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2011
Iron is essential for a number of biochemical functions in the body including the transport of oxygen in the blood and energy production in the mitochondria. Therefore, humans require an abundant and regular source of dietary iron to maintain normal health.
Surjit Kaila Srai, Paul Sharp
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Iron is essential for a number of biochemical functions in the body including the transport of oxygen in the blood and energy production in the mitochondria. Therefore, humans require an abundant and regular source of dietary iron to maintain normal health.
Surjit Kaila Srai, Paul Sharp
openaire +1 more source
Small-Molecule Modulation of Protein Homeostasis
Chemical Reviews, 2017Control of protein levels by nucleic-acid-based technologies has proven to be a useful research tool but lacks the advantages of small molecules with respect to cell permeability, temporal control, and the potential generation of therapeutics. In this Review, we discuss the technologies available for the control of intracellular protein levels with ...
George M. Burslem, Craig M. Crews
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DNA damage and regulation of protein homeostasis
DNA Repair, 2021The accumulation of unrepaired DNA lesions is associated with many pathological outcomes in humans, particularly in neurodegenerative diseases and in normal aging. Evidence supporting a causal role for DNA damage in the onset and progression of neurodegenerative disease has come from rare human patients with mutations in DNA damage response genes as ...
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The prion protein and neuronal zinc homeostasis
Trends in Biochemical Sciences, 2003Although the prion protein (PrP) is known to be the causative agent of the neurodegenerative transmissible spongiform encephalopathies, its normal cellular function remains elusive. Octapeptide repeats in the N terminus of PrP bind metal ions and are required for the endocytosis of PrP upon exposure of cells to copper or zinc.
Nicole T, Watt, Nigel M, Hooper
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Proteomic analysis of protein homeostasis and aggregation
Journal of Proteomics, 2019Protein homeostasis (proteostasis) refers to the ability of cells to preserve the correct balance between protein synthesis, folding and degradation. Proteostasis is essential for optimal cell growth and survival under stressful conditions. Various extracellular and intracellular stresses including heat shock, oxidative stress, proteasome malfunction ...
Ewa Laskowska +2 more
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Protein homeostasis in chronic hemodialysis patients
Current Opinion in Clinical Nutrition and Metabolic Care, 2004Nutritional status is an important predictor of clinical outcome in chronic hemodialysis patients, as uremic malnutrition is strongly associated with an increased risk of death and hospitalization events. Decreased muscle mass is the most significant predictor of morbidity and mortality in these patients.
Lara B, Pupim +2 more
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Breathing for protein function and [H+] homeostasis
Respiration Physiology, 1993Based on a physicochemical analysis of H+ homeostasis, we hypothesize that PCO2 and strong ions, and not [H+], act independently on chemosensors in the central nervous system to regulate ventilation. [H+] in body fluids and the pK of histidine imidazole groups of proteins must be regulated in relation to each other to preserve protein conformation and ...
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The tumour-promoting role of protein homeostasis: Implications for cancer immunotherapy
Cancer Letters, 2023JinCheng Wang, Xiaojie Lu, Huabing Tan
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Mechanisms of Endoplasmic Reticulum Protein Homeostasis in Plants
International Journal of Molecular Sciences, 2023Linchuan Liu, Jianming Li, Zhihao Duan
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