiers in Immunology, 2021
Intestinal ischemia reperfusion (IR)-induced tissue injury represents an acute inflammatory response with significant morbidity and mortality. The mechanism of IR-induced injury is not fully elucidated, but recent studies suggest a critical role for ...
Miaomiao Wu, Miaomiao Wu, Jennifer M. Rowe, Sherry D. Fleming   +3 more
doaj   +1 more source

Complement Dysregulation in Obese Versus Nonobese Polycystic Ovary Syndrome Patients

Cells, 2023
Introduction: Upregulation of complement system factors are reported to be increased in polycystic ovary syndrome (PCOS) and may be due to obesity and insulin resistance rather than inherently due to PCOS.
Alexandra E. Butler, Abu Saleh Md Moin, Thozhukat Sathyapalan, Stephen L. Atkin   +3 more
doaj   +1 more source

Activation of the Lectin Pathway Drives Persistent Complement Dysregulation in Long COVID

Immunology, EarlyView.
The complement cascade, a series of blood proteins that assists in the recognition and neutralisation of pathogens, either independently or in conjunction with antibodies, is persistently activated in patients with long COVID. We found that blood plasma samples from patients with long COVID contained elevated concentrations of the mannan‐binding lectin‐
Samuel B. K. Keat, Priyanka Khatri, Youssif M. Ali, Chanuka H. Arachchilage, Gregory Demopulos, Kirsten Baillie, Kelly L. Miners, Kristin Ladell, Samantha A. Jones, Helen E. Davies, David A. Price, Wioleta M. Zelek, B. Paul Morgan, Wilhelm J. Schwaeble, Nicholas J. Lynch   +14 more
wiley   +1 more source

Complement alternative pathway activation in human nonalcoholic steatohepatitis. [PDF]

PLoS ONE, 2014
The innate immune system plays a major role in the pathogenesis of nonalcoholic steatohepatitis (NASH). Recently we reported complement activation in human NASH.
Filip M Segers, Froukje J Verdam, Charlotte de Jonge, Bas Boonen, Ann Driessen, Ronit Shiri-Sverdlov, Nicole D Bouvy, Jan Willem M Greve, Wim A Buurman, Sander S Rensen   +9 more
doaj   +1 more source

Associations between CSF complement factors and biomarkers of amyloid, tau, neurofilament light chain, and α‐synuclein in AD, DLB, and PD

Alzheimer's &Dementia, Volume 21, Issue S2, December 2025.
Abstract Background While evidence suggests complement system involvement in Alzheimer's disease (AD), dementia with Lewy bodies (DLB), and Parkinson's disease (PD), its association with disease biomarkers remains unclear. We investigated the relationship of complement factors with amyloid, tau, NfL, and α‐synuclein in CSF in AD, DLB, PD, and controls.
Marianna Rizzo, Charlotte E. Teunissen, Frederic Brosseron, Sandra Kuhs, Gwendlyn Kollmorgen, Henrik Zetterberg, Kaj Blennow, Rejko Krüger, Sara B. Gomes Fernandes, Dag Aarsland, Olga Borejko, Davit Chokoshvili, Wiesje M. van der Flier, Afina W. Lemstra, Betty M. Tijms, Gabor C Petzold, Annika Spottke, Giovanni B. Frisoni, Kathrin Brockmann, Thomas Gasser, Tormod Fladby, Marianne Wettergreen, Frank Jessen, Emrah Düzel, Günter U Höglinger, Claire Chevalier, Rajaraman Krishnan, Pieter Jelle Visser, Stephanie J. B. Vos, the IMI EPND consortium   +29 more
wiley   +1 more source

Cellular Communication Networks Mediated by Microglia in Ischemic Stroke

CNS Neuroscience &Therapeutics, Volume 31, Issue 12, December 2025.
After ischemic stroke, microglia serve as central regulators within the neuroimmune network, engaging in dynamic crosstalk with neurons, astrocytes, vascular endothelial cells, and peripheral immune cells. By releasing cytokines, chemokines, extracellular vesicles, and transmitting mechanical signals, activated microglia coordinate inflammatory ...
Feiyu Ma, Yi Bai, Na Li, Xiangyu Cai, Ruicong Xu, Xiang Cao   +5 more
wiley   +1 more source

Exploring urine:serum fractional excretion ratios as potential biomarkers for lupus nephritis

Frontiers in Immunology, 2022
ObjectivesThe goal of this exploratory study is to determine if urine:serum fractional excretion ratios can outperform the corresponding urinary biomarker proteins in identifying active renal disease in systemic lupus erythematosus (SLE).MethodsThirty ...
Samar A. Soliman, Samar A. Soliman, Samantha Stanley, Kamala Vanarsa, Faten Ismail, Chi Chiu Mok, Chandra Mohan   +6 more
doaj   +1 more source

Invasive Meningococcal Disease in a Patient With Complement 7 Deficiency

Journal of General and Family Medicine, Volume 26, Issue 6, Page 646-649, November 2025.
ABSTRACT Neisseria meningitidis can cause invasive meningococcal disease (IMD). Individuals with primary complement deficiencies are at a higher risk of developing IMD. However, cases of IMD associated with complement deficiency have rarely been reported in Japan.
Hiroaki Nishioka, Kazuki Maegawa, Shigeo Hara   +2 more
wiley   +1 more source