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Mitochondrial control of cellular protein homeostasis
Biochemical Journal, 2020Mitochondria are involved in several vital functions of the eukaryotic cell. The majority of mitochondrial proteins are coded by nuclear DNA. Constant import of proteins from the cytosol is a prerequisite for the efficient functioning of the organelle. The protein import into mitochondria is mediated by diverse import pathways and is continuously under
Karthik Mohanraj +2 more
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Small-Molecule Modulation of Protein Homeostasis
Chemical Reviews, 2017Control of protein levels by nucleic-acid-based technologies has proven to be a useful research tool but lacks the advantages of small molecules with respect to cell permeability, temporal control, and the potential generation of therapeutics. In this Review, we discuss the technologies available for the control of intracellular protein levels with ...
George M. Burslem, Craig M. Crews
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Protein homeostasis in chronic hemodialysis patients
Current Opinion in Clinical Nutrition and Metabolic Care, 2004Nutritional status is an important predictor of clinical outcome in chronic hemodialysis patients, as uremic malnutrition is strongly associated with an increased risk of death and hospitalization events. Decreased muscle mass is the most significant predictor of morbidity and mortality in these patients.
Lara B, Pupim +2 more
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2011
Iron is essential for a number of biochemical functions in the body including the transport of oxygen in the blood and energy production in the mitochondria. Therefore, humans require an abundant and regular source of dietary iron to maintain normal health.
Surjit Kaila Srai, Paul Sharp
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Iron is essential for a number of biochemical functions in the body including the transport of oxygen in the blood and energy production in the mitochondria. Therefore, humans require an abundant and regular source of dietary iron to maintain normal health.
Surjit Kaila Srai, Paul Sharp
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Protein homeostasis limiting cancer
Science Signaling, 2016A protein involved in protein homeostasis limits the maturation of IGF1R and the overproduction of blood cells.
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Presynaptic protein homeostasis and neuronal function
Current Opinion in Genetics & Development, 2017Proteome integrity is maintained by a coordinated network of molecular chaperones, by protein degradation machineries and by their regulators. Numerous human pathologies are considered as diseases of compromised protein homeostasis (proteostasis), including neurodegeneration.
Wang, Yu-Chun +2 more
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The contemporary management of cancers of the sinonasal tract in adults
Ca-A Cancer Journal for Clinicians, 2023Rajat Thawani
exaly
The protein corona from nanomedicine to environmental science
Nature Reviews Materials, 2023Assist Prof Morteza Mahmoudi +2 more
exaly