Results 11 to 20 of about 3,788 (176)
Protein lipoylation: an evolutionarily conserved metabolic regulator of health and disease. [PDF]
Curr Opin Chem Biol, 2018 Lipoylation is a rare, but highly conserved lysine posttranslational modification. To date, it is known to occur on only four multimeric metabolic enzymes in mammals, yet these proteins are staples in the core metabolic landscape. The dysregulation of these mitochondrial proteins is linked to a range of human metabolic disorders.
Rowland EA, Snowden CK, Cristea IM.
europepmc +6 more sources
Protein lipoylation in mitochondria requires Fe-S cluster assembly factors NFU4 and NFU5. [PDF]
Plant Physiol, 2022 Abstract Plants have evolutionarily conserved NifU (NFU)-domain proteins that are targeted to plastids or mitochondria. “Plastid-type” NFU1, NFU2, and NFU3 in Arabidopsis (Arabidopsis thaliana) play a role in iron–sulfur (Fe–S) cluster assembly in this organelle, whereas the type-II NFU4 and NFU5 proteins have not been subjected to ...
Przybyla-Toscano J +7 more
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Genetic dissection of the mitochondrial lipoylation pathway in yeast [PDF]
BMC Biology, 2021 Background Lipoylation of 2-ketoacid dehydrogenases is essential for mitochondrial function in eukaryotes. While the basic principles of the lipoylation processes have been worked out, we still lack a thorough understanding of the details of this ...
Laura P. Pietikäinen +4 more
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Apicoplast lipoic acid protein ligase B is not essential for Plasmodium falciparum. [PDF]
PLoS Pathogens, 2007 Lipoic acid (LA) is an essential cofactor of alpha-keto acid dehydrogenase complexes (KADHs) and the glycine cleavage system. In Plasmodium, LA is attached to the KADHs by organelle-specific lipoylation pathways.
Svenja Günther +8 more
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Mitochondrial Protein Lipoylation and the 2-Oxoglutarate Dehydrogenase Complex Controls HIF1α Stability in Aerobic Conditions. [PDF]
Cell Metab, 2016 Hypoxia-inducible transcription factors (HIFs) control adaptation to low oxygen environments by activating genes involved in metabolism, angiogenesis, and redox homeostasis. The finding that HIFs are also regulated by small molecule metabolites highlights the need to understand the complexity of their cellular regulation.
Burr SP +10 more
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LipoFNT: Lipoylation Sites Identification with Flexible Neural Tree
Complexity, 2019 Lysine lipoylation is a special type of posttranslational modification in both prokaryotes’ and eukaryotes’ proteomics researches. Such a modification takes part in several significant biological processions and plays a key role in the cellular level. In
Wenzheng Bao +3 more
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The amidase domain of lipoamidase specifically inactivates lipoylated proteins in vivo.
PLoS ONE, 2009 BackgroundIn the 1950s, Reed and coworkers discovered an enzyme activity in Streptococcus faecalis (Enterococcus faecalis) extracts that inactivated the Escherichia. coli and E.
Maroya D Spalding, Sean T Prigge
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Chemical Tagging of Protein Lipoylation
Angewandte Chemie, 2020 AbstractProtein lipoylation is a post‐translational modification of emerging importance in both prokaryotes and eukaryotes. However, labeling and large‐scale profiling of protein lipoylation remain challenging. Here, we report the development of iLCL (iodoacetamide‐assisted lipoate‐cyclooctyne ligation), a chemoselective reaction that enables chemical ...
Qi Tang +3 more
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Nature Communications, 2023 Methionine restriction (MR) provides metabolic benefits in many organisms. However, mechanisms underlying the MR-induced effect remain incompletely understood. Here, we show in the budding yeast S.
Wen Fang +8 more
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Ferredoxins: master regulators in mitochondrial redox homeostasis and programmed cell death [PDF]
Redox BiologyFerredoxins (FDXs) are evolutionarily conserved iron-sulfur (Fe–S) proteins that serve as master regulators of mitochondrial redox homeostasis, governing critical processes including electron transfer, energy metabolism, Fe–S cluster biogenesis, and ...
Yajuan Lu +13 more
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