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2011
Iron is essential for a number of biochemical functions in the body including the transport of oxygen in the blood and energy production in the mitochondria. Therefore, humans require an abundant and regular source of dietary iron to maintain normal health.
Surjit Kaila Srai, Paul Sharp
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Iron is essential for a number of biochemical functions in the body including the transport of oxygen in the blood and energy production in the mitochondria. Therefore, humans require an abundant and regular source of dietary iron to maintain normal health.
Surjit Kaila Srai, Paul Sharp
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Sarcopenia: Tilting the Balance of Protein Homeostasis
PROTEOMICS, 2019AbstractSarcopenia, defined as age‐associated decline of muscle mass and function, is a risk factor for mortality and disability, and comorbid with several chronic diseases such as type II diabetes and cardiovascular diseases. Clinical trials showed that nutritional supplements had positive effects on muscle mass, but not on muscle function and ...
Kuan Ting Tan +2 more
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Nutrition and protein energy homeostasis in elderly
Mechanisms of Ageing and Development, 2014Protein-energy homeostasis is a major determinant of healthy aging. Inadequate nutritional intakes and physical activity, together with endocrine disturbances are associated with of sarcopenia and frailty. Guidelines from scientific societies mainly address the quantitative aspects of protein and energy nutrition in elderly.
Boirie, Y. +3 more
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Small-Molecule Modulation of Protein Homeostasis
Chemical Reviews, 2017Control of protein levels by nucleic-acid-based technologies has proven to be a useful research tool but lacks the advantages of small molecules with respect to cell permeability, temporal control, and the potential generation of therapeutics. In this Review, we discuss the technologies available for the control of intracellular protein levels with ...
George M. Burslem, Craig M. Crews
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Proteomic analysis of protein homeostasis and aggregation
Journal of Proteomics, 2019Protein homeostasis (proteostasis) refers to the ability of cells to preserve the correct balance between protein synthesis, folding and degradation. Proteostasis is essential for optimal cell growth and survival under stressful conditions. Various extracellular and intracellular stresses including heat shock, oxidative stress, proteasome malfunction ...
Ewa Laskowska +2 more
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Protein homeostasis in chronic hemodialysis patients
Current Opinion in Clinical Nutrition and Metabolic Care, 2004Nutritional status is an important predictor of clinical outcome in chronic hemodialysis patients, as uremic malnutrition is strongly associated with an increased risk of death and hospitalization events. Decreased muscle mass is the most significant predictor of morbidity and mortality in these patients.
Lara B, Pupim +2 more
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Protein homeostasis and molecular chaperones in aging
Biogerontology, 2006Molecular chaperones are ubiquitous, highly conserved proteins responsible for the maintenance of protein folding homeostasis in cells. Environmental stress causes proteotoxic damage, which triggers chaperone induction and the subsequent reparation of cellular damage by chaperones, including disposing irreparable protein ensembles.
Mehmet Alper, Arslan +2 more
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Dysfunction of protein homeostasis in myotonic dystrophies.
Histology and histopathology, 2013Neuromuscular diseases Myotonic Dystrophies type 1 and type 2 (DM1 and DM2) are caused by unstable CTG and CCTG repeat expansions and have highly complex molecular mechanisms. DM1 is caused by the expansion of CTG repeats in the 3' UTR of the gene coding for Dystrophia Myotonica-Protein Kinase (DMPK). In DM2, intronic CCTG repeats are located in a gene
G. Meola +3 more
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Breathing for protein function and [H+] homeostasis
Respiration Physiology, 1993Based on a physicochemical analysis of H+ homeostasis, we hypothesize that PCO2 and strong ions, and not [H+], act independently on chemosensors in the central nervous system to regulate ventilation. [H+] in body fluids and the pK of histidine imidazole groups of proteins must be regulated in relation to each other to preserve protein conformation and ...
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