Results 261 to 270 of about 5,116,336 (302)
RecA deletion disrupts protein homeostasis, leading to deamidation, oxidation, and impaired glycolysis in Cronobacter sakazakii. [PDF]
Appl Environ MicrobiolLu P, Xue J, Ji X.
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Mitochondrial Protein Homeostasis and Cardiomyopathy
International Journal of Molecular Sciences, 2022 Human mitochondrial disorders impact tissues with high energetic demands and can be associated with cardiac muscle disease (cardiomyopathy) and early mortality. However, the mechanistic link between mitochondrial disease and the development of cardiomyopathy is frequently unclear.
Timothy Shutt, Steven Greenway
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Protein homeostasis in aging and cancer
Frontiers in Cell and Developmental Biology, 2023 Aging is a major risk factor for cancer development. As dysfunction in protein homeostasis, or proteostasis, is a universal hallmark of both the aging process and cancer, a comprehensive understanding of the proteostasis system and its roles in aging and cancer will shed new light on how we can improve health and quality of life for older individuals ...
Xiao-Qiong Chen
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Rescuing protein homeostasis [PDF]
Nature Reviews Drug Discovery, 2012 Sarah Crunkhorn
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Protein homeostasis from the outside in
Nature Cell Biology, 2020Secretory proteins undergo multiple rounds of co- and post-translational quality control checks inside the cell, but how their integrity is maintained outside the cell is an emerging topic. A study establishes a model system to investigate how the extracellular proteome is protected and integrates its findings into existing immune pathways.
Brant M, Webster +2 more
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Citrulline production and protein homeostasis
Current Opinion in Clinical Nutrition & Metabolic Care, 2019Protein homeostasis is crucial for maintaining cell functions. Citrulline, an endogenous amino acid, is considered as an efficient source of arginine at systemic and cellular level. Accumulating evidence, obtained from citrulline supplementation studies, suggest anabolic properties especially in malnourished rodents and human.
Antonin, Ginguay, Jean-Pascal, De Bandt
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Protein Intake and Calcium Homeostasis
1994The earliest study documenting the relationship between dietary protein and urinary calcium was published 70 years ago. Sherman (1920) reported that an all-meat diet fed to humans increased urinary calcium. Twenty years later McCance et al. (1942) confirmed this observation by showing that peptones, gluten, gelatin or egg white added to the diet ...
J E, Kerstetter, L H, Allen
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Mitochondrial control of cellular protein homeostasis [PDF]
Biochemical Journal, 2020 Mitochondria are involved in several vital functions of the eukaryotic cell. The majority of mitochondrial proteins are coded by nuclear DNA. Constant import of proteins from the cytosol is a prerequisite for the efficient functioning of the organelle. The protein import into mitochondria is mediated by diverse import pathways and is continuously under
Karthik Mohanraj +2 more
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DNA damage and regulation of protein homeostasis
DNA Repair, 2021The accumulation of unrepaired DNA lesions is associated with many pathological outcomes in humans, particularly in neurodegenerative diseases and in normal aging. Evidence supporting a causal role for DNA damage in the onset and progression of neurodegenerative disease has come from rare human patients with mutations in DNA damage response genes as ...
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