Results 221 to 230 of about 1,509,901 (258)
Downregulation of Lnc-ABCA12-3 modulates UBQLN1 expression and protein homeostasis pathways in amyotrophic lateral sclerosis. [PDF]
Sci RepYu Y +5 more
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Idiopathic Pulmonary Fibrosis Caused by Damaged Mitochondria and Imbalanced Protein Homeostasis in Alveolar Epithelial Type II Cell. [PDF]
Adv Biol (Weinh)Dong Z +6 more
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Mitochondrial Protein Homeostasis and Cardiomyopathy
International Journal of Molecular Sciences, 2022 Human mitochondrial disorders impact tissues with high energetic demands and can be associated with cardiac muscle disease (cardiomyopathy) and early mortality. However, the mechanistic link between mitochondrial disease and the development of cardiomyopathy is frequently unclear.
Aneal Khan +2 more
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Rescuing protein homeostasis [PDF]
Nature Reviews Drug Discovery, 2012 Sarah Crunkhorn
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Protein homeostasis from the outside in
Nature Cell Biology, 2020Secretory proteins undergo multiple rounds of co- and post-translational quality control checks inside the cell, but how their integrity is maintained outside the cell is an emerging topic. A study establishes a model system to investigate how the extracellular proteome is protected and integrates its findings into existing immune pathways.
Brant M, Webster +2 more
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Citrulline production and protein homeostasis
Current Opinion in Clinical Nutrition & Metabolic Care, 2019Protein homeostasis is crucial for maintaining cell functions. Citrulline, an endogenous amino acid, is considered as an efficient source of arginine at systemic and cellular level. Accumulating evidence, obtained from citrulline supplementation studies, suggest anabolic properties especially in malnourished rodents and human.
Antonin, Ginguay, Jean-Pascal, De Bandt
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Mitochondrial control of cellular protein homeostasis [PDF]
Biochemical Journal, 2020 Mitochondria are involved in several vital functions of the eukaryotic cell. The majority of mitochondrial proteins are coded by nuclear DNA. Constant import of proteins from the cytosol is a prerequisite for the efficient functioning of the organelle. The protein import into mitochondria is mediated by diverse import pathways and is continuously under
Karthik Mohanraj +2 more
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Protein Intake and Calcium Homeostasis
1994The earliest study documenting the relationship between dietary protein and urinary calcium was published 70 years ago. Sherman (1920) reported that an all-meat diet fed to humans increased urinary calcium. Twenty years later McCance et al. (1942) confirmed this observation by showing that peptones, gluten, gelatin or egg white added to the diet ...
J E, Kerstetter, L H, Allen
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Dysfunction of protein homeostasis in myotonic dystrophies.
Histology and histopathology, 2013Neuromuscular diseases Myotonic Dystrophies type 1 and type 2 (DM1 and DM2) are caused by unstable CTG and CCTG repeat expansions and have highly complex molecular mechanisms. DM1 is caused by the expansion of CTG repeats in the 3' UTR of the gene coding for Dystrophia Myotonica-Protein Kinase (DMPK). In DM2, intronic CCTG repeats are located in a gene
G. Meola +3 more
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Small-Molecule Modulation of Protein Homeostasis
Chemical Reviews, 2017Control of protein levels by nucleic-acid-based technologies has proven to be a useful research tool but lacks the advantages of small molecules with respect to cell permeability, temporal control, and the potential generation of therapeutics. In this Review, we discuss the technologies available for the control of intracellular protein levels with ...
George M. Burslem, Craig M. Crews
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