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Lipid Homeostasis and Its Links With Protein Misfolding Diseases [PDF]
Frontiers in Molecular Neuroscience, 2022 The maintenance of lipid homeostasis is essential for the normal functioning of living organisms. Alterations of the lipid homeostasis system remodel the composition of the lipidome, potentially leading to the formation of toxic lipid species.
Michele Vendruscolo
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The role of rhomboid superfamily members in protein homeostasis: Mechanistic insight and physiological implications [PDF]
Biochimica Et Biophysica Acta - Molecular Cell Research, 2020 Cells are equipped with protein quality control pathways in order to maintain a healthy proteome; a process known as protein homeostasis. Dysfunction in protein homeostasis leads to the development of many diseases that are associated with ...
Sonya E Neal
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Rescuing protein homeostasis [PDF]
Nature Reviews Drug Discovery, 2012 Sarah Crunkhorn
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Protein homeostasis from the outside in
Nature Cell Biology, 2020Secretory proteins undergo multiple rounds of co- and post-translational quality control checks inside the cell, but how their integrity is maintained outside the cell is an emerging topic. A study establishes a model system to investigate how the extracellular proteome is protected and integrates its findings into existing immune pathways.
Brant M, Webster +2 more
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Mitochondrial control of cellular protein homeostasis [PDF]
Biochemical Journal, 2020 Mitochondria are involved in several vital functions of the eukaryotic cell. The majority of mitochondrial proteins are coded by nuclear DNA. Constant import of proteins from the cytosol is a prerequisite for the efficient functioning of the organelle. The protein import into mitochondria is mediated by diverse import pathways and is continuously under
Karthik Mohanraj +2 more
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Oxidized proteins and their contribution to redox homeostasis
Redox Report, 2005 Proteins are major target for radicals and other oxidants when these are formed in both intra- and extracellular environments in vivo. Formation of lesions on proteins may be highly sensitive protein-based biomarkers for oxidative damage in mammalian systems.
Gregorio Martinez-Sanchez +1 more
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Citrulline production and protein homeostasis
Current Opinion in Clinical Nutrition & Metabolic Care, 2019Protein homeostasis is crucial for maintaining cell functions. Citrulline, an endogenous amino acid, is considered as an efficient source of arginine at systemic and cellular level. Accumulating evidence, obtained from citrulline supplementation studies, suggest anabolic properties especially in malnourished rodents and human.
Antonin, Ginguay, Jean-Pascal, De Bandt
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Protein Intake and Calcium Homeostasis
1994The earliest study documenting the relationship between dietary protein and urinary calcium was published 70 years ago. Sherman (1920) reported that an all-meat diet fed to humans increased urinary calcium. Twenty years later McCance et al. (1942) confirmed this observation by showing that peptones, gluten, gelatin or egg white added to the diet ...
J E, Kerstetter, L H, Allen
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Sarcopenia: Tilting the Balance of Protein Homeostasis
PROTEOMICS, 2019AbstractSarcopenia, defined as age‐associated decline of muscle mass and function, is a risk factor for mortality and disability, and comorbid with several chronic diseases such as type II diabetes and cardiovascular diseases. Clinical trials showed that nutritional supplements had positive effects on muscle mass, but not on muscle function and ...
Kuan Ting Tan +2 more
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Nutrition and protein energy homeostasis in elderly
Mechanisms of Ageing and Development, 2014Protein-energy homeostasis is a major determinant of healthy aging. Inadequate nutritional intakes and physical activity, together with endocrine disturbances are associated with of sarcopenia and frailty. Guidelines from scientific societies mainly address the quantitative aspects of protein and energy nutrition in elderly.
Boirie, Y. +3 more
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