Results 21 to 30 of about 3,788 (176)
Iron overload exaggerates renal ischemia-reperfusion injury by promoting tubular cuproptosis via interrupting function of LIAS [PDF]
Redox BiologyRenal ischemia-reperfusion injury (RIRI), a major contributor to acute kidney injury (AKI) and delayed graft function (DGF), is closely associated with dysregulation of metal ion homeostasis.
Siyue Chen +6 more
doaj +2 more sources
mBio, 2018 Lipoate is a redox active cofactor that is covalently bound to key enzymes of oxidative metabolism. Plasmodium falciparum is auxotrophic for lipoate during the intraerythrocytic stages, but it is not known whether lipoate attachment to protein is ...
Hugo Jhun +2 more
doaj +2 more sources
CoA‐dependent activation of mitochondrial acyl carrier protein links four neurodegenerative diseases [PDF]
EMBO Molecular Medicine, 2019 PKAN, CoPAN, MePAN, and PDH‐E2 deficiency share key phenotypic features but harbor defects in distinct metabolic processes. Selective damage to the globus pallidus occurs in these genetic neurodegenerative diseases, which arise from defects in CoA ...
Roald A Lambrechts +10 more
doaj +3 more sources
Chemical Probes Reveal Sirt2’s New Function as a Robust “Eraser” of Lysine Lipoylation
, 2019 Lysine lipoylation, a highly conserved lysine post-translational modification, plays a critical role in regulating cell metabolism. The catalytic activity of a number of vital metabolic proteins, such as pyruvate dehydrogenase (PDH), depends on lysine ...
Hongyan Sun (327879) +10 more
core +6 more sources
Frontiers in Medicine, 2022 Recent studies have found that the protein encoded by the FDX1 gene is involved in mediating Cuproptosis as a regulator of protein lipoylation and related to immune response process of tumors.
Hanwen Lu +12 more
doaj +1 more source
Evidence for two protein‐lipoylation activities in Escherichia coli [PDF]
FEBS Letters, 1991 The lipoate acyltransferase subunits of the 2‐oxo acid dehydrogenase complexes are post‐translationally modified with one or more covalently‐bound lipoyl cofactors. Two distinct lipoate‐protein ligase activities, LPL‐A and LPL‐B, have been detected in E. coli by their ability to modify purified lipoyl apo‐domains of the bacterial pyruvate dehydrogenase
Brookfield, Dawn E. +4 more
openaire +2 more sources
Chemoselective and laser cleavable probes for <i>in situ</i> protein lipoylation detection by laser desorption/ionization mass spectrometry. [PDF]
Chem SciChemoselective probe is connected with gold nanoparticles modified with laser cleavable mass tags by click chemistry for in situ protein lipoylation detection by laser desorption/ionization mass spectrometry.
Du Q +8 more
europepmc +3 more sources
Lipoylation Mechanism of P. Falciparum Mitochondrial Proteins [PDF]
Biophysical Journal, 2015 Lipoate is an essential cofactor for the aerobic metabolism in oxidative decarboxylation reactions of 2-oxoacid complexes. Malaria parasite survival is highly dependent on scavenging this essential cofactor from the human host. Scavenged lipoate is subsequently attached to the α-ketoglutarate dehydrogenase (KDH), the branched chain α-ketoacid ...
Guerra, Alfredo J. +3 more
openaire +1 more source
Frontiers in Chemistry, 2021 Lipoic acid (LA) is an organic compound that plays a key role in cellular metabolism. It participates in a posttranslational modification (PTM) named lipoylation, an event that is highly conserved and that occurs in multimeric metabolic enzymes of very ...
Sun Liu Rei Yan +4 more
doaj +1 more source
Lipoate-Protein Ligase and Octanoyltransferase Are Essential for Protein Lipoylation in Mitochondria of Arabidopsis [PDF]
Plant Physiology, 2014 AbstractProsthetic lipoyl groups are required for the function of several essential multienzyme complexes, such as pyruvate dehydrogenase (PDH), α-ketoglutarate dehydrogenase (KGDH), and the glycine cleavage system (glycine decarboxylase [GDC]). How these proteins are lipoylated has been extensively studied in prokaryotes and yeast (Saccharomyces ...
Ralph, Ewald +5 more
openaire +2 more sources