Results 51 to 60 of about 4,093 (168)

NADH‐Reductive Stress Induced by Dihydrolipoamide Dehydrogenase Activation Contributes to Cuproptosis

Advanced Science, Volume 13, Issue 9, 13 February 2026.
This study demonstrates a cuproptosis mechanism involving nicotinamide adenine dinucleotide (NADH)‐reductive stress in neural cells. Copper activates dihydrolipoamide dehydrogenase under mitochondrial pH, accumulating NADH. Copper also induces mitochondrial permeability transition pore opening, facilitating NADH translocation to the cytosol and ...
Si‐Yi Zhang, Xing‐Hua Ren, Cheng‐Hong Zhang, Zhan‐You Wang   +3 more
wiley   +1 more source

CoA-dependent activation of mitochondrial acyl carrier protein links four neurodegenerative diseases [PDF]

, 2019
PKAN, CoPAN, MePAN, and PDH-E2 deficiency share key phenotypic features but harbor defects in distinct metabolic processes. Selective damage to the globus pallidus occurs in these genetic neurodegenerative diseases, which arise from defects in CoA ...
Autio, Kaija J, Bakker, Barbara M, Grzeschik, Nicola A, Hayflick, Susan J, Lambrechts, Roald A, Schepers, Hein, Sibon, Ody Cm, Tijssen, Marina A, van der Zwaag, Marianne, Vieira-Lara, Marcel A, Yu, Yi   +10 more
core   +2 more sources

Diversity of FAAL enzymes and prediction of their substrate specificity using FAALPred

Protein Science, Volume 35, Issue 2, February 2026.
Abstract FAALs (fatty acyl‐AMP ligases) recruit and incorporate fatty acids during the biosynthesis of secondary metabolites. Their diversity, distribution, and substrate specificity remain poorly understood, which limits functional predictions from sequence data.
Anne Liong, Leandro de Mattos Pereira, Pedro N. Leão   +2 more
wiley   +1 more source

Ohr (Organic Hydroperoxide Resistance Protein) Possesses a Previously Undescribed Activity, Lipoyl-dependent Peroxidase [PDF]

Journal of Biological Chemistry, 2010
The Ohr (organic hydroperoxide resistance) family of 15-kDa Cys-based, thiol-dependent peroxidases is central to the bacterial response to stress induced by organic hydroperoxides but not by hydrogen peroxide. Ohr has a unique three-dimensional structure and requires dithiols, but not monothiols, to support its activity.
José R R, Cussiol, Thiago G P, Alegria, Luke I, Szweda, Luis E S, Netto   +3 more
openaire   +2 more sources

Boosting Cuproptosis in Breast Cancer Therapy via Photodynamic Treatment With a New Liposome

FASEB BioAdvances, Volume 8, Issue 2, February 2026.
ABSTRACT Breast cancer (BC) is one of the most common cancers in women around the world, and utilizing a combined approach is a crucial strategy. Induction of cuproptosis in tumor cells is a novel antitumor approach, though its standalone efficacy remains unclear.
Jie Yu, Ning Sun, Limei You, Jialing Liu, Mengna Niu, Jiacheng Shi, Weixin Chen, Futong Li, Shengbao Wang, Jiaqi Liu   +9 more
wiley   +1 more source

Chirality‐Directed Strategy to Overcome Tumor Resistance to Cuproptosis and Enhance Cuproptosis‐Immunotherapy

Small Structures, Volume 7, Issue 1, January 2026.
Chirality‐directed strategy designed by copper‐based nanoregulator (Cu‐D‐Car@HA) to potentiate collaborative cuproptosis‐immunotherapy by overcoming tumor resistance to cuproptosis highlights a materials‐based method for superior cuproptosis‐immunotherapy.
Hao Zhou, Xiaoyang Zhang, Yu‐Zhang Wang, Shi‐Man Zhang, Hong Chen, Xiao Yan, Chi‐Hui Yang, Wei‐Hai Chen, Xian‐Zheng Zhang   +8 more
wiley   +1 more source

Progress of Programmed Cell Death in Steroid‐Induced Osteonecrosis of the Femoral Head

Orthopaedic Surgery, Volume 18, Issue 1, Page 16-30, January 2026.
Steroid‐induced osteonecrosis of the femoral head is a severe osteoarticular condition resulting from glucocorticoid overuse, characterized by femoral head bone structure collapse and cell death, now predominant among nontraumatic femoral head necroses.
Zhi Kong, Chao Han
wiley   +1 more source

Lipidomic Analysis of Plastidial Octanoyltransferase Mutants of Arabidopsis thaliana [PDF]

, 2019
International audiencePlant de novo fatty acid synthesis takes place in the plastid using acetyl-coenzyme A (acetyl-CoA) as the main precursor. This first intermediate is produced from pyruvate through the action of the plastidial pyruvate dehydrogenase ...
Acket, Sébastien, Garcés, Rafael, Makni, Salim, Martins-Noguerol, Raquel, Martínez-Force, Enrique, Moreno-Pérez, Antonio,, Salas, Joaquín,, Thomasset, Brigitte, Troncoso-Ponce, Adrián   +8 more
core   +3 more sources

Mitochondrial Fatty Acids and Neurodegenerative Disorders [PDF]

, 2020
Fatty acids in mitochondria, in sensu stricto, arise either as β-oxidation substrates imported via the carnitine shuttle or through de novo synthesis by the mitochondrial fatty acid synthesis (mtFAS) pathway. Defects in mtFAS or processes involved in the
Autio, Kaija J., Kastaniotis, Alexander J., Nair, Remya R.   +2 more
core   +1 more source

Cuproptosis at the Crossroads of Tumor Microenvironment Inflammation and Metabolic Rewiring Mechanisms and Therapeutic Opportunities

Mediators of Inflammation, Volume 2026, Issue 1, 2026.
Metabolic reorganization and chronic inflammation are dynamic and diverse events in the tumor microenvironment (TME) that cause tumor propagation, spreading, and resistance to treatment. However, copper‐induced cell death (cuproptosis), which is a newly discovered form of regulated cell death (RCD) induced by high intracellular copper ions and is a ...
Yan Wang, Yunfei Zhu, Yanxin Wang, Yutong Liu, Pengfei Wang, Mingkun Yu, Hengrui Liu   +6 more
wiley   +1 more source