Results 71 to 80 of about 30,111 (219)

Protein S-palmitoylation regulates different stages of meiosis in Schizosaccharomyces pombe

Life Science Alliance, 2023
The vital role of S-palmitoylation in cell differentiation is demonstrated in the fission yeast by showing that the modification is required at multiple meiotic stages including mating and karyogamy.
Thanh-Vy Pham, Wan-Yi Hsiao, Yi-Ting Wang, Shu-Dan Yeh, Shao-Win Wang   +4 more
doaj   +1 more source

Amino acid residues 24-31 but not palmitoylation of cysteines 30 and 45 are required for membrane anchoring of glutamic acid decarboxylase, GAD65. [PDF]

, 1994
The smaller isoform of the GABA synthesizing enzyme glutamic acid decarboxylase, GAD65, is synthesized as a soluble protein that undergoes post-translational modification(s) in the NH2-terminal region to become anchored to the membrane of small synaptic ...
Baekkeskov, Steinunn, Shi, Y, Veit, B
core  

Examining the role of insulin in the regulation of cardiovascular health [PDF]

, 2013
A substantial body of evidence has reported that insulin has direct actions on the cardiovascular system independent of its systemic effects on plasma glucose or lipids.
Salt, Ian P.
core   +1 more source

Dual Covalent Targeting of STING Cysteines 292/309 Disrupts Functional Oligomerization and Enables Potent Antagonist Development

Advanced Science, EarlyView.
We report a rational design strategy for STING antagonists by dual covalent targeting of Cys292/309 in its C‐terminal domain, directly preventing functional oligomerization. Through covalent warhead repurposing, we identified P005091 and revealed its unique dual‐cysteine mechanism.
Yuxuan Zhao, Ling Huang, Wenjing Qin, Bin Zhang, Yang Yang, Xue Chen, Xiaoquan Wang, Weilin Zhou, Feiyang Chen, Zhenyu Li, Liyuan Le, Yiqiu Zhang, Zhen Xiang, Lu Zhang, Fei Wang, Dan Lei, Zi‐zhe Cai, Ying Gao, Yong Chen, Xuecen Wang, Junmin Quan, Shuixing Zhang, Xianzhang Bu, Xin Yue   +23 more
wiley   +1 more source

ZDHHC11 Suppresses Zika Virus Infections by Palmitoylating the Envelope Protein

Viruses, 2023
Zika virus (ZIKV) is an RNA-enveloped virus that belongs to the Flavivirus genus, and ZIKV infections potentially induce severe neurodegenerative diseases and impair male fertility.
Dingwen Hu, Haimei Zou, Weijie Chen, Yuting Li, Ziqing Luo, Xianyang Wang, Dekuan Guo, Yu Meng, Feng Liao, Wenbiao Wang, Ying Zhu, Jianguo Wu, Geng Li   +12 more
doaj   +1 more source

Chimeric glutamate receptor subunits reveal the transmembrane domain is sufficient for NMDA receptor pore properties but some positive allosteric modulators require additional domains [PDF]

, 2016
NMDA receptors are ligand-gated ion channels that underlie transmission at excitatory synapses and play an important role in regulating synaptic strength and stability.
Huettner, Jmaes E, Lopez, Melany N, Wilding, Timothy J   +2 more
core   +2 more sources

ESCRT‐Mimetic Nanodegrader Targets STING for Anti‐Inflammatory Therapy

Advanced Science, EarlyView.
A nanoplatform‐enabled targeted protein degradation strategy is presented to regulate aberrant STING signaling. STING‐ATTEC induces selective autophagic degradation of STING via formation of a STING–ATTEC–LC3 ternary complex, while the cationic FA‐LNP+ system enhances LC3 generation and targeted delivery. Together, this synergistic approach efficiently
Fuyuan Zhou, Qiming Zhai, Zhihao Yao, Qing Li, Yan Yang, Si Wang, Chao Huang, Liangjing Xin, Tao Chen, Jinlin Song   +9 more
wiley   +1 more source

The CP123L protein of African swine fever virus is a membrane-associated, palmitoylated protein required for viral replication

Journal of Virology
African swine fever (ASF) is a highly contagious and often lethal disease caused by African swine fever virus (ASFV) in pigs. Protein palmitoylation is a prevalent posttranslational lipid modification that can modulate viral replication.
Xiangyu Guan, Tao Wang, Yuxuan Gao, Huanjie Zhai, Fengwei Jiang, Qinghe Hou, Xiaoke Yang, Hongxia Wu, Lian-Feng Li, Yuzi Luo, Su Li, Yuan Sun, Hua-Ji Qiu, Yongfeng Li   +13 more
doaj   +1 more source

Effect of C-Terminal S-Palmitoylation on D2 Dopamine Receptor Trafficking and Stability. [PDF]

PLoS ONE, 2015
We have used bioorthogonal click chemistry (BCC), a sensitive non-isotopic labeling method, to analyze the palmitoylation status of the D2 dopamine receptor (D2R), a G protein-coupled receptor (GPCR) crucial for regulation of processes such as mood ...
Brittany Ebersole, Jessica Petko, Matthew Woll, Shoko Murakami, Kate Sokolina, Victoria Wong, Igor Stagljar, Bernhard Lüscher, Robert Levenson   +8 more
doaj   +1 more source

PRDX6: A protein bridging S-palmitoylation and diabetic neuropathy

Frontiers in Endocrinology, 2022
Diabetic neuropathy is regarded as one of the most debilitating outcomes of diabetes. It can affect both the peripheral and central nervous systems, leading to pain, decreased motility, cognitive decline, and dementia.
Yan Cao, Wantao Wang, Xiaorong Zhan, Yitong Zhang   +3 more
doaj   +1 more source