Results 51 to 60 of about 11,905 (245)

Complement Properdin Regulates the Metabolo-Inflammatory Response to a High Fat Diet

Medicina, 2020
Background and objectives: Overnutrition leads to a metabolic and inflammatory response that includes the activation of Complement. Properdin is the only amplifier of complement activation and increases the provision of complement activation products ...
Rόisín C. Thomas, Ramiar Kheder, Hasanain Alaridhee, Naomi Martin, Cordula M. Stover   +4 more
doaj   +1 more source

The alternative pathway of complement activation may be involved in the renal damage of human anti-glomerular basement membrane disease. [PDF]

PLoS ONE, 2014
Linear deposition of IgG and complement 3 (C3) along glomerular basement membrane (GBM) is generally revealed in the kidneys of human anti-GBM disease. Our recent studies demonstrated the pathogenic role of complement activation in renal damage of this ...
Rui Ma, Zhao Cui, Shui-Yi Hu, Xiao-Yu Jia, Rui Yang, Xin Zheng, Jie Ao, Gang Liu, Yun-Hua Liao, Ming-Hui Zhao   +9 more
doaj   +1 more source

Properdin has an ascendancy over factor H regulation in complement-mediated renal tubular damage [PDF]

, 2014
BACKGROUND: Urinary (U)-complement components have been detected in patients with proteinuric renal diseases, and complement activation via the alternative pathway (AP) is believed to play a role in renal tubular damage.
Atsuko Hisada, Daisuke Honda, Hiroyuki Inoshita, Hiyori Suzuki, Isao Ohsawa, Mamiko Shimamoto, Nobuyuki Sato, Satoshi Horikoshi, Seiji Nagamachi, Yasuhiko Tomino, Yoshio Shimizu   +10 more
core   +1 more source

The Properdin System in Mice.

Experimental Biology and Medicine, 1960
SummaryInjection of complement (guinea pig serum) into the laboratory albino mouse failed to alter capacity of these animals to withstand parenterally induced bacterial infection with K. pneumoniae or S. typhimurium. Addition of complement to mouse serum failed to induce bactericidal activity in vitro.
Fred Miya, Stanley Marcus, Eugene H. Perkins   +2 more
openaire   +3 more sources

Variability and action mechanism of a family of anticomplement proteins in Ixodes ricinus. [PDF]

PLoS ONE, 2008
BACKGROUND: Ticks are blood feeding arachnids that characteristically take a long blood meal. They must therefore counteract host defence mechanisms such as hemostasis, inflammation and the immune response.
Bernard Couvreur, Jérôme Beaufays, Cédric Charon, Kathia Lahaye, François Gensale, Valérie Denis, Benoît Charloteaux, Yves Decrem, Pierre-Paul Prévôt, Michel Brossard, Luc Vanhamme, Edmond Godfroid   +11 more
doaj   +1 more source

Autoantibodies to complement components in C3 glomerulopathy and atypical hemolytic uremic syndrome. [PDF]

, 2014
The alternative pathway of complement is implicated in the pathogenesis of several renal diseases, such as atypical hemolytic uremic syndrome, dense deposit disease and other forms of C3 glomerulopathy.
Józsi, Mihály, Lopez-Trascasa, M., Nozal, P., Prohászka, Zoltán, Reuter, S., Sanchez-Corral, P., Uzonyi, Barbara   +6 more
core   +1 more source

Automatic case acquisition from texts for process-oriented case-based reasoning [PDF]

, 2012
This paper introduces a method for the automatic acquisition of a rich case representation from free text for process-oriented case-based reasoning. Case engineering is among the most complicated and costly tasks in implementing a case-based reasoning ...
Ber, Florence Le, Dufour-Lussier, Valmi, Lieber, Jean, Nauer, Emmanuel   +3 more
core   +4 more sources

Urinary Properdin and sC5b-9 Are Independently Associated With Increased Risk for Graft Failure in Renal Transplant Recipients

Frontiers in Immunology, 2019
The pathophysiology of late kidney-allograft failure remains complex and poorly understood. Activation of filtered or locally produced complement may contribute to the progression of renal failure through tubular C5b-9 formation.
Rosa G. M. Lammerts, Michele F. Eisenga, Mohammed Alyami, Mohamed R. Daha, Marc A. Seelen, Robert A. Pol, Jacob van den Born, Jan-Stephan Sanders, Stephan J. L. Bakker, Stefan P. Berger   +9 more
doaj   +1 more source

Immunologic aspects of the nephrotic syndrome [PDF]

, 1973
The nephrotic syndrome is a clinical entity characterized by proteinuria, hypoalbuminemia, edema and hyperlipidemia. All the features of this syndrome are ultimately related to increased permeability of the glomerular capillary to protein.
Michael, Alfred F., McLean, Robert H., Roy, L.Paul, Westberg, N.Gunnar, Hoyer, John R., Fish, Alfred J., Vernier, Robert L.   +6 more
core   +4 more sources

Human Properdin Modulates Macrophage: Mycobacterium bovis BCG Interaction via Thrombospondin Repeats 4 and 5

Frontiers in Immunology, 2018
Mycobacterium tuberculosis can proficiently enter macrophages and diminish complement activation on its cell surface. Within macrophages, the mycobacterium can suppress macrophage apoptosis and survive within the intracellular environment. Previously, we
Maha Ahmed Al-Mozaini, Maha Ahmed Al-Mozaini, Anthony G. Tsolaki, Munirah Abdul-Aziz, Munirah Abdul-Aziz, Suhair M. Abozaid, Suhair M. Abozaid, Mohammed N. Al-Ahdal, Ansar A. Pathan, Valarmathy Murugaiah, Evgeny M. Makarov, Anuvinder Kaur, Robert B. Sim, Uday Kishore, Lubna Kouser   +14 more
doaj   +1 more source