Results 31 to 40 of about 32,326 (169)
Molecular Therapy: Methods & Clinical Development, 2018 Choroideremia (CHM) is a rare, X-linked recessive retinal dystrophy caused by mutations in the CHM gene. CHM is ubiquitously expressed in human cells and encodes Rab escort protein 1 (REP1).
Maria I. Patrício +4 more
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Prenylated Rab Acceptor Protein Is a Receptor for Prenylated Small GTPases [PDF]
Journal of Biological Chemistry, 2001 Localization of Ras and Ras-like proteins to the correct subcellular compartment is essential for these proteins to mediate their biological effects. Many members of the Ras superfamily (Ha-Ras, N-Ras, TC21, and RhoA) are prenylated in the cytoplasm and then transit through the endomembrane system on their way to the plasma membrane.
C, Figueroa, J, Taylor, A B, Vojtek
openaire +2 more sources
Multiple domain insertions and losses in the evolution of the Rab prenylation complex
BMC Evolutionary Biology, 2007 Background Rab proteins are regulators of vesicular trafficking, requiring a lipid modification for proper function, prenylation of C-terminal cysteines.
Pereira-Leal Jose B, Rasteiro Rita
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Platelets, 2023 Statins inhibit the mevalonate pathway by impairing protein prenylation via depletion of lipid geranylgeranyl diphosphate (GGPP). Rab27b and Rap1a are small GTPase proteins involved in dense granule secretion, platelet activation, and regulation.
Mohammed M Jalal +3 more
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Frontiers in Neuroscience, 2019 Thirty years after the first description and modeling of G protein coupled receptors (GPCRs), information about their mode of action is still limited. One of the questions that is hard to answer is: how do the allosteric changes in the GPCR induced by, e.
Arnold De Loof, Liliane Schoofs
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Beyond the Mevalonate Pathway: Control of Post-Prenylation Processing by Mutant p53
Frontiers in Oncology, 2020 Missense mutations in the TP53 gene are among the most frequent alterations in human cancer. Consequently, many tumors show high expression of p53 point mutants, which may acquire novel activities that contribute to develop aggressive tumors.
Carla M Borini Etichetti +3 more
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Towards complete sets of farnesylated and geranylgeranylated proteins. [PDF]
PLoS Computational Biology, 2007 Three different prenyltransferases attach isoprenyl anchors to C-terminal motifs in substrate proteins. These lipid anchors serve for membrane attachment or protein-protein interactions in many pathways.
Sebastian Maurer-Stroh +5 more
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Scientific Reports, 2021 Protein prenylation involves the attachment of one or two isoprenoid group(s) onto cysteine residues positioned near the C-terminus. This modification is essential for many signal transduction processes.
Kiall F. Suazo +6 more
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Phosphatase of regenerating liver-3 localizes to cyto-membrane and is required for B16F1 melanoma cell metastasis in vitro and in vivo. [PDF]
PLoS ONE, 2009 BACKGROUND: Phosphatase of regenerating liver-3 (PRL-3) is a member of the novel phosphatases of regenerating liver family, characterized by one protein tyrosine phosphatase active domain and a C-terminal prenylation (CCVM) motif.
Ran Song +5 more
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mBio, 2023 In the apicomplexans, endocytosed cargos (e.g., hemoglobin) are trafficked to a specialized organelle for digestion. This follows a unique endocytotic process at the micropore/cytostome in these parasites.
Qiang-Qiang Wang +16 more
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