Results 21 to 30 of about 4,093 (168)

Functional Identification and Structural Analysis of a New Lipoate Protein Ligase in Mycoplasma hyopneumoniae [PDF]

, 2020
Mycoplasma hyopneumoniae (M. hyopneumoniae) is the causative agent of pandemic pneumonia among pigs, namely, swine enzootic pneumonia. Although M. hyopneumoniae was first identified in 1965, little is known regarding its metabolic pathways, which might ...
CHEN, H, Feng, Y, Huang, J, Jin, J, Liu, H, Ma, G, Wang, N, Xin, J, Zhang, H, Zhu, K   +9 more
core   +1 more source

Protein-Interaction Affinity Gradient Drives [4Fe–4S] Cluster Insertion in Human Lipoyl Synthase

Journal of the American Chemical Society, 2022
Human lipoyl synthase (LIAS) is an enzyme containing two [4Fe-4S] clusters (named FeSRS and FeSaux) involved in the biosynthesis of the lipoyl cofactor. The mechanism by which a [4Fe-4S] cluster is inserted into LIAS has thus far remained elusive. Here we show that NFU1 and ISCA1 of the mitochondrial iron-sulfur cluster assembly machinery, via forming ...
Saudino, Giovanni, Ciofi-Baffoni, Simone, Banci, Lucia   +2 more
openaire   +3 more sources

Clinical and genetic aspects of defects in the mitochondrial iron-sulfur cluster synthesis pathway [PDF]

, 2018
Iron-sulfur clusters are evolutionarily conserved biological structures which play an important role as cofactor for multiple enzymes in eukaryotic cells.
Van Coster, Rudy, Vanlander, Arnaud
core   +2 more sources

Clinical, biochemical, and genetic spectrum of seven patients with NFU1 deficiency [PDF]

, 2015
Disorders of the mitochondrial energy metabolism are clinically and genetically heterogeneous. An increasingly recognized subgroup is caused by defective mitochondrial iron-sulfur (Fe-S) cluster biosynthesis, with defects in 13 genes being linked to ...
Angela eHagendorff, Arnaud V Vanlander, Barbara ePlecko, Boris eRolinski, Charlotte L Alston, Christine eMakowski, Franz A Zimmermann, Holger eProkisch, Holger eProkisch, Johannes A Mayr, Joél eSmet, Lucia eAbela, Maja eHempel, Marianne eRohrbach, Peter eFreisinger, Robert W Taylor, Rudy eVan Coster, Saikat eSantra, Sara eSeneka, Stephanie eSpranger, Steven A Hardy, Thomas eMeitinger, Thomas eMeitinger, Tobias Bernd Haack, Tobias Bernd Haack, Uwe eAhting, Wolfgang eSperl   +26 more
core   +3 more sources

Lipoate-Protein Ligase and Octanoyltransferase Are Essential for Protein Lipoylation in Mitochondria of Arabidopsis     [PDF]

Plant Physiology, 2014
AbstractProsthetic lipoyl groups are required for the function of several essential multienzyme complexes, such as pyruvate dehydrogenase (PDH), α-ketoglutarate dehydrogenase (KGDH), and the glycine cleavage system (glycine decarboxylase [GDC]). How these proteins are lipoylated has been extensively studied in prokaryotes and yeast (Saccharomyces ...
Ralph, Ewald, Christiane, Hoffmann, Alexandra, Florian, Ekkehard, Neuhaus, Alisdair R, Fernie, Hermann, Bauwe   +5 more
openaire   +2 more sources

Genome-wide identification of genes involved in the positive and negative regulation of acetic acid-induced programmed cell death in Saccharomyces cerevisiae [PDF]

, 2013
Background: Acetic acid is mostly known as a toxic by-product of alcoholic fermentation carried out by Saccharomyces cerevisiae, which it frequently impairs. The more recent finding that acetic acid triggers apoptotic programmed cell death (PCD) in yeast
Chaves, S. R., Côrte-Real, Manuela, Duarte, Ana Marta Gomes, Fernandes, Tânia Alícia Ribeiro, Leão, Cecília, Pacheco, Andreia, Sousa, Maria João, Sousa, Marlene   +7 more
core   +2 more sources

Nitric oxide-driven modifications of lipoic arm inhibit α-ketoacid dehydrogenases [PDF]

, 2022
Pyruvate dehydrogenase complex (PDHC) and oxoglutarate dehydrogenase complex (OGDC), which belong to the mitochondrial α-ketoacid dehydrogenase family, play crucial roles in cellular metabolism.
Arp, Nicholas L, Fan, Jing, Fang, Zixiang, John, Steven V, Pagliarini, David J, Seim, Gretchen L   +5 more
core   +2 more sources

LipoSVM: Prediction of Lysine lipoylation in Proteins based on the Support Vector Machine [PDF]

Current Genomics, 2019
Background:Lysine lipoylation which is a rare and highly conserved post-translational modification of proteins has been considered as one of the most important processes in the biological field. To obtain a comprehensive understanding of regulatory mechanism of lysine lipoylation, the key is to identify lysine lipoylated sites. The experimental methods
Wu, Meiqi, Lu, Pengchao, Yang, Yingxi, Liu, Liwen, Wang, Hui, Xu, Yan, Chu, Jixun   +6 more
openaire   +3 more sources

Redox‐dependent lipoylation of mitochondrial proteins in Plasmodium falciparum [PDF]

Molecular Microbiology, 2014
SummaryLipoate scavenging from the human host is essential for malaria parasite survival. Scavenged lipoate is covalently attached to three parasite proteins: the H‐protein and the E2 subunits of branched chain amino acid dehydrogenase (BCDH) and α‐ketoglutarate dehydrogenase (KDH). We show mitochondrial localization for the E2 subunits of BCDH and KDH,
Gustavo A, Afanador, Krista A, Matthews, David, Bartee, Jolyn E, Gisselberg, Maroya S, Walters, Caren L, Freel Meyers, Sean T, Prigge   +6 more
openaire   +2 more sources

Flashy flagella: flagellin modification is relatively common and highly versatile among the Enterobacteriaceae [PDF]

, 2016
Schematic diagrams of inserts within the fliDCAZ loci of FGI−/FMI− Enterobacteriaceae. Flanking genes are indicated by yellow arrows, predicted phage genes by blue arrows, fimbrial biogenesis genes by grey arrows and sugar/amino acid transporter genes by
Don A. Cowan, Pieter De Maayer
core   +3 more sources