Results 61 to 70 of about 4,093 (168)

Different opinion on the reported role of Poldip2 and ACSM1 in a mammalian lipoic acid salvage pathway controlling HIF-1 activation. [PDF]

, 2018
Paredes et al recently described Poldip2 as a novel regulator of mitochondrial lipoylation through stabilisation of ACSM1 (1). We have several concerns with their proposed model based on the following reasons.Wellcome 102770/Z/13/Z and 205252/Z/16/Z ...
Bailey, Peter SJ, Dieckmann, Carol L, Hiltunen, J Kalervo, Kastaniotis, Alexander J, Nathan, James A   +4 more
core   +1 more source

Mendelian Randomization Identified SLC2A9 as a Novel cis‐eQTL‐Mediated Susceptibility Gene in Suppressing Renal Cancer and Its Related Metabolic Mechanisms

Mediators of Inflammation, Volume 2026, Issue 1, 2026.
Objective Mendelian randomization (MR) analysis has currently been widely used in combination with expression quantitative trait loci (eQTLs) or cis‐eQTLs for identifying novel drug targets in various diseases. Hence in this article, we first integrated MR analysis with eQTLs and cis‐eQTLs to reveal the causal effects among SLC2A9 and renal cancer (RC),
Yi Wang, Yu Song, Hao Ji, Bingye Zhu, Huyang Xie, Fumio Tsuji   +5 more
wiley   +1 more source

Navigating Transition Metal‐Dependent Cell Death: Mechanisms, Crosstalk, and Future Directions

Advanced Science, Volume 12, Issue 46, December 11, 2025.
Transition metals trigger distinct regulated cell death pathways beyond traditional apoptosis. This review examines ferroptosis (iron‐catalyzed lipid peroxidation) and cuproptosis (copper‐induced mitochondrial proteotoxicity), while exploring hypothetical “cobaltosis” as a novel pathway.
Qinghang Song, Yuxuan Yang, Lina Yang
wiley   +1 more source

Lipoate Metabolism in Staphylococcus Aureus Pathogenesis [PDF]

, 2016
Lipoate is an essential cofactor of several proteins involved in cellular energy homeostasis and catabolism. Lipoate metabolism has been linked to pathogenesis in some microbial species, but its role in Staphylococcus aureus infections had not been ...
Zorzoli, Maria Azul
core   +1 more source

Radiation‐Induced Biological Effects: Molecular and Cellular Mechanism, and Applications to Radiation/Nuclear Emergency and Cancer Therapy

MedComm, Volume 6, Issue 12, December 2025.
Radiation‐induced biological effects are an extremely complex and extensive mechanism that involves multiple aspects of physiological activities in organisms. In the medical field, utilizing the damaging effects of radiation to treat tumors is a commonly employed therapeutic approach.
Zhihe Hu, Yan Chen, Shengyi Yang, Shihai Diao, Le Ma, Chunmeng Shi   +5 more
wiley   +1 more source

A Herbal‐Piezoelectric Heterojunction Strategy to Potentiate Bacterial Cuproptosis‐Like Death and Remodel the Inflammatory Microenvironment in Infection‐Associated Implant Osteomyelitis

Advanced Science, Volume 12, Issue 43, November 20, 2025.
A titanium implant coating integrating berberine and copper‐doped strontium titanate leverages ultrasound to compromise bacterial membranes and induce cuproptosis‐like death. This approach resolves S. aureus infections in osteomyelitis models while suppressing inflammation and promoting osseointegration, demonstrating a dual‐functional strategy against
Guannan Zhang, Zehao Li, Ying Lu, Jianbo Song, Xingyu Liang, Peide Han, Xiaohong Yao, Yongqiang Yang, Xiangyu Zhang   +8 more
wiley   +1 more source

Mechanism and role of regulated cell death in tumor immunity and immunotherapy

Cancer Communications, Volume 45, Issue 11, Page 1456-1495, November 2025.
Abstract Cancer immune checkpoint inhibitors (ICIs) have brought breakthroughs, but only about one‐third of cancer patients benefit from ICIs. In recent years, targeting non‐apoptotic regulated cell death (RCD) subtypes, such as ferroptosis, necroptosis, autophagy, cuproptosis, and pyroptosis, has emerged as a novel strategy in cancer therapy due to ...
Jingwen Hu, Yan Li, Bingjie Lian, Yitao Mao, Luqing Zhao   +4 more
wiley   +1 more source

Lipoic acid protein ligases in Plasmodium spp. [PDF]

, 2008
Protozoan parasites of the genus Plasmodium are the causative agent of malaria. The four human pathogenic species infect more than 500 million people each year, causing the death of at least 1 million people.
Günther, Svenja
core   +1 more source

SNHG26 Promotes Colorectal Cancer Progression via CDKN2A‐Dependent Regulation of Cuproptosis and CD8+ T Cell‐Mediated Immunity

Journal of Cellular and Molecular Medicine, Volume 29, Issue 22, November 2025.
ABSTRACT Long non‐coding RNAs (lncRNAs) play important roles in colorectal cancer (CRC) progression. However, the biological function and regulatory mechanism of small nucleolar RNA host gene 26 (SNHG26) in CRC remain largely unexplored. SNHG26 expression was analysed in CRC tissues and cell lines using quantitative real‐time PCR (qRT‐PCR).
Ziang Wan, Shan Gao
wiley   +1 more source

Mitochondrial acyl carrier protein (ACP) at the interface of metabolic state sensing and mitochondrial function [PDF]

, 2019
Acyl carrier protein (ACP) is a principal partner in the cytosolic and mitochondrial fatty acid synthesis (FAS) pathways. The active form holo-ACP serves as FAS platform, using its 4′-phosphopantetheine group to present covalently attached FAS ...
Autio, Kaija J., Hiltunen, J. Kalervo, Kastaniotis, Alexander J., Masud, Ali J., Rahman, M. Tanvir   +4 more
core   +1 more source