Results 51 to 60 of about 1,466,359 (163)
Lipin proteins and metabolic homeostasis
Journal of Lipid Research, 2009 The lipin protein family, consisting of three members, was first identified early this century. In the last few years, the lipin proteins have been shown to have important roles in glycerolipid biosynthesis and gene regulation, and mutations in the corresponding genes cause lipodystrophy, myoglobinuria, and inflammatory disorders.
Karen Reue, Jennifer R. Dwyer
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Interplay between redox and protein homeostasis [PDF]
Worm, 2016 The subcellular compartments of eukaryotic cells are characterized by different redox environments. Whereas the cytosol, nucleus and mitochondria are more reducing, the endoplasmic reticulum represents a more oxidizing environment. As the redox level controls the formation of intra- and inter-molecular disulfide bonds, the folding of proteins is ...
Feleciano, Diogo R. +2 more
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Integrating Protein Homeostasis Strategies in Prokaryotes [PDF]
Cold Spring Harbor Perspectives in Biology, 2010 Bacterial cells are frequently exposed to dramatic fluctuations in their environment, which cause perturbation in protein homeostasis and lead to protein misfolding. Bacteria have therefore evolved powerful quality control networks consisting of chaperones and proteases that cooperate to monitor the folding states of proteins and to remove misfolded ...
Axel, Mogk, Damon, Huber, Bernd, Bukau
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Protein homeostasis and aging in neurodegeneration [PDF]
The Journal of Experimental Medicine, 2010 Genetic and environmental factors responsible for numerous neurodegenerative diseases vary between disorders, yet age remains a universal risk factor. Age-associated decline in protein homeostasis, or proteostasis, enables disease-linked proteins to adopt aberrant tertiary structures, accumulate as higher-ordered aggregates, and cause a myriad of ...
Douglas, Peter M., Dillin, Andrew
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Bio-ProtocolAccurate measurement of protein translation rates is crucial for understanding cellular processes and disease mechanisms. However, existing methods for quantifying translation rates in yeast cells are limited.
Mainak Jha, Koyeli Mapa
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Selective Autophagy of the Protein Homeostasis Machinery: Ribophagy, Proteaphagy and ER-Phagy
Frontiers in Cell and Developmental Biology, 2020 The eukaryotic cell has developed intricate machineries that monitor and maintain proteome homeostasis in order to ensure cellular functionality. This involves the carefully coordinated balance between protein synthesis and degradation pathways, which ...
Carsten J. Beese +4 more
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Protein Homeostasis, Aging and Alzheimer’s Disease [PDF]
Molecular Neurobiology, 2012 Alzheimer's disease (AD) is one key medical challenge of the aging society and despite a great amount of effort and a huge collection of acquired data on molecular mechanisms that are associated with the onset and progression of this devastating disorder, no causal therapy is in sight.
Morawe, Tobias +3 more
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Cellular maintenance of nuclear protein homeostasis [PDF]
Cellular and Molecular Life Sciences, 2013 The accumulation and aggregation of misfolded proteins is the primary hallmark for more than 45 human degenerative diseases. These devastating disorders include Alzheimer's, Parkinson's, Huntington's, and amyotrophic lateral sclerosis. Over 15 degenerative diseases are associated with the aggregation of misfolded proteins specifically in the nucleus of
Pamela S. Gallagher +4 more
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ANKZF1 helps to eliminate stress-damaged mitochondria by LC3-mediated mitophagy
Cell Death DiscoveryMitochondria, the double membrane-bound organelles of endosymbiotic origin, are crucial centers for cellular energy production and several essential metabolic pathways.
Mudassar Ali, Anjali, Koyeli Mapa
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Molecular & Cellular Oncology, 2018 Protein misfolding and protein aggregation are linked to several diseases commonly called as proteinopathies, which include cancer. Understanding the mechanisms of proteostasis could provide newer strategies to combat proteinopathies.
Kautilya Kumar Jena +4 more
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