Results 51 to 60 of about 6,114 (163)

Cellular Communication Networks Mediated by Microglia in Ischemic Stroke

CNS Neuroscience &Therapeutics, Volume 31, Issue 12, December 2025.
After ischemic stroke, microglia serve as central regulators within the neuroimmune network, engaging in dynamic crosstalk with neurons, astrocytes, vascular endothelial cells, and peripheral immune cells. By releasing cytokines, chemokines, extracellular vesicles, and transmitting mechanical signals, activated microglia coordinate inflammatory ...
Feiyu Ma, Yi Bai, Na Li, Xiangyu Cai, Ruicong Xu, Xiang Cao   +5 more
wiley   +1 more source

Protective role for properdin in progression of experimental murine atherosclerosis.

PLoS ONE, 2014
Genetic, dietary and immune factors contribute to the pathogenesis of atherosclerosis in humans and mice. Complement activation is an integral part of the innate immune defence but also shapes cellular responses and influences directly triglyceride ...
Tanja Steiner, Lorenza Francescut, Simon Byrne, Timothy Hughes, Archana Jayanthi, Irina Guschina, John Harwood, Katherine Cianflone, Cordula Stover, Sheila Francis   +9 more
doaj   +1 more source

Invasive Meningococcal Disease in a Patient With Complement 7 Deficiency

Journal of General and Family Medicine, Volume 26, Issue 6, Page 646-649, November 2025.
ABSTRACT Neisseria meningitidis can cause invasive meningococcal disease (IMD). Individuals with primary complement deficiencies are at a higher risk of developing IMD. However, cases of IMD associated with complement deficiency have rarely been reported in Japan.
Hiroaki Nishioka, Kazuki Maegawa, Shigeo Hara   +2 more
wiley   +1 more source

Complement activation in Hidradenitis suppurativa: Covert low-grade inflammation or innocent bystander?

Frontiers in Immunology, 2022
Hidradenitis suppurativa (HS) is a chronic auto-inflammatory skin disease with a complex and multifactorial pathogenesis involving both the innate and adaptive immune system.
K. R. van Straalen, K. Dudink, P. Aarts, H. H. van der Zee, T. P. P. van den Bosch, J. Giang, E. P. Prens, E. P. Prens, J. Damman   +8 more
doaj   +1 more source

Immunoglobulin A Nephropathy: Molecular Pathogenesis and Targeted Therapy

MedComm, Volume 6, Issue 9, September 2025.
The future of IgAN treatment likely involves combining several therapies to target multiple disease mechanisms simultaneously. Clinical trials are ongoing to evaluate the efficacy and safety of various combinations. As our understanding of IgAN pathogenesis evolves, more targeted and personalized treatment strategies are expected to emerge.
Xu‐Jie Zhou
wiley   +1 more source

Unraveling the Molecular Mechanisms Underlying Complement Dysregulation by Nephritic Factors in C3G and IC-MPGN

Frontiers in Immunology, 2018
Membranoproliferative glomerulonephritis (MPGN) was recently classified as C3 glomerulopathies (C3G), and immune-complex (IC) mediated MPGN. Dysregulation of the complement alternative pathway, driven by acquired and/or genetic defects, plays a ...
Roberta Donadelli, Patrizia Pulieri, Rossella Piras, Paraskevas Iatropoulos, Elisabetta Valoti, Ariela Benigni, Giuseppe Remuzzi, Giuseppe Remuzzi, Giuseppe Remuzzi, Marina Noris   +9 more
doaj   +1 more source

Low molecular weight polysialic acid binds to properdin and reduces the activity of the alternative complement pathway

Scientific Reports, 2022
Sialic acids as the terminal caps of the cellular glycocalyx play an essential role in self-recognition and were shown to modulate complement processes via interaction between α2,3-linked sialic acids and complement factor H. Previously, it was suggested
Anahita Shahraz, Yuchen Lin, Joshua Mbroh, Jonas Winkler, Huan Liao, Marie Lackmann, Annemarie Bungartz, Peter F. Zipfel, Christine Skerka, Harald Neumann   +9 more
doaj   +1 more source

Short‐Term Severe Energy Restriction Promotes Molecular Health and Reverses Aging Signatures in Adults With Prediabetes in the PREVIEW Study

Aging Cell, Volume 24, Issue 8, August 2025.
Severe short‐term energy restriction in adults with prediabetes led to a significant reduction in circulating proteins linked to inflammation, senescence, and protein turnover. These changes, partly mediated by extracellular vesicles, suggest systemic dietary‐induced benefits beyond glycemic control, including improved aging biomarkers.
Maria Lastra Cagigas, Andrius Masedunskas, Yao Lin, Samantha J. Emery‐Corbin, Jumana M. Yousef, Laura F. Dagley, Sam Olechnowicz, Rory Bowden, Rachael Hayward, Gary Low, Roslyn Muirhead, Jennie Brand‐Miller, Mikael Fogeltholm, Anne Raben, Marco Demaria, Stephen J. Fuller, Luigi Fontana   +16 more
wiley   +1 more source

Hybrid mass spectrometry approaches in glycoprotein analysis and their usage in scoring biosimilarity

Nature Communications, 2016
Many biopharmaceuticals exhibit mixed heterogeneity in their post-translational modifications (PTMs) that are essential for their function. Here the authors use a combination of mass spectrometry techniques to analyse human erythropoietin (EPO) and ...
Yang Yang, Fan Liu, Vojtech Franc, Liem Andhyk Halim, Huub Schellekens, Albert J. R. Heck   +5 more
doaj   +1 more source

Regulation of the terminal complement cascade in adipose tissue for control of its volume, cellularity, and fibrosis

Obesity, Volume 33, Issue 5, Page 839-850, May 2025.
Abstract White adipose tissue (WAT) is a reservoir for various pathogens and their products, such as lipopolysaccharides. Therefore, it must be equipped with a defense mechanism connected with the activation of innate immunity. This explains the phenomenon that adipocytes express components of the classical and alternative complement pathways, which ...
Ilja L. Kruglikov, Philipp E. Scherer
wiley   +1 more source