Results 61 to 70 of about 1,466,359 (163)

Protein homeostasis: live long, won't prosper [PDF]

Nature Reviews Molecular Cell Biology, 2012
Protein turnover is an effective way of maintaining a functional proteome, as old and potentially damaged polypeptides are destroyed and replaced by newly synthesized copies. An increasing number of intracellular proteins, however, have been identified that evade this turnover process and instead are maintained over a cell's lifetime.
Brandon H, Toyama, Martin W, Hetzer
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Suppressing proteasome activity enhances sensitivity to actinomycin D in diffuse anaplastic Wilms tumor

Cell Reports Medicine
Summary: Wilms tumor is the most common pediatric kidney cancer, and diffuse anaplastic Wilms tumor is the most chemoresistant subtype. Here, we explore how Wilms tumor cells evade the chemotherapy actinomycin D, which inhibits ribosomal RNA biogenesis ...
Patricia D.B. Tiburcio, Kenian Chen, Lin Xu, Kenneth S. Chen   +3 more
doaj   +1 more source

Current Status and Challenges in Treatment of Relapsed/Refractory Multiple Myeloma

Zhongliu Fangzhi Yanjiu, 2019
Multiple myeloma remains an incurable hematological malignancy. In recent years, the application of many agents has improved the survival and life quality of patients.
WAN Yike, HOU Jian
doaj   +1 more source

tRNA wobble modifications and protein homeostasis [PDF]

Translation, 2016
tRNA is a central component of the protein synthesis machinery in the cell. In living cells, tRNAs undergo numerous post-transcriptional modifications. In particular, modifications at the anticodon loop play an important role in ensuring efficient protein synthesis, maintaining protein homeostasis, and helping cell adaptation and survival.
Ranjan, N., Rodnina, M.
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Prions, protein homeostasis, and phenotypic diversity [PDF]

Trends in Cell Biology, 2010
Prions are fascinating but often misunderstood protein aggregation phenomena. The traditional association of the mammalian prion protein with disease has overshadowed a potentially more interesting attribute of prions: their ability to create protein-based molecular memories.
Lindquist, Susan, Halfmann, Randal Arthur, Alberti, Simon   +2 more
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α-Synuclein Decreases the Abundance of Proteasome Subunits and Alters Ubiquitin Conjugates in Yeast

Cells, 2021
Parkinson’s disease (PD) is the most prevalent movement disorder characterized with loss of dopaminergic neurons in the brain. One of the pathological hallmarks of the disease is accumulation of aggregated α-synuclein (αSyn) in cytoplasmic Lewy body ...
Blagovesta Popova, Dajana Galka, Nicola Häffner, Dan Wang, Kerstin Schmitt, Oliver Valerius, Michael Knop, Gerhard H. Braus   +7 more
doaj   +1 more source

ALS’ Perfect Storm: C9orf72-Associated Toxic Dipeptide Repeats as Potential Multipotent Disruptors of Protein Homeostasis

Cells
Protein homeostasis is essential for neuron longevity, requiring a balanced regulation between protein synthesis and degradation. The clearance of misfolded and aggregated proteins, mediated by autophagy and the ubiquitin–proteasome systems, maintains ...
Paulien H. Smeele, Giuliana Cesare, Thomas Vaccari   +2 more
doaj   +1 more source

Bone morphogenic proteins in iron homeostasis

Bone, 2020
The bone morphogenetic protein (BMP)-SMAD signaling pathway plays a central role in regulating hepcidin, which is the master hormone governing systemic iron homeostasis. Hepcidin is produced by the liver and acts on the iron exporter ferroportin to control iron absorption from the diet and iron release from body stores, thereby providing adequate iron ...
Xia, Xiao, Víctor M, Alfaro-Magallanes, Jodie L, Babitt   +2 more
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Extracellular matrix fragmentation in young, healthy cartilaginous tissues [PDF]

European Cells & Materials, 2018
Although the composition and structure of cartilaginous tissues is complex, collagen II fibrils and aggrecan are the most abundant assemblies in both articular cartilage (AC) and the nucleus pulposus (NP) of the intervertebral disc (IVD).
RJ Craddock, NW Hodson, M Ozols, T Shearer, JA Hoyland, MJ Sherratt   +5 more
doaj   +1 more source

Orm family proteins mediate sphingolipid homeostasis. [PDF]

The FASEB Journal, 2010
Despite the essential roles of sphingolipids both as structural components of membranes and critical signalling molecules, we have a limited understanding of how cells sense and regulate their levels. Here we reveal the function in sphingolipid metabolism of the ORM genes (known as ORMDL genes in humans)-a conserved gene family that includes ORMDL3 ...
Breslow, David K, Collins, Sean R, Bodenmiller, Bernd, Aebersold, Ruedi, Simons, Kai, Shevchenko, Andrej, Ejsing, Christer S, Weissman, Jonathan S   +7 more
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