Results 71 to 80 of about 32,326 (169)

Are Muscular Dystrophies Cholesterol‐Handling Diseases? Lessons From HMGCR Variants and Statin‐Associated Myopathies

JCSM Communications, Volume 9, Issue 1, January/June 2026.
ABSTRACT Background Muscular dystrophies (MD) are a genetically diverse group of muscle disorders, many of which arise from mutations in genes encoding components of the sarcolemma dystrophin‐associated glycoprotein complex (DGC). Despite their notorious heterogeneity, MDs consistently lead to chronic myofiber weakening, necrosis and loss of muscle ...
Yejin Kang, Pascal Bernatchez
wiley   +1 more source

Reversible Binding and Trafficking of DNA Origami Between Lipid Membrane Phases

Small Structures, Volume 7, Issue 1, January 2026.
A DNA origami nanostructure was functionalized with different lipophilic anchor types. Depending on the anchor type, these nanodevices selectively bind to a certain lipid phase with distinctive rigidities. Using the strand displacement method, these functionalized DNA origami nanostructures go through dimerization/monomerization steps, thereby ...
Rayehe Mamaghaniyeh, Henri G. Franquelim
wiley   +1 more source

Thematic review series: Lipid Posttranslational Modifications. Geranylgeranylation of Rab GTPases

Journal of Lipid Research, 2006
Rab GTPases require special machinery for protein prenylation, which include Rab escort protein (REP) and Rab geranylgeranyl transferase (RGGT). The current model of Rab geranylgeranylation proposes that REP binds Rab and presents it to RGGT.
Ka Fai Leung, Rudi Baron, Miguel C. Seabra   +2 more
doaj   +1 more source

Protein Prenylation Constitutes an Endogenous Brake on Axonal Growth

Cell Reports, 2016
Suboptimal axonal regeneration contributes to the consequences of nervous system trauma and neurodegenerative disease, but the intrinsic mechanisms that regulate axon growth remain unclear.
Hai Li, Takaaki Kuwajima, Derek Oakley, Elena Nikulina, Jianwei Hou, Wan Seok Yang, Emily Rhodes Lowry, Nuno Jorge Lamas, Mackenzie Weygandt Amoroso, Gist F. Croft, Raghavendra Hosur, Hynek Wichterle, Said Sebti, Marie T. Filbin, Brent Stockwell, Christopher E. Henderson   +15 more
doaj   +1 more source

A novel bisphosphonate inhibitor of squalene synthase combined with a statin or a nitrogenous bisphosphonate in vitro[S]

Journal of Lipid Research, 2011
Statins and nitrogenous bisphosphonates (NBP) inhibit 3-hydroxy-3-methylglutaryl-coenzyme-A reductase (HMGCR) and farnesyl diphosphate synthase (FDPS), respectively, leading to depletion of farnesyl diphosphate (FPP) and disruption of protein prenylation.
Brian M. Wasko, Jacqueline P. Smits, Larry W. Shull, David F. Wiemer, Raymond J. Hohl   +4 more
doaj   +1 more source

Inhibition of Prenylation Promotes Caspase 3 Activation, Lamin B Degradation and Loss in Metabolic Cell Viability in Pancreatic β-Cells

Cellular Physiology and Biochemistry, 2017
Background/Aims: Lamins are intermediate filament proteins that constitute the main components of the lamina underlying the inner-nuclear membrane and serve to organize chromatin.
Khadija G. Syeda, Anjan Kowluru
doaj   +1 more source

Oocytes orchestrate protein prenylation for mitochondrial function through selective inactivation of cholesterol biosynthesis in murine species. [PDF]

J Biol Chem, 2023
Sang Y, Yang Q, Guo Y, Liu X, Shen D, Jiang C, Wang X, Li K, Wang H, Yang C, Ding L, Sun H, Guo X, Li C.   +13 more
europepmc   +1 more source

Geranylgeranyl Pyrophosphate Promotes Hepatic Lipid Accumulation by Prenylation of Perilipin4Summary

Cellular and Molecular Gastroenterology and Hepatology
Background & Aims: Metabolically unhealthy obesity (MUO) is characterized by hepatic steatosis and type 2 diabetes (T2D), distinct from metabolically healthy obesity (MHO). This study aimed to identify the key regulator responsible for MUO.
Yue Zhao, Hong-Yu Nie, Shan Jiang, Meng-Fei Zhao, Peng Sun, Jing-Zi Zhang, Xiao-Chen Wang, Yi-Ping Tang, Ming-jie Zou, Xian-Wen Yuan, Xi-Tai Sun, Xiao-Dong Shan, Jian He, Jiang-Huai Liu, Yan Bi, Lei Fang, Xiao Han, Chao-Jun Li   +17 more
doaj   +1 more source

Mevalonate metabolism governs cancer immune surveillance

OncoImmunology, 2017
The metabolic reprogramming that drives immunity engages the mevalonate pathway for cholesterol biosynthesis and protein prenylation. The importance of tight regulation of this metabolic route is reflected by the fact that too low activity impairs ...
Georg Gruenbacher, Martin Thurnher
doaj   +1 more source

Chemical combinations elucidate pathway interactions and regulation relevant to Hepatitis C replication

Molecular Systems Biology, 2010
The search for effective Hepatitis C antiviral therapies has recently focused on host sterol metabolism and protein prenylation pathways that indirectly affect viral replication. However, inhibition of the sterol pathway with statin drugs has not yielded
Christopher M Owens, Christina Mawhinney, Jill M Grenier, Ralf Altmeyer, Margaret S Lee, Alexis A Borisy, Joseph Lehár, Lisa M Johansen   +7 more
doaj   +1 more source