Results 71 to 80 of about 1,466,359 (163)
How chloroplasts protect themselves from unfolded proteins
eLife, 2019 A genetic screen has identified the first signaling component of the unfolded protein response in chloroplasts.
Felix Kessler, Paolo Longoni
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Proteostasis disruption under hypoxia: therapeutic targets in cancer and neurodegenerative diseases
Acta Biochimica IndonesianaProteostasis, the integrated network regulating protein synthesis, folding, trafficking, and degradation, is essential for cellular function and organismal health.
Susi Rahmiyati +3 more
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Protein Homeostasis at the Plasma Membrane
Physiology, 2014 The plasma membrane (PM) and endocytic protein quality control (QC) in conjunction with the endosomal sorting machinery either repairs or targets conformationally damaged membrane proteins for lysosomal/vacuolar degradation. Here, we provide an overview of emerging aspects of the underlying mechanisms of PM QC that fulfill a critical role in preserving
Pirjo M, Apaja, Gergely L, Lukacs
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CBS Domain Proteins Regulate Redox Homeostasis [PDF]
The Plant Cell, 2011 fluorescent protein fusion localized to the chloroplast. In the chloroplast, CBSX1 interacted with four distinct thioredoxins, as shown by yeast two-hybrid and in vitro pull-down studies. The interaction of CBSX1 and thioredoxin also occurred in living plant cells, as shown by bimolecular fluorescence complementation analysis in tobacco (Nicotiana ...
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Frontiers in Marine ScienceTitanium dioxide nanoparticles (TiO2-NPs) released into the environment is becoming more prevalent due to their increased usage, marine TiO2-NPs contamination is escalating concerns in coastal areas.
Fengfeng Li +10 more
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Quantification of mRNA and protein and integration with protein turnover in a bacterium
Molecular Systems Biology, 2011 Biological function and cellular responses to environmental perturbations are regulated by a complex interplay of DNA, RNA, proteins and metabolites inside cells.
Tobias Maier +6 more
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Frontiers in Cell and Developmental BiologyAlzheimer’s disease (AD) is a neurodegenerative disorder clinically characterized by progressive decline of memory and cognitive functions, and it is the leading cause of dementia accounting for 60%–80% of dementia patients. A pathological hallmark of AD
Sofia Miranda Fernandes +3 more
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Insulin-Degrading Enzyme Regulates mRNA Processing and May Interact with the CCR4-NOT Complex
CellsInsulin-degrading enzyme is a zinc metalloprotease that degrades low-molecular-weight substrates, including insulin. Ubiquitous expression, high evolutionary conservation, upregulation of Ide in stress situations, and literature findings suggest a ...
Barbara Bertocci +6 more
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Open BiologyMutations in the protein superoxide dismutase-1 (SOD1) promote its misfolding and aggregation, ultimately causing familial forms of the debilitating neurodegenerative disease amyotrophic lateral sclerosis (ALS).
Luke McAlary +5 more
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