Results 51 to 60 of about 8,202 (220)
The alternative pathway of complement activation may be involved in the renal damage of human anti-glomerular basement membrane disease. [PDF]
PLoS ONE, 2014 Linear deposition of IgG and complement 3 (C3) along glomerular basement membrane (GBM) is generally revealed in the kidneys of human anti-GBM disease. Our recent studies demonstrated the pathogenic role of complement activation in renal damage of this ...
Rui Ma +9 more
doaj +1 more source
Variability and action mechanism of a family of anticomplement proteins in Ixodes ricinus. [PDF]
PLoS ONE, 2008 BACKGROUND: Ticks are blood feeding arachnids that characteristically take a long blood meal. They must therefore counteract host defence mechanisms such as hemostasis, inflammation and the immune response.
Bernard Couvreur +11 more
doaj +1 more source
Clinical and Experimental Immunology, 2020 Properdin is the only positive regulator of the complement system. In this study, we characterize the prevalence, functional consequences and disease associations of autoantibodies against properdin in a cohort of patients with autoimmune disease ...
M. Radanova +6 more
semanticscholar +1 more source
Journal of Neuroendocrinology, EarlyView.Abstract Evidence from both clinical and preclinical studies indicates that females experience a faster progression to drug addiction and more severe addiction‐related health effects compared with males. Estradiol (E2) plays a critical role in these sex differences.
Patricia Sinclair +4 more
wiley +1 more source
Complement alternative pathway activation in human nonalcoholic steatohepatitis. [PDF]
PLoS ONE, 2014 The innate immune system plays a major role in the pathogenesis of nonalcoholic steatohepatitis (NASH). Recently we reported complement activation in human NASH.
Filip M Segers +9 more
doaj +1 more source
Acta Obstetricia et Gynecologica Scandinavica, Volume 104, Issue 5, Page 829-838, May 2025.Preeclampsia fetuses show an altered profile of endothelial damage and complement biomarkers, like increased adhesion molecules, prothrombotic state, oxidative stress, and reduced complement membrane attack complex deposition on endothelial cells. Abstract Introduction Our objective was to evaluate the endothelial function profile and complement system
Alex Ramos +17 more
wiley +1 more source
Exploring urine:serum fractional excretion ratios as potential biomarkers for lupus nephritis
Frontiers in Immunology, 2022 ObjectivesThe goal of this exploratory study is to determine if urine:serum fractional excretion ratios can outperform the corresponding urinary biomarker proteins in identifying active renal disease in systemic lupus erythematosus (SLE).MethodsThirty ...
Samar A. Soliman +6 more
doaj +1 more source
Zeitschrift für Naturforschung B, 1966 Mit einer neuen, mikrochemischen Analysenmethode wurden Untersuchungen über den Bildungsort des Properdins, die Beeinflussung des Wachstums von Impftumoren durch das Properdinsystem und die Wirkung von Cancerostatica wie Actinomycin C1, Mercaleukin, Colchicin, Honvan und Cyclophosphamid sowie Prednison und Desoxycorticosteronacetat auf die humorale ...
openaire +3 more sources
Advanced Science, Volume 12, Issue 10, March 13, 2025.Immune thrombocytopenia (ITP) is an autoimmune disorder marked by reduced platelet levels and heightened susceptibility to bleeding resulting from augmented autologous platelet destruction and diminished thrombopoiesis. It is found that the lectin pathway of the complement system, resistin, MIF, and AA metabolism may serve as promising targets for ...
Jin Li +21 more
wiley +1 more source