Results 41 to 50 of about 30,111 (219)

Membrane-associated proteins in giardia lamblia [PDF]

, 2018
The manner in which membrane-associated proteins interact with the membrane defines their subcellular fate and function. This interaction relies on the characteristics of the proteins, their journey after synthesis, and their interaction with other ...
Feliziani, Constanza, Ropolo, Andrea Silvana, Touz, Maria Carolina   +2 more
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Palmitoylation of virus proteins [PDF]

Biology of the Cell, 2012
AbstractThe article summarises the results of more than 30 years of research on palmitoylation (S‐acylation) of viral proteins, the post‐translational attachment of fatty acids to cysteine residues of integral and peripheral membrane proteins. Analysing viral proteins is not only important to characterise the cellular pathogens but also instrumental to
openaire   +2 more sources

Novel components of the Toxoplasma inner membrane complex revealed by BioID. [PDF]

, 2015
UNLABELLED:The inner membrane complex (IMC) of Toxoplasma gondii is a peripheral membrane system that is composed of flattened alveolar sacs that underlie the plasma membrane, coupled to a supporting cytoskeletal network. The IMC plays important roles in
Bell, Hannah N, Bentolila, Laurent A, Bradley, Peter J, Chen, Allan L, Huang, Amy S, Kim, Elliot W, Moon, Andy S, Rashoff, Andrew Q, Toh, Justin Y, Van, Christina, Vashisht, Ajay A, Wohlschlegel, James A   +11 more
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Selenoprotein K and Protein Palmitoylation [PDF]

Antioxidants & Redox Signaling, 2015
Selenoprotein K (SelK) is an endoplasmic reticulum (ER) membrane protein, and its expression is sensitive to dietary selenium levels. A recently described role for SelK as a cofactor in catalyzing protein palmitoylation reactions provides an important link between low dietary selenium intake and suboptimal cellular functions that depend on this ...
Gregory J, Fredericks, Peter R, Hoffmann
openaire   +2 more sources

ER-Mitochondria contact sites : a new regulator of cellular calcium flux comes into play [PDF]

, 2016
Endoplasmic reticulum (ER)-mitochondria membrane contacts are hotspots for calcium signaling. In this issue, Raturi et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201512077) show that the thioredoxin TMX1 inhibits the calcium pump SERCA2b at ...
Anelli, Appenzeller-Herzog, Bittremieux, Booth, Csordás, Cárdenas, Cárdenas, Doghman-Bouguerra, Geert Bultynck, Hayashi, Higo, Krols, Li, Lynes, Lynes, Marchi, Marino, Michiel Krols, Raturi, Rizzuto, Roderick, Sophie Janssens, Szabadkai   +22 more
core   +2 more sources

PalmPred: an SVM based palmitoylation prediction method using sequence profile information.

PLoS ONE, 2014
Protein palmitoylation is the covalent attachment of the 16-carbon fatty acid palmitate to a cysteine residue. It is the most common acylation of protein and occurs only in eukaryotes.
Bandana Kumari, Ravindra Kumar, Manish Kumar   +2 more
doaj   +1 more source

Attenuated palmitoylation of serotonin receptor 5-HT1A affects receptor function and contributes to depression-like behaviors [PDF]

, 2019
The serotonergic system and in particular serotonin 1A receptor (5-HT1AR) are implicated in major depressive disorder (MDD). Here we demonstrated that 5-HT1AR is palmitoylated in human and rodent brains, and identified ZDHHC21 as a major palmitoyl ...
Bazovkina, Daria, Bijata, Monika, Galil, Dalia Abdel, Gorinski, Nataliya, Kondaurova, Elena, Kulikova, Elizabeth [u.v.m.], Prasad, Sonal, Sigrist, Stephan, Wirth, Alexander, Zeug, Andre   +9 more
core   +1 more source

Palmitoylated proteins: purification and identification [PDF]

Nature Protocols, 2007
This proteomic protocol purifies and identifies palmitoylated proteins (i.e., S-acylated proteins) from complex protein extracts. The method relies on an acyl-biotinyl exchange chemistry in which biotin moieties are substituted for the thioester-linked protein acyl-modifications through a sequence of three in vitro chemical steps: (i) blockade of free ...
Junmei, Wan, Amy F, Roth, Aaron O, Bailey, Nicholas G, Davis   +3 more
openaire   +2 more sources

Mechanisms and functional implications of ZDHHC5 in cellular physiology and disease

Journal of Lipid Research
Post-translational lipid modification by palmitoylation is a reversible process crucial for maintaining cellular functionality. The palmitoyl acyltransferase zinc finger Asp-His-His-Cys motif-containing 5 (ZDHHC5) has garnered significant attention due ...
Huicong Liu, Shuo Wen, Chang Xu, Xiaohong Kang, Eryan Kong   +4 more
doaj   +1 more source

Understanding the process of envelope glycoprotein incorporation into virions in simian and feline immunodeficiency viruses [PDF]

, 2014
The lentiviral envelope glycoproteins (Env) mediate virus entry by interacting with specific receptors present at the cell surface, thereby determining viral tropism and pathogenesis.
Affranchino, Jose Luis, Gonzalez, Silvia Adriana   +1 more
core   +4 more sources