Results 121 to 130 of about 32,326 (169)

Antigenic Prenylated Peptide Conjugates and Polyclonal Antibodies To Detect Protein Prenylation

Bioconjugate Chemistry, 2004
Posttranslational modification of proteins with farnesyl and geranylgeranyl groups is a required modification for signaling proteins that includes the small GTPases in the Ras, Rho, and Rab families, heterotrimeric G proteins, and nuclear lamin proteins.
Xiao-hui, Liu, Dae-Yeon, Suh, Jeffrey, Call, Glenn D, Prestwich   +3 more
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Prenylation and G Protein Signaling

1994
Publisher Summary This chapter presents recent studies in the field of protein prenylation, with particular emphasis on the enzymology of these processes and the influence of the modifications on specific G proteins involved in cellular signaling. The known prenylated proteins include a number of GTP-binding regulatory proteins (G proteins); these ...
P J, Casey, J F, Moomaw, F L, Zhang, Y B, Higgins, J A, Thissen   +4 more
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Prenylation of proteins in Trypanosoma brucei

Molecular and Biochemical Parasitology, 1997
Prenyl modification of proteins by farnesyl and geranylgeranyl isoprenoids occurs in a variety of eukaryotic cells. Culturing of Trypanosoma brucei in the presence of [3H]mevalonolactone (which is hydrolyzed in cells to give mevalonic acid, the precursor of protein prenyl groups) and an inhibitor of mevalonic acid biosynthesis leads to the ...
K, Yokoyama, Y, Lin, K D, Stuart, M H, Gelb   +3 more
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Prenylated Proteins in Regenerating Rat Liver

Biochemical and Biophysical Research Communications, 1994
During rat liver regeneration, at the onset of S-phase of the first cell cycle, an enhanced mevalonate incorporation into prenylated proteins is observed. The analysis of the lipid moieties of such proteins shows a 20-fold increased content of geraniol and farnesol. The expected increase of farnesylated and geranylgeranylated proteins in pre-S phase is
G, Bruscalupi, F, Castellano, S, Sacco, A, Trentalance   +3 more
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Non-peptidic, non-prenylic inhibitors of the prenyl protein-specific protease Rce1

Bioorganic & Medicinal Chemistry Letters, 2001
Several compounds designed as bisubstrate analogues of protein farnesyltransferase inhibited the prenyl protein-specific protease Rce1, qualifying them as lead structures for a novel class of non-peptidic, non-prenylic inhibitors of this protease.
M, Schlitzer, A, Winter-Vann, P J, Casey
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Protein Prenylation in Tetrahymena

Archiv für Protistenkunde, 1996
Summary Tetrahymena vorax V 2S and Tetrahymena pyriformis GL were examined for the presence of proteins covalently modified with mevalonate-derived lipids. Radiolabeling of cells using [3H]mevalonolactone, [ 3 H]mevalonate, [ 3 H]farnesyl pyrophosphate or [ 3 H]geranylgeranyl pyrophosphate resulted in the appearance of protein-associated ...
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REP-Mediated Protein Prenylation

1998
Addition of isoprenoids to polypeptides is a common post-translational modification occurring in yeast, animal and plant cells. Isoprenoid precursors are derived from the mevalonate pathway and are incorporated into many cellular products such as sterols, heme A, ubiquinone, dolichols, carotenoids and prenylated proteins (Goldstein and Brown, 1990).
U. Bialek, B. E. Bauer, M. Miaczynska, S. Lorenzetti, R. J. Schweyen, A. Ragnini   +5 more
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Isopentenoid synthesis in embryonic Drosophila cells: Prenylated protein profile and prenyl group usage

Archives of Biochemistry and Biophysics, 1992
It has been established that vertebrates and yeasts modified a unique subset of polypeptides with farnesyl and geranylgeranyl residues. This observation has been extended to Drosophila Kc cells. [3H]Mevalonate was incorporated into 54 Kc cell peptides (18-92 kDa).
C M, Havel, P, Fisher, J A, Watson
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PROTEIN PRENYLATION: GENES, ENZYMES, TARGETS, AND FUNCTIONS

Annual Review of Genetics, 1992
PROTEINS INVOLVED IN PRENYL-DEPENDENT PROCESSING 217 Protein Prenyltransferases 218 Proteases 221 Reversible Modifications 223 PRENYL-MEDIATED INTERACTIONS 225 Prenyl-protein Receptors 225 Lipid Interactions 227 Indirect Prenyl-dependent Targeting ...
W R, Schafer, J, Rine
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Inhibitors of protein prenylation 1999

Expert Opinion on Therapeutic Patents, 1999
Interest in farnesyltransferase inhibitors (FTIs) as a potential cancer therapy continues, judging from the approximately eighty patent applications published in the fourteen month period from January 1998. This review summarises progress in the field since the previous update [1] and includes a description of the first clinical trials in man.
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