Results 61 to 70 of about 10,182 (218)
Clinical and Experimental Immunology, 2020 Properdin is the only positive regulator of the complement system. In this study, we characterize the prevalence, functional consequences and disease associations of autoantibodies against properdin in a cohort of patients with autoimmune disease ...
M. Radanova +6 more
semanticscholar +1 more source
Immunoglobulin A Nephropathy: Molecular Pathogenesis and Targeted Therapy
MedComm, Volume 6, Issue 9, September 2025.The future of IgAN treatment likely involves combining several therapies to target multiple disease mechanisms simultaneously. Clinical trials are ongoing to evaluate the efficacy and safety of various combinations. As our understanding of IgAN pathogenesis evolves, more targeted and personalized treatment strategies are expected to emerge.
Xu‐Jie Zhou
wiley +1 more source
Protective role for properdin in progression of experimental murine atherosclerosis.
PLoS ONE, 2014 Genetic, dietary and immune factors contribute to the pathogenesis of atherosclerosis in humans and mice. Complement activation is an integral part of the innate immune defence but also shapes cellular responses and influences directly triglyceride ...
Tanja Steiner +9 more
doaj +1 more source
Frontiers in Immunology, 2022 Hidradenitis suppurativa (HS) is a chronic auto-inflammatory skin disease with a complex and multifactorial pathogenesis involving both the innate and adaptive immune system.
K. R. van Straalen +8 more
doaj +1 more source
Aging Cell, Volume 24, Issue 8, August 2025.Severe short‐term energy restriction in adults with prediabetes led to a significant reduction in circulating proteins linked to inflammation, senescence, and protein turnover. These changes, partly mediated by extracellular vesicles, suggest systemic dietary‐induced benefits beyond glycemic control, including improved aging biomarkers.
Maria Lastra Cagigas +16 more
wiley +1 more source
Diagnostics, 2021 The role and diagnostic value of the synovial complement system in patients with low-grade periprosthetic joint infection (PJI) are unclear. We sought to evaluate, for the first time, the usefulness of synovial complement factors in these patients by ...
Frank Sebastian Fröschen +6 more
doaj +1 more source
Frontiers in Immunology, 2018 Membranoproliferative glomerulonephritis (MPGN) was recently classified as C3 glomerulopathies (C3G), and immune-complex (IC) mediated MPGN. Dysregulation of the complement alternative pathway, driven by acquired and/or genetic defects, plays a ...
Roberta Donadelli +9 more
doaj +1 more source
Acta Obstetricia et Gynecologica Scandinavica, Volume 104, Issue 5, Page 829-838, May 2025.Preeclampsia fetuses show an altered profile of endothelial damage and complement biomarkers, like increased adhesion molecules, prothrombotic state, oxidative stress, and reduced complement membrane attack complex deposition on endothelial cells. Abstract Introduction Our objective was to evaluate the endothelial function profile and complement system
Alex Ramos +17 more
wiley +1 more source
Nature Communications, 2016 Many biopharmaceuticals exhibit mixed heterogeneity in their post-translational modifications (PTMs) that are essential for their function. Here the authors use a combination of mass spectrometry techniques to analyse human erythropoietin (EPO) and ...
Yang Yang +5 more
doaj +1 more source
Advanced Science, Volume 12, Issue 10, March 13, 2025.Immune thrombocytopenia (ITP) is an autoimmune disorder marked by reduced platelet levels and heightened susceptibility to bleeding resulting from augmented autologous platelet destruction and diminished thrombopoiesis. It is found that the lectin pathway of the complement system, resistin, MIF, and AA metabolism may serve as promising targets for ...
Jin Li +21 more
wiley +1 more source