Protein Prenylation in Plant Stress Responses [PDF]
Molecules, 2019 Protein prenylation is one of the most important posttranslational modifications of proteins. Prenylated proteins play important roles in different developmental processes as well as stress responses in plants as the addition of hydrophobic prenyl chains
Michal Hála, Viktor Žárský
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Protein Prenylation and Hsp40 in Thermotolerance of Plasmodium falciparum Malaria Parasites [PDF]
mBio, 2021 During its complex life cycle, the malaria parasite survives dramatic environmental stresses, including large temperature shifts.
Emily S. Mathews +2 more
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Protein Prenylation in Plants: Mechanisms and Functional Implications [PDF]
PlantsProtein prenylation is a crucial post-translational modification that involves the formation of a covalent bond between isoprenoid lipids and the cysteine residues of specific proteins.
Chang Tian, Quan Wang
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Updates on protein-prenylation and associated inherited retinopathies [PDF]
Frontiers in OphthalmologyMembrane-anchored proteins play critical roles in cell signaling, cellular architecture, and membrane biology. Hydrophilic proteins are post-translationally modified by a diverse range of lipid molecules such as phospholipids ...
Sudhat Ashok +3 more
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Uncovering protein prenylation in Th1 cells: novel prenylation sites and insights into statin and farnesyltransferase inhibition [PDF]
BMC BiologyBackground T helper 1 (Th1) cell activation is an essential process for immune responses and is tightly regulated, including the prenylation of proteins critical for T cell function.
Jana Koch +9 more
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Compromised Protein Prenylation as Pathogenic Mechanism in Mevalonate Kinase Deficiency [PDF]
Frontiers in Immunology, 2021 Mevalonate kinase deficiency (MKD) is an autoinflammatory metabolic disorder characterized by life-long recurring episodes of fever and inflammation, often without clear cause. MKD is caused by bi-allelic pathogenic variants in the MVK gene, resulting in
Frouwkje A. Politiek, Hans R. Waterham
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Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions [PDF]
Nature Communications, 2019 Macrophage specific deletion of GGTase-I, a prenylation enzyme, in mice induces inflammatory response and rheumatoid arthritis. Here the authors show that GGTase-I deficiency and the resulting reduction of RAC1 prenylation increase RAC1 interaction with ...
Murali K. Akula +13 more
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Defective Protein Prenylation in a Spectrum of Patients With Mevalonate Kinase Deficiency [PDF]
Frontiers in Immunology, 2019 The rare autoinflammatory disease mevalonate kinase deficiency (MKD, which includes HIDS and mevalonic aciduria) is caused by recessive, pathogenic variants in the MVK gene encoding mevalonate kinase.
Marcia A. Munoz +10 more
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Targeting protein prenylation in progeria. [PDF]
Sci Transl Med, 2013 Results of a recent clinical trial in children with Hutchinson-Gilford progeria spur scientists to consider new therapeutic strategies.
Young SG +4 more
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Towards the systematic mapping and engineering of the protein prenylation machinery in Saccharomyces cerevisiae. [PDF]
PLoS ONE, 2015 Protein prenylation is a widespread and highly conserved eukaryotic post-translational modification that endows proteins with the ability to reversibly attach to intracellular membranes.
Viktor Stein +4 more
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