Results 61 to 70 of about 6,114 (163)

Widely Used Commercial ELISA Does Not Detect Precursor of Haptoglobin2, but Recognizes Properdin as a Potential Second Member of the Zonulin Family

open access: yesFrontiers in Endocrinology, 2018
BackgroundThere is increasing evidence for the role of impaired intestinal permeability in obesity and associated metabolic diseases. Zonulin is an established serum marker for intestinal permeability and identical to pre-haptoglobin2.
Lucas Scheffler   +11 more
doaj   +1 more source

Endothelial damage and complement dysregulation in fetuses from pregnancies complicated by preeclampsia

open access: yesActa Obstetricia et Gynecologica Scandinavica, Volume 104, Issue 5, Page 829-838, May 2025.
Preeclampsia fetuses show an altered profile of endothelial damage and complement biomarkers, like increased adhesion molecules, prothrombotic state, oxidative stress, and reduced complement membrane attack complex deposition on endothelial cells. Abstract Introduction Our objective was to evaluate the endothelial function profile and complement system
Alex Ramos   +17 more
wiley   +1 more source

Study of the variables associated with local complement activation in IgA nephropathy

open access: yesNefrología (English Edition), 2017
Objectives: 1. To identify the variables that are associated with urinary levels of properdin, MBL, C4d, and C5b-9 in patients with idiopathic IgA nephropathy. 2. To analyse whether urinary levels of MBL and/or C4d are useful for identifying the presence
Alfons Segarra-Medrano   +6 more
doaj   +1 more source

Exosome‐Mediated Lectin Pathway and Resistin‐MIF‐AA Metabolism Axis Drive Immune Dysfunction in Immune Thrombocytopenia

open access: yesAdvanced Science, Volume 12, Issue 10, March 13, 2025.
Immune thrombocytopenia (ITP) is an autoimmune disorder marked by reduced platelet levels and heightened susceptibility to bleeding resulting from augmented autologous platelet destruction and diminished thrombopoiesis. It is found that the lectin pathway of the complement system, resistin, MIF, and AA metabolism may serve as promising targets for ...
Jin Li   +21 more
wiley   +1 more source

Biotic and abiotic factors of bactericidal properties variability of ruminant saliva

open access: yesBIO Web of Conferences, 2020
The microflora of the oral cavity of domestic ruminants, presented by transitive gram-negative species of bacteria (cocci and sticks) in cows, transient and obligate gram-positive (usually cocci) bacteria in sheep was studied. The lowest contamination of
Gilmutdinov Rustam Y.   +3 more
doaj   +1 more source

Two New Kindreds with Complete Factor D Deficiency

open access: yesEuropean Journal of Immunology, Volume 55, Issue 3, March 2025.
The complement system plays a crucial role in immune defense, and factor D deficiency is a rare immunodeficiency associated with life‐threatening bacterial infections. We report two new cases of complete factor D deficiency, including the first described in a Down syndrome patient, highlighting the need to investigate complement deficiencies in ...
Mathilde Puel   +10 more
wiley   +1 more source

Characterization of the bispecific VHH antibody tarperprumig (ALXN1820) specific for properdin and designed for low-volume administration

open access: yesmAbs
The bispecific antibody tarperprumig (ALXN1820) was developed as a treatment option for diseases involving dysregulated complement alternative pathway (AP) activity that could be administered in small volumes, either subcutaneously or intravenously ...
Paul Tamburini   +8 more
doaj   +1 more source

ISEV2025 Abstract Book

open access: yes
Journal of Extracellular Vesicles, Volume 14, Issue S1, October 2025.
wiley   +1 more source

properdin

open access: yes
Citation: 'properdin' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13612 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

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