Results 41 to 50 of about 3,349,944 (177)
Ferroptosis inducers enhanced cuproptosis induced by copper ionophores in primary liver cancer
Journal of Experimental & Clinical Cancer Research, 2023 Introduction Cuproptosis and ferroptosis are the two newly defined metal-related regulated cell death. However, the crosstalk between cuproptosis and ferroptosis is obscure.
Weikai Wang +7 more
doaj +1 more source
Redox‐dependent lipoylation of mitochondrial proteins in
Molecular Microbiology, 2014 SummaryLipoate scavenging from the human host is essential for malaria parasite survival. Scavenged lipoate is covalently attached to three parasite proteins: the H‐protein and the E2 subunits of branched chain amino acid dehydrogenase (BCDH) and α‐ketoglutarate dehydrogenase (KDH). We show mitochondrial localization for the E2 subunits of BCDH and KDH,
Gustavo A, Afanador +6 more
openaire +2 more sources
Protein-Interaction Affinity Gradient Drives [4Fe–4S] Cluster Insertion in Human Lipoyl Synthase
Journal of the American Chemical Society, 2022 Human lipoyl synthase (LIAS) is an enzyme containing two [4Fe-4S] clusters (named FeSRS and FeSaux) involved in the biosynthesis of the lipoyl cofactor. The mechanism by which a [4Fe-4S] cluster is inserted into LIAS has thus far remained elusive. Here we show that NFU1 and ISCA1 of the mitochondrial iron-sulfur cluster assembly machinery, via forming ...
Saudino, Giovanni +2 more
openaire +3 more sources
Ilipo-pseaac: Identification of lipoylation sites using statistical moments and general pseaac
, 2022 Lysine Lipoylation is a protective and conserved Post Translational Modification (PTM) in proteomics research like prokaryotes and eukaryotes. It is connected with many biological processes and closely linked with many metabolic diseases.
Gillani, Durdana Qaiser +5 more
core +1 more source
CHAPTER 1.1. Disulfide Bonds in Protein Folding and Stability [PDF]
, 2018 Disulfide bonds are unique among post-translational modifications, as they add covalent crosslinks to the polypeptide chain. Accordingly, they can exert pronounced effects on protein folding and stability. This is of particular importance for secreted or
Sub Cellular Protein Chemistry +7 more
core +1 more source
Expression, Lipoylation and Structure Determination of Recombinant Pea H‐Protein in Escherichia coli [PDF]
European Journal of Biochemistry, 1996 A synthetic gene encoding the entire mature H protein of the glycine decarboxylase complex from pea (Pisum sativum L.) was constructed and expressed in Escherichia coli. The recombinant H protein, which after the induction period constituted more than half of the E. coli protein, was found in a soluble form.
D, Macherel +5 more
openaire +2 more sources
Nature Communications, 2023 Methionine restriction (MR) provides metabolic benefits in many organisms. However, mechanisms underlying the MR-induced effect remain incompletely understood. Here, we show in the budding yeast S.
Wen Fang +8 more
doaj +1 more source
Lipidomic Analysis of Plastidial Octanoyltransferase Mutants of Arabidopsis thaliana
Metabolites, 2019 Plant de novo fatty acid synthesis takes place in the plastid using acetyl-coenzyme A (acetyl-CoA) as the main precursor. This first intermediate is produced from pyruvate through the action of the plastidial pyruvate dehydrogenase complex (PDH), which ...
Raquel Martins-Noguerol +8 more
doaj +1 more source
Cuproptosis predicts the risk and clinical outcomes of lung adenocarcinoma
Frontiers in Oncology, 2022 Copper is an essential microelement for the body and a necessary coregulator for enzymatic reactions, yet an unbalanced copper level promotes reactive oxidation and cytotoxicity, which ultimately induces cell death.
Qin Hu +7 more
doaj +1 more source
Mitochondrial lipoylation integrates age-associated decline in brown fat thermogenesis [PDF]
, 2019 Thermogenesis in brown adipose tissue (BAT) declines with age; however, what regulates this process is poorly understood. Here, we identify mitochondrial lipoylation as a previously unappreciated molecular hallmark of aged BAT in mice.
Oguri, Yasuo +9 more
core +1 more source