Results 261 to 270 of about 1,905,470 (305)

Exosomal misfolded proteins released by cancer stem cells: dual functions in balancing protein homeostasis and orchestrating tumor progression. [PDF]

Discov Oncol
Bhattacharya A, Chatterji U.
europepmc   +1 more source

Microphysiological Systems of Lymphatics and Immune Organs

Advanced Healthcare Materials, EarlyView.
This review surveys recent progress in engineering lymphatic microenvironments and immune organoids within microphysiological systems, emphasizing innovative strategies to recreate the biochemical and biophysical complexity of native lymphatic tissues.
Ishita Jain, Ankur Singh, Andrés J. García   +2 more
wiley   +1 more source

Spherical Skin Model: Stratified Co‐Culture of Fibroblasts and Keratinocytes on Spherical Beads Toward Compound Screening

Advanced Healthcare Materials, EarlyView.
Models of the human skin must combine the relevant biological contents and suitable biomaterials with the correct spatial organization. Performing compound screening on such in vitro models also requires fast and reproducible production methods of the models.
Elisa Lenzi, Nadia Vertti‐Quintero, Julien Husson, Anne‐Laure Bulteau, Carine Nizard, Karl Pays, Sébastien Sart, Charles N. Baroud   +7 more
wiley   +1 more source

New Insights into Atonic Postpartum Hemorrhage: Animal Model Construction Based on Placental Nanodelivery Systems

Advanced Healthcare Materials, EarlyView.
This study develops a placenta‐targeted nanodelivery system co‐loading HMGB1 protein and the NLRP3 agonist nigericin to establish an animal model of atonic postpartum hemorrhage. The model accurately recapitulates clinical phenotypes, including prolonged labor and uterine contractility dysfunction, while revealing inflammatory activation in placental ...
Jiangxue Qu, Ruiqi Wu, Hai Jiang, Lian Chen, Yingying Tian, Shuai Zeng, Tongmin Liu, Cheng Zhao, Huifeng Shi, Xiaolong Liang, Yangyu Zhao   +10 more
wiley   +1 more source

Simultaneous proteome localization and turnover analysis reveals spatiotemporal features of protein homeostasis disruptions. [PDF]

Nat Commun
Currie J, Manda V, Robinson SK, Lai C, Agnihotri V, Hidalgo V, Ludwig RW, Zhang K, Pavelka J, Wang ZV, Rhee JW, Lam MPY, Lau E.   +12 more
europepmc   +1 more source

Mitochondrial Dysfunction and Protein Homeostasis in Aging: Insights from a Premature-Aging Mouse Model. [PDF]

Biomolecules
Ross JM, Olson L, Coppotelli G.
europepmc   +1 more source

Role of Yme1 in mitochondrial protein homeostasis: from regulation of protein import, OXPHOS function to lipid synthesis and mitochondrial dynamics. [PDF]

Biochem Soc Trans
Kan KT, Wilcock J, Lu H.
europepmc   +1 more source

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Citrulline production and protein homeostasis

Current Opinion in Clinical Nutrition & Metabolic Care, 2019
Protein homeostasis is crucial for maintaining cell functions. Citrulline, an endogenous amino acid, is considered as an efficient source of arginine at systemic and cellular level. Accumulating evidence, obtained from citrulline supplementation studies, suggest anabolic properties especially in malnourished rodents and human.
Antonin, Ginguay, Jean-Pascal, De Bandt
openaire   +2 more sources

Protein homeostasis from the outside in

Nature Cell Biology, 2020
Secretory proteins undergo multiple rounds of co- and post-translational quality control checks inside the cell, but how their integrity is maintained outside the cell is an emerging topic. A study establishes a model system to investigate how the extracellular proteome is protected and integrates its findings into existing immune pathways.
Brant M, Webster, Holly K, Gildea, Andrew, Dillin   +2 more
openaire   +2 more sources

Protein Intake and Calcium Homeostasis

1994
The earliest study documenting the relationship between dietary protein and urinary calcium was published 70 years ago. Sherman (1920) reported that an all-meat diet fed to humans increased urinary calcium. Twenty years later McCance et al. (1942) confirmed this observation by showing that peptones, gluten, gelatin or egg white added to the diet ...
J E, Kerstetter, L H, Allen
openaire   +2 more sources