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CNS/PNS proteoglycans functionalize neuronal and astrocyte niche microenvironments optimizing cellular activity by preserving membrane polarization dynamics, ionic microenvironments, ion fluxes, neuronal activation, and network neurotransductive capacity

Journal of Neuroscience Research, Volume 102, Issue 7, July 2024.
Proteoglycans are important multifunctional components of the central and peripheral nervous systems and represent a diverse group of specialized proteins that stabilize and functionalize these tissues. Abstract Central and peripheral nervous system (CNS/PNS) proteoglycans (PGs) have diverse functional roles, this study examined how these control ...
James Melrose
wiley +1 more source

Complement inhibition in paroxysmal nocturnal hemoglobinuria: From biology to therapy

International Journal of Laboratory Hematology, Volume 46, Issue S1, Page 43-54, May 2024.
Abstract Complement inhibitors are the mainstay of paroxysmal nocturnal hemoglobinuria (PNH) treatment. The anti‐C5 monoclonal antibody eculizumab was the first treatment to improve hemolysis, thrombotic risk, and survival in PNH although at the price of a life‐long intravenous fortnightly drug.
Francesco Versino, Bruno Fattizzo
wiley +1 more source

Hematological changes in Florida pompano (Trachinotus carolinus) supplemented with β‐glucan and Pediococcus acidilactici synbiotic

Journal of Fish Biology, Volume 104, Issue 4, Page 1091-1111, April 2024.
Abstract Florida pompano (Trachinotus carolinus) are a species of growing interest for commercial aquaculture. Effective health monitoring is crucial to the successful growout of the species, and prophylactic and therapeutic use of chemicals and antibiotics has been the traditional strategy for promoting stock health.
Ashley N. Morgan +5 more
wiley +1 more source

Structural Basis for Properdin Oligomerization and Convertase Stimulation in the Human Complement System

Frontiers in Immunology, 2019
Properdin (FP) is a positive regulator of the immune system stimulating the activity of the proteolytically active C3 convertase C3bBb in the alternative pathway of the complement system. Here we present two crystal structures of FP and two structures of
Dennis V. Pedersen +14 more
doaj +1 more source

THE PROPERDIN SYSTEM AND IMMUNITY [PDF]