Analysis of pmpD expression and PmpD post-translational processing during the life cycle of Chlamydia trachomatis serovars A, D, and L2. [PDF]
PLoS ONE, 2009 BACKGROUND: The polymorphic membrane protein D (PmpD) in Chlamydia is structurally similar to autotransporter proteins described in other bacteria and may be involved in cellular and humoral protective immunity against Chlamydia.
Andrey O Kiselev +2 more
doaj +9 more sources
Experimental annotation of post-translational features and translated coding regions in the pathogen
BMC Genomics, 2011 Background Complete and accurate genome annotation is crucial for comprehensive and systematic studies of biological systems. However, determining protein-coding genes for most new genomes is almost completely performed by inference using computational ...
Smith Richard D +15 more
doaj +4 more sources
Cell specific post-translational processing of pikachurin, a protein involved in retinal synaptogenesis. [PDF]
PLoS ONE, 2012 Pikachurin is a recently identified, highly conserved, extracellular matrix-like protein. Murine pikachurin has 1,017 amino acids (~110 kDa), can bind to α-dystroglycan, and has been found to localize mainly in the synaptic cleft of photoreceptor ribbon ...
Jianzhong Han, Ellen Townes-Anderson
doaj +5 more sources
SUMOylation by Pias1 regulates the activity of the Hedgehog dependent Gli transcription factors. [PDF]
PLoS ONE, 2010 BACKGROUND:Hedgehog (Hh) signaling, a vital signaling pathway for the development and homeostasis of vertebrate tissues, is mediated by members of the Gli family of zinc finger transcription factors. Hh signaling increases the transcriptional activity of
Barny Cox, James Briscoe, Fausto Ulloa
doaj +6 more sources
Cellular electron microscopy imaging reveals the localization of the Hfq protein close to the bacterial membrane. [PDF]
PLoS ONE, 2009 BackgroundHfq is a bacterial protein involved in several aspects of nucleic acid transactions, but one of its best-characterized functions is to affect the post-transcriptional regulation of mRNA by virtue of its interactions with stress-related small ...
Elia Diestra +3 more
doaj +7 more sources
Post-translational processing targets functionally diverse proteins in Mycoplasma hyopneumoniae [PDF]
Open Biology, 2016 Mycoplasma hyopneumoniae is a genome-reduced, cell wall-less, bacterial pathogen with a predicted coding capacity of less than 700 proteins and is one of the smallest self-replicating pathogens. The cell surface of M.
Jessica L. Tacchi +10 more
doaj +5 more sources
Efficient trapping of HIV-1 envelope protein by hetero-oligomerization with an N-helix chimera [PDF]
Retrovirology, 2005 Background The N-heptad repeat region of the HIV-1 Transmembrane Envelope protein is a trimerization domain that forms part of a "six helix bundle" crucial to Envelope-mediated membrane fusion.
Silver Jonathan, Ou Wu
doaj +4 more sources
The Role of Pumilio RNA Binding Protein in Plants
Biomolecules, 2021 Eukaryotic organisms have a posttranscriptional/translational regulation system for the control of translational efficiency. RNA binding proteins (RBPs) have been known to control target genes.
Sung Un Huh
doaj +1 more source
Frontiers in Physiology, 2021 The accumulation of unfolded/misfolded proteins in the endoplasmic reticulum (ER) causes ER stress and induces the unfolded protein response (UPR) and other mechanisms to restore ER homeostasis, including translational shutdown, increased targeting of ...
Emily M. Nakada +7 more
doaj +1 more source
Journal of Experimental & Clinical Cancer Research, 2021 Background Murine xenografts of pediatric leukemia accurately recapitulate genomic aberrations. How this translates to the functional capacity of cells remains unclear. Here, we studied global protein abundance, phosphorylation, and protein maturation by
Anuli C. Uzozie +11 more
doaj +1 more source